Prevalence and Factors Associated With Metabolic Syndrome in Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus

Zonana-Nacach, Abraham; Santana-Sahagún, Ernesto; Jiménez-Balderas, Francisco Javier; Camargo-Coronel, Adolfo

doi:10.1097/rhu.0b013e31816b2faa

Cited by 80 publications

(75 citation statements)

References 16 publications

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“…In most of these studies, MetS prevalence was found to be higher in patients with RA than in control groups (21,(24)(25)(26)(27)(28)(29)(30). Other, smaller studies have reported either higher MetS prevalence in the control group (31) or no difference between the RA and control groups (32).…”

Section: Discussionmentioning

confidence: 98%

Prevalence of metabolic syndrome and degree of cardiovascular disease risk in patients with Psoriatic Arthritis

Yazısız

Behlül

et al. 2017

Eur J Rheumatol

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Objective: The aim of this study was to identify the prevalence of metabolic syndrome (MetS) and degree of cardiovascular disease (CVD) risk in patients with psoriatic arthritis (PsA). Material and Methods:We performed a cross-sectional study on 102 adult patients with PsA and a control group of 102 patients with rheumatoid arthritis (RA). MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Federation (IDF) criteria. The Framingham risk scores of 10-year risk of CVDs and coronary heart disease (CHD) were also calculated.Results: The prevalence of MetS was higher in patients with PsA than in those with RA, according to the NCEP-ATP III (40.6% vs.24.7%, respectively; p=0.019) and IDF (46.8% vs. 27.9%, respectively; p=0.05) criteria. The prevalence of MetS was higher in female patients with PsA (p=0.009) than in male patients. A significantly increased prevalence of hypertriglyceridemia was determined in patients with PsA (p=0.019). No significant difference existed between the two groups with respect to 10-year CVD (p=0.333) and CHD (p=0.798) risks. Additionally, there were no significant differences between the clinical subtypes of PsA with regard to MetS (p=0.229). Conclusion:MetS prevalence increased in patients with PsA compared with those with RA, whereas the risks were similar for CVDs and CHD. For this reason, optimal protection measures should be taken and guidelines should be applied to achieve adequate metabolic control in patients with PsA.

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Section: Discussionmentioning

confidence: 98%

Prevalence of metabolic syndrome and degree of cardiovascular disease risk in patients with Psoriatic Arthritis

Yazısız

Behlül

et al. 2017

Eur J Rheumatol

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“…The prevalence of overweight and obesity patients is common in RA and SLE (14)(15)(16)(17)(18)(19). However, in our study, the prevalence of obesity was not higher in the BD group than in the HC group and general population (25).…”

Section: Discussionmentioning

confidence: 99%

“…Although the etiology of BD is not fully known, immune abnormality is thought to be associated with the development and maintenance of BD (12,13). The prevalence of obesity in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is reported to be higher (14)(15)(16)(17)(18)(19). In RA and SLE, the potential association of obesity with the progression of the diseases has been researched (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Low prevalence of obesity in Behçet’s disease is associated with high obestatin level

Koca¹,

Kara²,

Özgen³

et al. 2017

Eur J Rheumatol

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Objective: Chronic inflammatory diseases are associated with altered body composition. Ghrelin has anti-inflammatory effects, and its level is altered in obesity and inflammatory diseases. The aim of the study was to evaluate the prevalence of obesity and ghrelin and obestatin levels in patients with Behçet's disease (BD). Material and Methods:One hundred and forty-three (143) ). In addition to the routine evaluations (fasting blood glucose, lipid profile, and kidney and liver function tests), serum acylated-ghrelin (AG), unacylated-ghrelin (UAG), total ghrelin (TG) and obestatin levels were analyzed. Student's t-test and chi-square test were used for statistical analysis.Results: The prevalence of obesity was relatively lower in the BD group than in the HC group (12.6% vs. 20.5%, p=0.089). Serum ghrelin levels were similar in the BD and HC groups (p>0.05 for all) although the obestatin level was higher in the BD group compared to the HC group (p<0.001). Serum UAG, TG and obestatin levels were lower in obese BD patients (n=18) than non-obese BD patients (p=0.027, p=0.014 and p=0.001, respectively). Conclusion:The obestatin level was high and the prevalence of obesity was low in the BD group. Moreover, obese BD patients had low obestatin levels. These results suggest that obestatin may protect BD patients from obesity.

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“…Several studies have also shown high MetS prevalence in patients with SLE in developed countries. MetS classification according to National Cholesterol Educational Program (NCEP ATP-III) showed a prevalence of 16% in Netherlands [17], from 17% to 20% in Spain [18,19] [20]. In Italy [21], also using World Health Organization (WHO) classification, it was found a prevalence of 28%.…”

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confidence: 99%

“…In female lupus patients, MetS has been associated with lower income and government health insurance. [18,23,27] Moreover, susceptibility factors to the syndrome include genetic and racial factors, aging, endocrine disorders, lifestyle, and diet habits and MetS prevalence over time has been verified in the general population [28]. Thus, it is likely that MetS prevalence is also increasing in SLE patients.…”

mentioning

confidence: 99%

Metabolic Syndrome in Systemic Lupus Erythematosus

Iriyoda¹,

Lozovoy²

2016

J Obes Eat Disord

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Prevalence and Factors Associated With Metabolic Syndrome in Patients With Rheumatoid Arthritis and Systemic Lupus Erythematosus

Cited by 80 publications

References 16 publications

Prevalence of metabolic syndrome and degree of cardiovascular disease risk in patients with Psoriatic Arthritis

Prevalence of metabolic syndrome and degree of cardiovascular disease risk in patients with Psoriatic Arthritis

Low prevalence of obesity in Behçet’s disease is associated with high obestatin level

Metabolic Syndrome in Systemic Lupus Erythematosus

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