Prevalence and factors affecting the level of depression, anxiety, and stress in hospitalized patients with a chronic disease

Fattouh, Nour; Hallit, Souheil; Salameh, Pascale; Choueiry, Georges; Kazour, François; Hallit, Rabih

doi:10.1111/ppc.12369

Cited by 35 publications

(40 citation statements)

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“…Patients with endometriosis seem to display more somatization and sensitivity and more commonly experience fatigue or insomnia [39,52]. People with chronic diseases have a higher occurrence of psychological disorders such as depression, anxiety, and stress [57], and a similar pattern appears in patients with endometriosis. A recent meta-analysis provided strong evidence that women with endometriosis have higher psychological stress levels [58].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Our meta-analysis has several limitations. First, some research has noted that the mental health and quality of life of endometriosis patients are influenced by many factors, such as infertility, chronic pelvic pain, and dyspareunia; even the time of diagnosis and the patients' characteristics may play a role [54][55][56][57][58]. However, we did not include these factors in our subgroup analyses because many of the studies that we assessed did not pay attention to these factors.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Does Endometriosis Disturb Mental Health and Quality of Life? A Systematic Review and Meta-Analysis

Wang

Zhou

et al. 2021

Gynecol Obstet Invest

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Introduction: This study aimed to evaluate whether endometriosis could disturb the mental health and health-related quality of life (HRQoL) of patients and to provide a new prospective for further treatment of endometriosis. Methods: A comprehensive literature review was conducted among 4 international databases (PubMed, Embase, Web of Science, and Cochrane Library) and 2 of the largest Chinese databases (the China National Knowledge Infrastructure and Wangfang). The Newcastle-Ottawa Scale was used to assess the quality of the included articles. Six effect sizes were synthesized through a meta-analysis, and a subgroup analysis was performed to identify potential moderating factors, including types of control groups, methods of assessment, number of study groups, and origin of the study. Potential publication bias was examined using a funnel plot. Results: This meta-analysis pooled 44 articles from 4 continents and 13 countries and compared 6 types of main effect sizes (the odds ratio [OR] for depression, the OR for anxiety, the standardized mean difference [SMD] for depression, the SMD for anxiety, the SMD for the physical component summary [PCS] and the SMD for the mental component summary [MCS]) between endometriosis patients and controls. Except for the SMD for depression, all other effect sizes revealed statistically significant differences between the study group and the controls. The main effect size outcomes of the subgroup analysis were also similar. The type of control group (I2 = 35% in non-endometriosis control groups for the SMD of anxiety; I2 = 47% in non-endometriosis control groups for the MCS of the 36-Item Short Form Health Survey) and the continent of origin (I2 = 0% in studies from South America for the OR of depression; I2 = 47% in studies from Europe for the SMD of anxiety) may influence heterogeneity in this analysis. Additionally, depression and anxiety symptoms in patients seemed to be more apparent compared with healthy controls when the sample was smaller and when a questionnaire was used. The publication bias of the articles was acceptable. Conclusion: Endometriosis can disturb mental health (specifically depression and anxiety) and decrease both the mental and physical HRQoL of patients. There may be some moderating factors that we were unable to identify in the subgroup analysis, but more research is necessary to develop proper management and improve the prognosis of endometriosis patients.

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Section: Discussion/conclusionmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

Does Endometriosis Disturb Mental Health and Quality of Life? A Systematic Review and Meta-Analysis

Wang

Zhou

et al. 2021

Gynecol Obstet Invest

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“…Coronary artery disease (CAD) combined with anxiety and depression accelerates the process and aggravates the prognosis of cardiovascular disease [1,2]. The prevalence of anx-iety and depression is increasing among CAD patients [3][4][5], and it has been reported to be associated with raised cardiovascular mortality [6][7][8]. Emerging evidence suggests that CAD and anxiety/depression share a crucial pathophysiological characteristic-the disequilibrium of endothelial homeostasis [9,10].…”

Section: Introductionmentioning

confidence: 99%

Xinkeshu Improves Endothelial Function and Augments Reendothelialization Capacity in Coronary Artery Disease with Anxiety/Depression

