Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients

Lee, Yonghyun; Min, Pok-Kee; Lee, Seonggu; Kim, Shin‐Woo

doi:10.3346/jkms.2020.35.e174

Cited by 473 publications

(613 citation statements)

References 9 publications

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“…This result agrees partially with the meta-analysis that summarized the results of 43 studies, and the most common symptoms were fever (83%), cough (60%) and fatigue (38%) (17). A high prevalence of smell and taste loss occurred in the Syrian population, which was similar to other cross-sectional studies (18,19).…”

Section: Discussionsupporting

confidence: 89%

The Prevalence of COVID-19 Symptoms in Syria: A Cross-Sectional Study

Alhaffar

Abbas

Nassar

2020

Preprint

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Introduction: The corona virus disease 2019 is a disease caused by the newly discovered human infecting SARS-Co V-2 virus. The COVID-19 virus is highly transmittable, by August 14, 2020, more than 20 million people were confirmed to have COVID-19 worldwide, with more than 750,000 death. Syria was declared to have one of most vulnerable health systems in the world, with poor surveillance systems, unstable conditions, no standardized method for reporting infections, lack of sufficient public awareness, and a continued deterioration of humanitarian and socio-economic conditions across Syria.Objectives: to investigate the prevalence of COVID-19 symptoms among the Syrian population.Methods: this is a cross sectional study in Damascus – Syria, data were collected during August, 2020 using an online questionnaire that contained 3 section (demographic variables, awareness of COVID-19, symptoms of COVID-19) and analyzed using SPSS v.22.Results: 5212 people were included in the study, 59% females and 41% males, 9.6% had chronic medical conditions. 63.4% reported experiencing COVID-19 symptoms during the past 6 months, symptoms lasted 6.9 days on average, the most prevalent symptoms were as anosmia and dysgeusia (42.2%), headache (67.1%), fatigue (70%). Symptoms were significantly more prevalent in the past 14 days (P=0.000).Conclusion: Within the limits of this study, high prevalence of covid-19 symptoms was noticed in the Syrian population. Significant correlation was made between the severity and duration of the symptoms. Measures to slow down spread of COVID-19 need to be taken immediately.

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Section: Discussionsupporting

confidence: 89%

The Prevalence of COVID-19 Symptoms in Syria: A Cross-Sectional Study

Alhaffar

Abbas

Nassar

2020

Preprint

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“…There were symptoms noted only in one study (sneezing, tonsil swelling, cold, conjunctival injection/ congestion, ocular pain, rash, lymphadenopathy, anosmia and malaise) thus giving a poor statistical con dence on prevalence. Ageusia and hypogeusia (loss and reduced taste sensation) were not identi ed from the meta-analysis but were well reported from several regions including Europe 57 , Korea 58 addition to what so far described in our study 59 .…”

Section: Ranking Of Symptomssupporting

confidence: 52%

Symptomatology of Coronavirus Disease 2019 (COVID-19) - Lessons from a meta-analysis across 13 countries

