Prevalence and Factors Associated with Hepatic Iron Overload in Obese Individuals Undergoing Bariatric Surgery: a Cross-Sectional Study

Jesus, Rafael Nascimento de; Callejas, Guilherme Hoverter; Concon, Matheus Mathedi; Braga, João Gabriel Romero; Marques, Rodolfo Araújo; Chaim, Felipe David Mendonça; Gestic, Martinho Antônio; Ramos, Almino Cardoso; Chaim, Élinton Adami; Cazzo, Everton

doi:10.1007/s11695-020-05003-3

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…In the present study, we also found that 12% of patients with liver biopsy performed during surgery also had BD disorder. Iron overload can be present in both NAFLD and alcohol-associated liver disease 39 . Patients with BD had a higher iron overload, mainly due to mesenchymal deposits in the sinusoidal cells.…”

Section: Discussionmentioning

confidence: 99%

“…Iron overload can be present in both NAFLD and alcohol-associated liver disease. 39 Patients with BD had a higher iron overload, mainly due to mesenchymal deposits in the sinusoidal cells. This association can be related to several mechanisms: (1) increased iron absorption and dysregulation of iron-related proteins mediated by alcohol consumption 40 ; (2) ethanol exposure promoting iron absorption by downregulating hepcidin expression, and iron uptake by upregulating the expression of transferrin receptor in hepatocytes; (3) ethanol upregulating iron-dependent cell death namely ferroptosis 40 ; (4) systemic inflammation in response to BD.…”

Section: Discussionmentioning

confidence: 99%

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Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality

Alvarado-Tapias,

Martí-Aguado,

Gómez-Medina

et al. 2024

Hepatology Communications

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Background and Aims: Alcohol use disorder has been reported in patients undergoing bariatric procedures, but the pattern of alcohol consumption has not been evaluated. We investigated the prevalence, risk factors, and impact of binge drinking (BD) at the time of surgery and during follow-up. Methods: A prospective, longitudinal study of subjects undergoing bariatric surgery was included in the LABS-2 registry between 2006 and 2009. Participants with AUDIT questionnaire at the time of surgery and a minimum of 12 months follow-up were included. BD was defined as consuming ≥5 drinks on at least 1 occasion in the previous month. Liver biopsies were obtained during bariatric procedures in not all cases. Survival analysis was performed with the adjusted Cox regression model and competing risk. Results: A total of 2257 subjects were included, with a median follow-up of 79 months. The prevalence of BD at time of surgery was 12%, and it raised up to 23% during follow-up. Patients with BD predominantly had a binge eating disorder (OR=1.35 [95% CI: 1.04–1.76]), regularly consumed fast food [OR=1.4 (95% CI: 1.07–1.85)] and used other drugs (OR=2.65 [95% CI: 1.74–4.04]). Within liver biopsies evaluation, BD showed higher hepatic iron deposits (OR=3.00 [95% CI: 1.25–7.21]). BD at the time of surgery was associated with a higher risk of BD during follow-up (OR=10.49 [95% CI: 7.86–14.00]) and long-term mortality (HR: 3.21 [95% CI: 1.67–6.18]). Specific causes of death in these patients with BD were liver disease (p=0.020), suicide (p=0.015), neoplasms (p=0.034), and respiratory (p=0.025). Conclusions: The prevalence of BD in patients undergoing bariatric surgery is high and increases the risk of postoperative liver disease, suicides, and long-term mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality

Alvarado-Tapias,

Martí-Aguado,

Gómez-Medina

et al. 2024

Hepatology Communications

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“…Outro fator que pode ser observado é a distância euclidiana que foi maior para GX (3,82) do que para CMC (1,83), observando também que os vetores MSPA, MSR e ALT estão correspondendo à utilização de GX, confirmando a eficiência deste biopolímero em manter as células do microrganismo viáveis para realizar a promoção de crescimento da planta.…”

Section: Pseudomonas Fluorescensunclassified

Clima Organizacional: Conceito-Ferramenta Para a Gestão Da Qualidade

Machado¹,

Oliveira²,

Castro³

2022

Conceitos E Metodologias De Integração Em Ciências Biológicas E Da Saúde 2

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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“…End-stage renal disease (ESRD) is the last stage of chronic kidney disease requiring dialysis. The aging of the world's population and improved survival in the ESRD population has resulted in a gradual increase in the prevalence of ESRD [1,2]. As many as 9.7 million patients worldwide required dialysis in 2010 and the number is projected to double by 2030 [3].…”

Section: Introductionmentioning

confidence: 99%

The influence of propofol-based total intravenous anesthesia on postoperative outcomes in end-stage renal disease patients: A retrospective observation study

et al. 2021

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Background To determine whether the anesthetic method of propofol total intravenous anesthesia (TIVA) is associated with postoperative outcome in ESRD patients, we evaluated the incidence of postoperative major adverse cardiac events (MACE), comparing propofol TIVA versus anesthesia with volatile anesthesia in ESRD patients. Methods Retrospectively, we identified cases with ESRD patients who underwent surgery under general anesthesia. Patients were divided into those who received only volatile anesthesia (volatile group) and those who received only propofol TIVA (TIVA group). The incidence of MACE and potential confounding variables were compared separately in a univariate logistic model and subsequently by multivariate logistic regression. Results Among the 2576 cases in ESRD patients, 1374 were in the TIVA group and 1202 were in the volatile group. The multivariate analysis included 12 factors, including the anesthesia method, of which five factors were significant. Factors that were associated with a significantly lower MACE risk included preoperative chloride concentration (OR: 0.96; 95% CI, 0.92–0.99), baseline SBP (OR: 0.98; 95% CI, 0.98–0.99), and propofol TIVA (OR: 0.37; 95% CI, 0.22–0.60). Conclusions We inferred that the anesthetic method associated with the postoperative outcome in patients with ESRD.

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Prevalence and Factors Associated with Hepatic Iron Overload in Obese Individuals Undergoing Bariatric Surgery: a Cross-Sectional Study

Cited by 9 publications

References 29 publications

Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality

Binge drinking at time of bariatric surgery is associated with liver disease, suicides, and increases long-term mortality

Clima Organizacional: Conceito-Ferramenta Para a Gestão Da Qualidade

The influence of propofol-based total intravenous anesthesia on postoperative outcomes in end-stage renal disease patients: A retrospective observation study

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