Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India

Sowjanya, A. Pavani; Jain, Meenkashi; Poli, Usha Rani; Padma, S; Das, Manik Chandra; Shah, Keerti V.; Rao, BN; Devi, Radha Rama; Gravitt, Patti E.; Ramakrishna, Gayatri

doi:10.1186/1471-2334-5-116

Cited by 128 publications

(109 citation statements)

References 23 publications

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“…The results of this study are in agreement with those of Sowjanya et al [7] who have reported that the most prevalent HPV types found in invasive cervical cancer cases in Andhra Pradesh were HPV 16 followed by HPV 18. The evaluation of the distribution and prevalence of major HPV types has special importance for the development of HPV vaccines.…”

Section: Discussionsupporting

confidence: 83%

“…From this study, it is evident that there is a strong association of HPV positivity with higher grades of CIN (Table 5). Similar results have been obtained by Sowjanya et al [7] in their study in Andhra Pradesh. High-risk HPV prevalence was found to be 87.8 % in their sample of invasive squamous cell carcinomas.…”

Section: Discussionsupporting

confidence: 81%

“…The evaluation of the distribution and prevalence of major HPV types has special importance for the development of HPV vaccines. To maximize the cost effectiveness of the HPV vaccination programs in India, it is important to understand the distribution of the major HPV types in various geographical regions [7]. More comprehensive genotyping of cervical cancer tissues from various parts of India will be needed to justify a single national vaccine strategy for the Indian subcontinent.…”

Section: Discussionmentioning

confidence: 99%

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Detection of HPV by PCR—A Novel Step in the Prevention of Cancer Cervix

Matah

Sareen

2012

J Obstet Gynecol India

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Objectives (1) To compare the efficacy of Pap smear and HPV PCR for detection of CIN; and (2) To study the distribution of HPV genotypes. Methods One hundred women presenting at the female Outpatient Department with unhealthy cervices were subjected to a detailed history, clinical examination, Pap smear, HPV DNA PCR test, and colposcopic-directed biopsy (where indicated). Results This study has shown that there is a strong association of HPV infection with higher grades of CIN (100 % in patients with CIN 2, CIN 3, and CIS). The detection of CIN by HPV PCR was more accurate than by Pap smear. The most prevalent HPV genotype found in our study was HPV 16. Conclusion The advent of HPV testing has opened the doors for more accurate cervical cancer surveillance strategies than Pap smear. Early detection and treatment of CIN will considerably reduce the incidence of cervical cancer.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Detection of HPV by PCR—A Novel Step in the Prevention of Cancer Cervix

Matah

Sareen

2012

J Obstet Gynecol India

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“…These results again show insufficient knowledge of HPV infection being the cause of cervical cancer in health professionals, even though 98% of cervical cancer are due to HPV infection, as reported in various studies in India. 17,18 In our study majority of nurses were not aware of any of the presenting symptoms. Only 25 (14.7%) of the nurses knew cancer cervix is associated with excessive vaginal bleeding, 72 (42.4%) knew about malodorous discharge, 39 (22.9%) knew about post coital bleeding as presenting symptom.…”

Section: Discussionmentioning

confidence: 99%

Knowledge and awareness of cervical cancer and its prevention among nursing staff of a tertiary care teaching institute in South India

Dhodapkar

Chauhan

Thampy

2014

Int J Reprod Contracept Obstet Gynecol

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“…Approximately 70% of cervical cancers in India are caused by HPV types 16 and 18, which are targeted by the vaccine [7,8]. However, there has been little empirical research on the feasibility, acceptability, and effectiveness of HPV vaccination in India.…”

Section: Primary Prevention Through Hpv Vaccinationmentioning

confidence: 99%

Advancing Cervical Cancer Prevention in India: Implementation Science Priorities

et al. 2013

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Cervical cancer is the leading cause of cancer mortality in India, accounting for 17% of all cancer deaths among women aged 30 to 69 years. At current incidence rates, the annual burden of new cases in India is projected to increase to 225,000 by 2025, but there are few large-scale, organized cervical cancer prevention programs in the country. We conducted a review of the cervical cancer prevention research literature and programmatic experiences in India to summarize the current state of knowledge and practices and recommend research priorities to address the gap in services. We found that research and programs in India have demonstrated the feasibility and acceptability of cervical cancer prevention efforts and that screening strategies requiring minimal additional human resources and laboratory infrastructure can reduce morbidity and mortality. However, additional evidence generated through implementation science research is needed to ensure that cervical cancer prevention efforts have the desired impact and are cost-effective. Specifically, implementation science research is needed to understand individual-and community-level barriers to screening and diagnostic and treatment services; to improve health care worker performance; to strengthen links among screening, diagnosis, and treatment; and to determine optimal program design, outcomes, and costs. With a quarter of the global burden of cervical cancer in India, there is no better time than now to translate research findings to practice. Implementation science can help ensure that investments in cervical cancer prevention and control result in the greatest impact. The Oncologist 2013;18:1285-1297 Implications for Practice: Considerable research has been conducted on the prevention of cervical cancer in India. The majority of studies have focused on the feasibility, acceptability, and impact of secondary prevention of cancer through screening, early detection, and treatment. Despite this evidence, there have been few government-led public health programs to prevent and control cervical cancer. The primary goals of this review are to summarize the lessons learned from cervical cancer prevention research and pilot programs in India and to identify research priorities to facilitate the translation of existing knowledge into policies and programs that advance cervical cancer prevention.

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Prevalence and distribution of high-risk human papilloma virus (HPV) types in invasive squamous cell carcinoma of the cervix and in normal women in Andhra Pradesh, India

Cited by 128 publications

References 23 publications

Detection of HPV by PCR—A Novel Step in the Prevention of Cancer Cervix

Detection of HPV by PCR—A Novel Step in the Prevention of Cancer Cervix

Knowledge and awareness of cervical cancer and its prevention among nursing staff of a tertiary care teaching institute in South India

Advancing Cervical Cancer Prevention in India: Implementation Science Priorities

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