Gamakaranage

Hettiarachchi

Ediriweera

et al. 2020

Preprint

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Background: COVID-19 pandemic has resulted in varying clinical manifestations and mortality rates. There is no consensus on the symptomatology that would guide researchers and clinicians. Objective: The objective was to identify symptoms and their frequencies of COVID-19 with a meta-analysis of studies from several countries. Data sources: A systematic review using PubMed and Google Scholar data sources and reference tracing were used to identify 7176 articles. Eligibility criteria: Suitable articles were selected manually with selection criteria and 14 original articles included in meta-analysis. Data abstraction and analysis: PRISMA guidelines, used for data abstraction and a table was generated by feeding it with numbers and proportions of each symptom described. A meta-analysis was carried out using random effect models on each symptom separately across the studies and their prevalence rates and 95% confident intervals were calculated.Results: Selected 14 studies, either cross-sectional or cohort studies are analyzed. There were 2,660 confirmed cases of COVID-19. The majority were from China (n=2,439, 91.7%) and remainder from the Netherlands, Italy, Korea and India and one article from Europe. There was a total of 32 symptoms identified from the meta-analysis and additional 7 symptoms were identified from reference searching. The most common symptoms were (prevalence >50%): fever (79.56%, 95% CI: 72.17-86.09%), malaise (63.3%, 95% CI: 53.1 – 73.0%), cough (56.7. %, 95% CI: 48.6 - 64.6 %) and cold (55.6%, 95% CI: 45.2 – 65.7%). Symptoms of intermediate incidence (5-49%) were; anosmia, sneezing, ocular pain, fatigue, sputum production, arthralgia, tachypnea, palpitation, headache, chest tightness, shortness of breath, chills, myalgia, sore throat, anorexia, weakness, diarrhea, rhinorrhea, dizziness, nausea, altered level of consciousness, vomiting and abdominal pain. Rare symptoms (<5%): tonsil swelling, haemoptysis, conjunctival injection, lymphadenopathy and rash. Conclusion and implications of key findings: We found (25/32, from meta-analysis) symptoms to be present in =>5% of cases which could be considered as “typical” symptoms of COVID-19. The list of symptoms we identified is different from those documents released by the WHO, CDC, NHS, Chinese CDC, Institute Pasteur and Mayo Clinic. The compiled list would be useful for future researchers to document a comprehensive picture of the illness.

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“…It is noteworthy that the detection of the cause of the loss of these senses is crucial in supporting the diagnosis of this disease. Lee et al(2020) in survey of 3191 patients in Korea showed anosmia or ageusia in 15% patients in the early stage of COVID-19 and in 16% patients with asymptomatic-to-mild disease severity (55). Also, a recent study reported almost one-fth of the patients presented the symptoms before the hospital admission (18).…”

Section: Discussionmentioning

confidence: 99%

Olfactory and gustatory dysfunction in 2019 novel coronavirus: An updated systematic review and meta-analysis

Esmaeili

Abdi

Shafiee

et al. 2020

Preprint

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BackgroundEvidence showed that partial or complete loss of smell and taste might be a possible primary symptom of the 2019 novel coronavirus (COVID-19). This study aimed to systematically review and pool all available evidence on the olfactory and gustatory dysfunction in COVID-19 patients. MethodsIn this systematic review, a comprehensive search was carried out systematically through e-databases including PubMed, EMBASE, Scopus, and Web of Science (WoS); that was limited to English-language studies published from 2019 up to 6th May 2020. Afterward, all studies reported the taste and smell dysfunction in the COVID-19 patients were included. The quality of the studies was assessed by the Mixed Methods Appraisal Tool (MMAT). The pooled prevalence of olfactory and gustatory dysfunction was estimated using the random effects meta-analysis method.ResultsAmong 28 eligible included studies in this systematic review, finally, 22 studies met the eligibility criteria and were included in the meta-analysis. According to the random effect meta-analysis, the global pooled prevalence (95% confidence interval) of any olfactory dysfunction, anosmia, and hyposmia was 55% (40%-70%), 40% (22%-57%), and 40% (20%-61%) respectively. The pooled estimated prevalence of any gustatory dysfunction, ageusia, and dysgeusia was 41% (23%-59%), 31% (3%-59%), and 34% (19%-48%) respectively. ConclusionOlfactory and gustatory dysfunction is prevalent among COVID-19 patients. Therefore, olfactory and gustatory dysfunction seems to be part of important symptoms and notify for the diagnosis of COVID-19, especially in the early phase of the infection.

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Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients

Cited by 473 publications

References 9 publications

The Prevalence of COVID-19 Symptoms in Syria: A Cross-Sectional Study

The Prevalence of COVID-19 Symptoms in Syria: A Cross-Sectional Study

Symptomatology of Coronavirus Disease 2019 (COVID-19) - Lessons from a meta-analysis across 13 countries

Olfactory and gustatory dysfunction in 2019 novel coronavirus: An updated systematic review and meta-analysis

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