Prevalence and distribution of human papillomavirus genotypes among women with high‐grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China

Liao, Linhong; Cheng, Hongye; Zeng, Fansheng; Zhou, Weijie; Ding, Yanqing

doi:10.1002/jcla.22708

Cited by 12 publications

(12 citation statements)

References 27 publications

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“…In general, there are substantial differences between different countries and geographical areas in genotype distribution of HPV infections 12. As in our study, several studies have shown that types 52 and 58 are the most commonly seen high-risk HPV types in patients without any intra-epithelial lesions 3–5 10 13.…”

Section: Discussionsupporting

confidence: 62%

Correlation of Swede score colposcopy scoring system and histopathological results in patients with high-risk HPV infection other than HPV16 and 18

Alan

Günyeli

Gültekin

et al. 2019

Int J Gynecol Cancer

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ObjectiveTriage with HPV genotyping has some caveats and debates for HPV positive cases other than 16 and 18. The Swede score colposcopic scoring system has not previously been evaluated in this group of patients.ObjectiveTo use the Swede score colposcopic scoring system to compare scores and final histopathological results in women who have undergone colposcopy owing to infection with high risk-HPVs other than HPV16 and 18 and to establish new cut-off values to predict pre-malignant lesions in this group of patients.MethodsThis study was conducted in 613 women undergoing colposcopic evaluation because of abnormal cervical cytology together with high-risk HPV infection. All patients referred were evaluated by an expert colposcopist, given a Swede score (using the Swede score colposcopic scoring system) by using five variables (acetowhiteness, margins plus surface, vessel pattern, lesion size, and iodine staining), and had at least one biopsy procedure (either colposcopically directed or by a loop electrical excision procedure). Sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio values, and receiver operating characteristic curves for each clinico-pathological variable to detect low-grade and high-grade squamous intra-epithelial lesions, and any squamous cell abnormality (low-grade + high-grade squamous intra-epithelial lesions) were evaluated individually.ResultsFinal histopathological results of the patients were normal in 53.2% of cases, low-grade lesions in 32.5% of cases, and high-grade lesions in 14.4% of cases. Swede score was ≥8 (median 7.97) for high-grade lesions and ≥5 (median 5.06) for low-grade lesions. The area under the curve values (95% CI) of Swede scores for low-grade and high-grade squamous intra-epithelial lesions, and low-grade + high grade lesions were 0.92, 0.98, and 0.96, respectively. A Swede score cut-off value ≥6 had a sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratios of 92%, 98%, 93%, 98%, and 50 (22.6 to 110.8), respectively, for high-grade lesions at the final pathology (P<0.001). One high-risk HPV type (except 16 and 18) was no better than another for calculating the median Swede score during colposcopy (P=0.43).ConclusionsThe Swede score colposcopic scoring system appears to be a useful tool for evaluating atypical cervical cytology in women with high-risk HPV infection other than HPV types 16 and 18.

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Section: Discussionsupporting

confidence: 62%

Correlation of Swede score colposcopy scoring system and histopathological results in patients with high-risk HPV infection other than HPV16 and 18

Alan

Günyeli

Gültekin

et al. 2019

Int J Gynecol Cancer

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“…The most common types of HPV detected in women with one or more HPV infections were HPV 16 (consistently detected in all of our patients), 18 (83%), 258 45 (33%), 33 (31%), 59 (28%), 35 (12%), 31 (11%), 58 (8%), 39 and 73 (4%), 44, 54 and 68 (3%) and the rest less than 1%. The high prevalence of HPV16 and HPV18 reported in our study was expected, as these types are the two most common types of HPV worldwide [23][24][25][26]. Several studies [27][28][29] have shown that genotypes 16 and 18 are responsible for 70.7% of cervical cancers, which explains why they were chosen as target for HPV vaccines.…”