Sun

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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The disruption of endothelial homeostasis is the hallmark of coronary artery disease (CAD) and psychological disorders such as anxiety/depression. Xinkeshu (XKS), a traditional Chinese patent medicine, plays an essential role in CAD and psychological condition; however, the mechanisms underlying the effects of XKS on the endothelial function and endogenous endothelium-repair capacity in CAD patients with anxiety/depression remain elusive. In this study, endothelial function and endothelial progenitor cell- (EPC-) mediated reendothelialization capacity were compared among age-matched healthy subjects, CAD patients with or without anxiety/depression. Besides, CAD patients with anxiety/depression received 1-month XKS treatment. Anxiety/depression symptoms were evaluated by Generalized Anxiety Disorder 7-item (GAD-7)/Patient Health Questionnaire-9 (PHQ-9) score, endothelial function was tested by flow mediated dilation (FMD) measurement, and EPC-mediated reendothelialization capacity was evaluated by a carotid artery injury model in nude mouse ( n = 6 ) with the injection of XKS-incubated EPCs from CAD patients with anxiety/depression. The results showed that FMD and EPC-mediated reendothelialization capacity of CAD patients with anxiety/depression were compromised compared to healthy subjects and CAD patients without anxiety/depression. After 1 month of XKS treatment, FMD increased from 4.29 ± 1.65 to 4.87 ± 1.58 % ( P < 0.05 ) in CAD patients with anxiety/depression, whereas it remained unchanged in the controls. Moreover, XKS decreased GAD-7 and PHQ-9 scores. Meanwhile, incubating XKS enhanced in vivo reendothelialization capacity and in vitro apoptosis of EPCs from CAD patients with anxiety/depression, which was associated with the upregulation of CXC-chemokine receptor 7 (CXCR7) and inhibition of phosphorylation of p38 signaling. CXCR7 knockdown abolished the beneficial effects of XKS, which was rescued by p38 inhibitor SB203580. Our data demonstrate for the first time that XKS improves endothelial function and enhances EPC-mediated reendothelialization through CXCR7/p38/cleaved casepase-3 signaling and provides novel insight into the detailed mechanism of XKS in maintaining endothelial homeostasis in CAD patients with anxiety/depression.

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“…Another reason for combined interest in these conditions is that a variety health conditions may in uence mental health in the elderly population, potentially generating more than one illness. For example, an elderly person who suffers one or more chronic disease has a greater chance of developing lateonset depression and/or anxiety [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

A Group-based Dual Trajectory of Depression and Anxiety in Older Adults: An 8-year Follow-up of Population-based Study

Cheng¹,

Thorpe²,

Kabir³

et al. 2021

Preprint

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Background: Depression and anxiety are common mental health conditions for elderly population. Understanding the trajectory developments of them will help us implementing treatments and interventions.Aims: This study aims to identify depression and anxiety trajectories in the elderly, evaluate the interrelationship of these conditions, and recognize trajectory-predicting characteristics.Methods: Group-based dual trajectory modeling (GBDTM) was applied to the data of 3,983 individuals, aged 65 years or older who participated in the Korean Health Panel Study between 2008 and 2015. Logistic regression was used to identify the association between characteristics and trajectory groups.Results: Four trajectory groups from GBDTM were identified in both the depression and anxiety outcomes. Depression has: “low-flat (87.0%)”, “low-to-middle (8.8%)”, “low-to-high (1.3%)” and “high-stable (2.8%)” trajectory groups. Anxiety has: “low-flat (92.5%)”, “low-to-middle (4.7%)”, “high-to-low (2.2%)” and “high-curve (0.6%)” trajectory groups. Interrelationship between depression and anxiety were identified. Members of the high-stable depression group were more likely to have “high-to-low” or “high-curved” anxiety trajectories. Female sex, the presence of more than three chronic diseases, and having income generating activity were significant factors in depression and anxiety.Conclusions: Dual trajectory analysis of depression and anxiety in older adults shows that when one condition is present, the probability of the other is increased. Sex, having more chronic disease, and income generating activity might be at increased risks for both depression and anxiety. Health policy decision-makers can use our findings in developing strategies for prevention of both depression and anxiety in older adults.

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Prevalence and factors affecting the level of depression, anxiety, and stress in hospitalized patients with a chronic disease

Cited by 35 publications

References 46 publications

Does Endometriosis Disturb Mental Health and Quality of Life? A Systematic Review and Meta-Analysis

Does Endometriosis Disturb Mental Health and Quality of Life? A Systematic Review and Meta-Analysis

Xinkeshu Improves Endothelial Function and Augments Reendothelialization Capacity in Coronary Artery Disease with Anxiety/Depression

A Group-based Dual Trajectory of Depression and Anxiety in Older Adults: An 8-year Follow-up of Population-based Study

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