Prevalence and epidemiology of micro- and macroalbuminuria in Ethiopian diabetic patients

Rahlenbeck, Sibylle I.; Gebre-Yohannes, A

doi:10.1016/s1056-8727(96)00122-5

Cited by 25 publications

(24 citation statements)

References 20 publications

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“…Kundu, et al [20] found out that urinary microalbumin, HbA 1c levels were significantly higher in the cases and microalbumin levels were linearly correlated to the duration of diabetes and HbA1c. The National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) stated that all diabetics with more than five years of the disease should be screened for microalbuminuria, although it appears after 10 years of the disease [21]. Rahlenbeck, et al in his study got results similar to this study [22].…”

Section: Microalbuminuriasupporting

confidence: 63%

Comparative Study of Significance of Serum Cystatin-C, Serum Creatinine and Microalbuminuria Estimation in Patients of Early Diabetic Nephropathy

Saurav¹

2015

J Diabetes Metab

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Section: Microalbuminuriasupporting

confidence: 63%

Comparative Study of Significance of Serum Cystatin-C, Serum Creatinine and Microalbuminuria Estimation in Patients of Early Diabetic Nephropathy

Saurav¹

2015

J Diabetes Metab

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“…More than 80% of patients had CKD and nearly 25% had an eGFR <60 ml/min/1.73 m 2 . This highlights the importance of implementing routine screening for CKD among adult diabetics in sub-Saharan Africa [10], a region where screening for nephropathy among adult diabetics is often not performed at all due to limited resources [4,7,10]. Early screening detection would allow, more aggressive measures to be taken (stricter glycemic control and use of Angiotensin II receptor blockade) to reverse microalbuminuria and/or prevent further adverse renal and cardiovascular outcomes [11,12].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic kidney disease in diabetic adult out-patients in Tanzania

et al. 2013

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BackgroundThe number of adults with diabetes mellitus is increasing worldwide, particularly in Asia and Africa. In sub-Saharan Africa, renal complications of diabetes may go unrecognized due to limited diagnostic resources. The prevalence of chronic kidney disease (CKD) among adult diabetics in sub-Saharan Africa has not been well described.MethodsThis study was conducted at the diabetes mellitus clinic of Bugando Medical Centre in Mwanza, Tanzania. A total 369 consecutive adult diabetic patients were enrolled and interviewed. Each patient provided a urine sample for microalbuminuria and proteinuria and a blood sample for serum creatinine level. Estimated glomerular filtration rate (eGFR) was calculated using the Cockroft-Gault equation. CKD was staged according to the Kidney Disease Improving Global Outcomes system.ResultsA total of 309 (83.7%) study participants had CKD; 295 (80.0%) had significant albuminuria and 91 (24.7%) had eGFR < 60 ml/min. None of these patients were aware of their renal disease, and only 5 (1.3%) had a diagnosis of diabetic nephropathy recorded in their file. Older age was significantly associated with CKD in this population [OR 1.03, p = 0.03, 95%CI (1.00-1.05)].ConclusionsChronic kidney disease is highly prevalent among adult diabetic outpatients attending our clinic in Tanzania, but is usually undiagnosed. Nearly ¼ of patients had an eGFR low enough to require dose adjustment of diabetic medications. More diagnostic resources are needed for CKD screening among adults in Tanzania in order to slow progression and prevent complications.

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“…Secondly, lack of screening is a contributing factor. In some centers, screening for diabetic nephropathy is not performed at all due to limited resources [24,25]. Other contributing factors include inadequate treatment of complications at an early stage, poor glycemic control, lack of awareness and poor knowledge on the complications of diabetes [23,26].…”

Section: Impact Of Type II Diabetes In Rural Kenyamentioning

confidence: 99%

How Serious is the Impact of Type II Diabetes in Rural Kenya?

Elbusaidy¹,

Dawood²,

Kasay³

et al. 2014

TODIAJ

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Over 50% of all adult hospital admissions and 55% of hospital deaths in Kenya are non-communicable, of which diabetes is among the leading. We aimed to describe the impact of type II diabetes at a rural community in Kenya. 200 healthy adult patients underwent random blood sucrose (RBS) testing after ethical approval by the Isiolo County Hospital. Diabetes was defined as RBS ≥11.1 mmol/l. A thorough history, physical examination and dipstick urinalysis for urine protein was done to identify risk factors and/or evidence of end organ damage. 32 patients (16%) had RBS ≥11.1 mmol/l. 12 patients (37.5%) never knew they were diabetic and those who knew 63% were not taking any medication. The most common risk factors were high fat diet (59.4%), sedentary lifestyle (46.8%) and family history of diabetes in first degree relative (37.5%). 43.7% of patients (n=14) had abdominal obesity while 21.9% (n=7) had various foot abnormalities. 8 patients (25%) had proteinuria of ≥ +1 on dipstick urinalysis. The 16% diabetes prevalence is among the highest recorded for a community living on ≤ 1 dollar/day. Further, evidence of end organ damage as depicted by massive proteinuria warrants urgent attention to this underprivileged group. It is hoped the results will form basis for future screening of diabetic nephropathy and other diabetes-related end organs involvement in this part of the world.

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Prevalence and epidemiology of micro- and macroalbuminuria in Ethiopian diabetic patients

Cited by 25 publications

References 20 publications

Comparative Study of Significance of Serum Cystatin-C, Serum Creatinine and Microalbuminuria Estimation in Patients of Early Diabetic Nephropathy

Comparative Study of Significance of Serum Cystatin-C, Serum Creatinine and Microalbuminuria Estimation in Patients of Early Diabetic Nephropathy

Prevalence of chronic kidney disease in diabetic adult out-patients in Tanzania

How Serious is the Impact of Type II Diabetes in Rural Kenya?

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