Section: Year Of Diagnosis Place Of Residencesupporting

confidence: 62%

Human papilloma virus genotypes associated with cervical cancer in Senegal

Niane¹,

Tidiane²,

Diop³

et al. 2021

Biomed Res Rev

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BackgroundCervical cancer is the fourth commonest cancer affecting female population in the world, and the seventh most common cancer in the general population worldwide [1]. The disease is also the fourth leading cause of cancer death among women with 311,000 associated deaths in 2018. The highest regional incidence and mortality rates are seen in Africa, especially in Eastern (Malawi, with the highest mortality rate; and Zimbabwe) and Western Africa (Guinea, Burkina Faso, and Mali). Globally, it was previously admitted that low-and middle-income countries account for almost 90% of the burden of cervical cancer [2] due to insufficient awareness, lack of effective screening programs, and late clinical presentation. In addition, reports of trends in cervical cancer mortality in these countries have been limited by poor data quality and inaccurate estimates of population [3]. Additionally, in most of these countries, especially in sub-Saharan Africa, there is no cancer registry. Human papillomavirus (HPV) is a causative agent of cervical cancer that has been detected in 99.7% of cervical squamous cell carcinoma and in 94-100% of cervical adenocarcinoma [4]. HPV is transmitted through sexual intercourse or skin-to-skin genital contact [5], and persistent infection with high-risk HPV (HR-HPV) is the major cause of cervical intraepithelial neoplasia and invasive cervical cancer [6][7][8]. In general, most infections resolve on their own, as the immune response controls infection and prevents progression to precancerous lesions [9]. Papillomaviruses are circular, nonenveloped double-stranded DNA viruses with a genome length of 8 kb. More than 200 HPV genotypes have been reported and grouped into cutaneous and mucosal types according to their site of infection, and then subdivided into high risk (HR) and low risk (LR) types, depending on their association with a particular infection. Malignant disease (IARC,

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“…According to the previously reported data, over 70% of women have had an HPV infection at least once in their lifetime, with about 10% having a lifelong persistent infection (Liao et al, 2018). Persistent HPV infection can cause abnormal proliferation of cells, and the accumulations of genetic damage leading to cancer of the cervix, vulva, vagina, anus, penis, and/or oropharynx (Crosbie et al, 2013;Hong et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and type distribution of human papillomavirus in a Chinese urban population between 2014 and 2018: a retrospective study

Cao

et al. 2020

PeerJ

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Background Human papilloma virus (HPV) infection is one of the most common sexually transmitted infections among women worldwide. The current study’s main objective is to report the prevalence and distribution of HPV types in an urban population in Beijing, China. Methods All the eligible female participants aged ≥18 years were recruited from the Aerospace Center Hospital in Beijing, China between 2014 and 2018. A total of 21 HPV types were detected by the polymerase chain reaction (PCR) reverse dot blot method and fluorescence quantitative PCR method. Results In total, 12 high risk HPV types and nine low risk HPV types were detected. The HPV-positive rates were 8.85% in 2014, 7.16% in 2015, 7.60% in 2016, 8.31% in 2017, and 7.72% in 2018, respectively, in an urban population in Beijing, China. Overall, no significant differences in the HPV-positive rates were found over the five years. The peak prevalence of HPV infection in all types was observed in age group of 20–24 in all types. HPV52 was the dominant HPV type across the five years . Among all 21 HPV types, HPV66, HPV26, and HPV59 were ranked the top three in coinfection occurrence. Conclusions Our findings are very helpful for HPV screening and vaccination. The associations between gynaecological diseases and the HPV types with high prevalence, particularly HPV52, warrant further investigation.

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Prevalence and distribution of human papillomavirus genotypes among women with high‐grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China

Cited by 12 publications

References 27 publications

Correlation of Swede score colposcopy scoring system and histopathological results in patients with high-risk HPV infection other than HPV16 and 18

Correlation of Swede score colposcopy scoring system and histopathological results in patients with high-risk HPV infection other than HPV16 and 18

Human papilloma virus genotypes associated with cervical cancer in Senegal

Prevalence and type distribution of human papillomavirus in a Chinese urban population between 2014 and 2018: a retrospective study

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