Prevalence and distribution of human papillomavirus genotypes in Chinese women between 1991 and 2016: A systematic review

Zhou, Hong-Lu; Zhang, Wei; Zhang, Can-Jing; Wang, Songmei; Duan, Yachen; Wang, Jinxia; Yang, Huan; Wang, Xuanyi

doi:10.1016/j.jinf.2018.02.008

Cited by 46 publications

(49 citation statements)

References 21 publications

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“…China has actively promoted the screening and prevention of cervical cancer in recent years, but the incidence and mortality of cervical cancer have remained high, and the age distribution becomes younger. Currently, the vaccines for cervical cancer are mainly targeted at tetravalent vaccine (HPV 16, 18, 6, and 11) and bivalent vaccine (HPV 16 and 18), based on the data from HPV epidemiological survey in Europe or the United States . It needs to be considered whether the vaccines are suitable for Chinese population.…”

Section: Introductionmentioning

confidence: 99%

“…It is very important to understand and grasp the distribution of HPV in Chinese general population, which provides scientific basis for prevention and treatment of cervical cancer. In 2018, Zhou HL and Xu HH et al respectively published a systematic review on prevalence and distribution of HPV in patients, which has invasive carcinoma of cervix (ICC), high‐grade squamous intraepithelial lesion (HSIL), or low‐grade squamous intraepithelial lesion (LSIL) . These studies mainly studied the prevalence and distribution of HPV in patients, but did not study on general population; the results might be influenced by selection bias, which cannot indeed reflect the real situation of HPV infection in general population.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, the vaccines for cervical cancer are mainly targeted at tetravalent vaccine (HPV 16, 18, 6, and 11) and bivalent vaccine (HPV 16 and 18), based on the data from HPV epidemiological survey in Europe or the United States. 8 It needs to be considered whether the vaccines are suitable for Chinese population. It is very important to understand and grasp the distribution of HPV in Chinese general population, which provides scientific basis for prevention and treatment of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

“…In 2018, Zhou HL and Xu HH et al respectively published a systematic review on prevalence and distribution of HPV in patients, which has invasive carcinoma of cervix (ICC), high-grade squamous intraepithelial lesion (HSIL), or low-grade squamous intraepithelial lesion (LSIL). 8,9 These studies mainly studied the prevalence and distribution of HPV in patients, but did not study on general population; the results might be influenced by selection bias, which cannot indeed reflect the real situation of HPV infection in general population. Therefore, we perform this study to integrate the findings of 68 population-based studies.…”

Section: Introductionmentioning

confidence: 99%

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The prevalence, trends, and geographical distribution of human papillomavirus infection in China: The pooled analysis of 1.7 million women

et al. 2019

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Human papillomavirus (HPV) infection which continues to be the most common sexually transmitted disease, has been identified as a major risk factor for cervical cancer. Therefore, it is very important to understand and grasp the distribution of HPV in Chinese population, and make the foundation for the development of cervical cancer vaccine in China. An extensive search strategy was conducted in multiple literature databases. All retrieved studies were screened by October 31, 2018. The prevalence of HPV infection was analyzed using random effects model. A total of 68 studies satisfied the inclusion criteria for our study. The national overall prevalence of HPV infection was 15.54% (95% CI: 13.83%‐17.24%). we also performed subgroup analysis by age, geographic location, level of economic development, HPV assay method, and type of HPV infection. The top 5 common HPV types detected in general population, were HPV 16 (3.52%, 95% CI: 3.18%‐3.86%), 52 (2.20%, 95% CI: 1.93%‐2.46%), 58 (2.10%, 95% CI: 1.88%‐2.32%), 18 (1.20%, 95% CI: 1.05%‐1.35%), and 33 (1.02%, 95% CI: 0.89%‐1.14%). Except for the higher prevalence of HPV infection in 2009 and 2010, the prevalence of HPV infection in other years changed little, ranged from 13.2% to 17.4%. HPV type in Chinese women was quite distinctive. HPV infection played a critical role in the occurrence of cervical cancer, understanding the distribution of HPV type and performing the HPV type testing had important clinical value for colposcopy referral and increasing the detection rate. Therefore, our findings could provide evidence for cervical cancer screening and vaccine, in order to reduce the burden of cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The prevalence, trends, and geographical distribution of human papillomavirus infection in China: The pooled analysis of 1.7 million women

