Prevalence and distribution of HPV genotypes among HIV-infected women in Zambia

Sahasrabuddhe, Vikrant V.; Mwanahamuntu, Mulindi; Vermund, Sten H.; Huh, Warner K.; Lyon, Martha D.; Stringer, Jeffrey S. A.; Parham, Groesbeck P.

doi:10.1038/sj.bjc.6603737

Cited by 134 publications

(134 citation statements)

References 20 publications

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“…It is also of the highest HPV prevalence reported in any study in western Africa (Xi et al, 2003;Wall et al, 2005;Lack et al, 2005) or other parts of sub-Saharan Africa (de Sanjosé et al, 2007;Castellsagué et al, 2008), with the exception of those that included only, or a majority of, HIV-positive women (Sahasrabuddhe et al, 2007). Differences in age and sensitivity of PCR testing methods, however, limit the direct comparability with studies other than the IARC HPV Prevalence Surveys.…”

Section: Discussionmentioning

confidence: 97%

HPV infection in women with and without cervical cancer in Conakry, Guinea

et al. 2009

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BACKGROUND: Cervical cancer incidence in western Africa is among the highest in the world. METHODS: To investigate human papillomavirus (HPV) infection in Guinea, we obtained cervical specimens from 831 women aged 18 -64 years from the general population of the capital Conakry and from 77 locally diagnosed invasive cervical cancers (ICC). Human papillomavirus was detected using a GP5 þ /6 þ PCR-based assay. RESULTS: Among the general population, the prevalence of cervical abnormalities was 2.6% by visual inspection and 9.5% by liquidbased cytology. Fourteen of 15 high-grade squamous intraepithelial lesions were visual inspection-negative. Human papillomavirus prevalence was 50.8% (32.1% for high-risk types) and relatively constant across all age groups. Being single or reporting X3 sexual partners was significantly associated with HPV positivity. HPV16 was the most common type, both among the general population (7.3%) and, notably in ICC (48.6%). HPV45 (18.6%) and HPV18 (14.3%), the next most common types in ICC, were also more common in ICC than in HPV-positive women with normal cytology from the general population. CONCLUSION: The heavy burden of HPV infection and severe cervical lesions in Guinean women calls for new effective interventions. Sixty-three per cent of cervical cancers are theoretically preventable by HPV16/18 vaccines in Guinea; perhaps more if some cross-protection exists with HPV45.

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Section: Discussionmentioning

confidence: 97%

HPV infection in women with and without cervical cancer in Conakry, Guinea

et al. 2009

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“…25 Similar studies also carried out in other parts of Africa showed a prevalence of as high as 97.2%. 26 These variations in figures may be attributable to the exhaustive nature of the HPV detection strategy used in the various studies especially those carried out in Asia and America.…”

Section: Discussionmentioning

confidence: 99%

Oncogenic human papilloma virus infection among women attending the cytology clinic of a tertiary hospital in Lagos, South-West Nigeria

2014

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“…10 The high HIV prevalence could explain the observed HPV genotype distribution, since HIV-infected women are reported to acquire a broader spectrum of HPV genotypes other than HPV 16 or 18. [11][12][13] Most previous studies in South Africa were conducted in low HIV prevalence areas. This finding is epidemiologically important because the existing vaccine may not be as efficacious in this region of South Africa.…”

Section: Discussionmentioning

confidence: 99%

HPV genotypes in women with squamous intraepithelial lesions and normal cervixes participating in a community-based microbicide study in Pretoria, South Africa

Said

Ahmed

Burnett

et al. 2009

Journal of Clinical Virology

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a b s t r a c tBackground: Little is known regarding the human papillomaviruses (HPV) genotypes prevalent in women in South Africa, a country with a high incidence of cervical cancer.Objective: To determine the prevalence and HPV genotypes in women with squamous abnormalities and normal cervixes participating in a community-based microbicide study. Study design: A total of 159 cervical specimens, including 56 specimens from women with abnormal cytology (cases) and 103 randomly selected specimens from women with normal cytology (controls), were collected. HPV was detected by consensus PCR primers and HPV genotypes were determined by Roche Linear Array ® HPV genotyping assay. Results: HPV genotypes were found in 91% of cases and 40% of controls (p < 0.005). High-risk HPV was detected in all high-grade squamous intraepithelial lesions (HSILs), 69% of low-grade squamous intraepithelial lesions (LSILs), 57% of atypical squamous cells of undetermined significance (ASCUS), and 86% of ASCUS in which HSIL could not be excluded (ASCUS-H), and 73% of HPV positive controls. HPV-35 was the predominant genotype in HSILs; HPV-18 in ASCUS; HPV-58 in ASCUS-H and HPV-16 in LSILs and controls. Conclusion: High-risk HPV prevalence was high in both cases and controls. HPV genotype distribution in HSILs was different from that reported worldwide and from other studies in South Africa.

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Prevalence and distribution of HPV genotypes among HIV-infected women in Zambia

Cited by 134 publications

References 20 publications

HPV infection in women with and without cervical cancer in Conakry, Guinea

HPV infection in women with and without cervical cancer in Conakry, Guinea

Oncogenic human papilloma virus infection among women attending the cytology clinic of a tertiary hospital in Lagos, South-West Nigeria

HPV genotypes in women with squamous intraepithelial lesions and normal cervixes participating in a community-based microbicide study in Pretoria, South Africa

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