et al. 2019

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“…There are over 45 million Chinese women are infected by hrHPVs annually. Up to 19 million of them are at the stage of low‐grade cervical lesions, 17 million at the stage of high‐grade lesions and 99 thousand at the stage of cervical cancer . Another investigation showed that more than 20% female patients are hrHPV‐positive in hospital examination and most of them belong to persistent infections.…”

Section: Introductionmentioning

confidence: 99%

REBACIN® as a noninvasive clinical intervention for high‐risk human papillomavirus persistent infection

Yang

Duan

et al. 2019

Intl Journal of Cancer

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The development of highly sensitive HPV‐genotyping tests has opened the possibility of treating HPV‐infected women before high‐grade lesions appear. The lack of efficient intervention for persistent high‐risk HPV infection necessitates the need for development of novel therapeutic strategy. Here we demonstrate that REBACIN®, a proprietary antiviral biologics, has shown potent efficacy in the clearance of persistent HPV infections. Two independent parallel clinical studies were investigated, which a total of 199 patients were enrolled and randomly divided into a REBACIN®‐test group and a control group without treatment. The viral clearance rates for the REBACIN® groups were 61.5% (24/39) and 62.5% (35/56), respectively, for the two independent parallel studies. In contrast, the nontreatment groups showed self‐clearance rates at 20.0% (8/40) and 12.5% (8/64). We further found that REBACIN® was able to significantly repress the expression of HPV E6 and E7 oncogenes in TC‐1 and Hela cells. The two viral genes are well known for the development of high‐grade premalignancy lesion and cervical cancer. In a mouse model, REBACIN® was indicated to notably suppress E6/E7‐induced tumor growth, suggesting E6 and E7 oncogenes as a potential target of REBACIN®. Taken together, our studies shed light into the development of a novel noninvasive therapeutic intervention for clearance of persistent HPV infection with significant efficacy.

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Advances in early diagnosis of cervical cancer based on biosensors

Ghaleh

Shahriary

Izadi

et al. 2022

Biotech & Bioengineering

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Human papillomavirus (HPV) is a causative agent of cervical cancer among women worldwide. Serological and molecular tests are commonly used to detect and identify HPV, but all the detection methods for HPV have some limitations. Nowadays, considerable advancements in nanosensors have enabled monitoring of hybridization procedures dynamically for HPV detection. Biosensors, as effective, quick, economical, and highly sensitive tools, can be used in the diagnosis of HPV as an alternative technique instead of other detection methods. Biosensor detection methods of HPV in use from 2000 to 2021 were investigated using several databases such as Google Scholar, Scopus, PubMed, and the Scientific Information Database. Furthermore, a manual search of the references of the retrieved articles was performed. On analyzing the most recently developed biosensors for HPV identification, we observed that three biosensor systems, electrochemical, optical, and piezoelectric systems, are the main transducers used in the development of HPV biosensors. The aim of this review is to examine recent research on biosensors for the detection of HPV and perform a comparison with other diagnostic methods.Considering the importance of rapid HPV detection in the control of infection and development of public health measures, improvement of biosensors as an economical and quick method can be very useful in the diagnosis of HPV.

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Prevalence and distribution of human papillomavirus genotypes in Chinese women between 1991 and 2016: A systematic review

Cited by 46 publications

References 21 publications

The prevalence, trends, and geographical distribution of human papillomavirus infection in China: The pooled analysis of 1.7 million women

The prevalence, trends, and geographical distribution of human papillomavirus infection in China: The pooled analysis of 1.7 million women

REBACIN® as a noninvasive clinical intervention for high‐risk human papillomavirus persistent infection

Advances in early diagnosis of cervical cancer based on biosensors

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