Abstract:Objectives: to identify the prevalence and factors associated with the development of acute kidney injury in critically ill patients. Methods: a cross-sectional study, conducted from June 2018 to August 2019. The Kidney Disease Improving Global Outcomes was used to classify acute kidney injury. A significant value was set at p<0.05. Results: a total of 212 patients were included, of whom 35.8% evolved into an acute kidney injury. Patients with acute kidney injury had hypertension, higher levels on severit… Show more
“…Verificou-se relação entre óbito e pacientes internados em UTIs. Similarmente um estudo realizado no Nordeste brasileiro entre pacientes hospitalizados em UTI detectou que mais da metade dos pacientes com IRA foi a óbito (56,1%) [22]. Pacientes críticos internados em UTI apresentam quase 50% a mais de chance de desfecho fatal quando comparados a pacientes sem IRA [23,24].…”
Objetivo: Analisar a prevalência de mortalidade de pacientes hospitalizados com injúria renal aguda e fatores associados. Métodos: Estudo de coorte retrospectivo realizado com pacientes adultos internados em um hospital terciário do Sul do Brasil. Realizou-se análise bivariada e, a seguir, modelo de regressão de Poisson com variância robusta. Resultados: A média de idade foi de 59,0 anos, já a dos que evoluíram para óbito foi de 62,4 anos. A mortalidade por injúria renal aguda associou-se com internação em UTI (p-valor = 0,037), paciente crítico (p-valor ≤ 0,001), pior estadiamento (p-valor = 0,001), indicação de hemodiálise (p-valor = 0,001), duas ou mais causas etiológicas (p-valor = 0,004) e progressão da idade (p-valor ≤ 0,001). Conclusão: A identificação precoce dos fatores de risco para mortalidade por injúria renal aguda poderá contribuir para a implementação de medidas para redução do óbito entre pacientes hospitalizados.
“…Verificou-se relação entre óbito e pacientes internados em UTIs. Similarmente um estudo realizado no Nordeste brasileiro entre pacientes hospitalizados em UTI detectou que mais da metade dos pacientes com IRA foi a óbito (56,1%) [22]. Pacientes críticos internados em UTI apresentam quase 50% a mais de chance de desfecho fatal quando comparados a pacientes sem IRA [23,24].…”
Objetivo: Analisar a prevalência de mortalidade de pacientes hospitalizados com injúria renal aguda e fatores associados. Métodos: Estudo de coorte retrospectivo realizado com pacientes adultos internados em um hospital terciário do Sul do Brasil. Realizou-se análise bivariada e, a seguir, modelo de regressão de Poisson com variância robusta. Resultados: A média de idade foi de 59,0 anos, já a dos que evoluíram para óbito foi de 62,4 anos. A mortalidade por injúria renal aguda associou-se com internação em UTI (p-valor = 0,037), paciente crítico (p-valor ≤ 0,001), pior estadiamento (p-valor = 0,001), indicação de hemodiálise (p-valor = 0,001), duas ou mais causas etiológicas (p-valor = 0,004) e progressão da idade (p-valor ≤ 0,001). Conclusão: A identificação precoce dos fatores de risco para mortalidade por injúria renal aguda poderá contribuir para a implementação de medidas para redução do óbito entre pacientes hospitalizados.
Background
Acute kidney injury (AKI) is a serious complication of the Corona Virus Disease of 2019 (COVID-19). However, data on its magnitude and risk factors among hospitalized patients in Ethiopia is limited. This study aimed to determine the magnitude of AKI and associated factors among patients admitted for severe COVID-19 pneumonia.
Methods
An institution-based retrospective cross-sectional study was conducted among 224 patients admitted to Jimma University Medical Center in Ethiopia for severe COVID-19 pneumonia from May 2020 to December 2021. Systematic random sampling was used to select study participants. Medical records were reviewed to extract sociodemographic, clinical, laboratory, therapeutic, and comorbidity data. Bivariable and multivariable logistic regressions were performed to examine factors associated with AKI. The magnitude of the association between the explanatory variables and AKI was estimated using an adjusted odds ratio (AOR) with a 95% confidence interval (CI), and significance was declared at a p-value of 0.05.
Results
The magnitude of AKI was 42% (95% CI: 35.3–48.2%) in the study area. Mechanical ventilation, vasopressors, and antibiotics were required in 32.6, 3.7, and 97.7% of the patients, respectively. After adjusting for possible confounders, male sex (AOR 2.79, 95% CI: 1.3–6.5), fever (AOR 6.5, 95% CI: 2.7–15.6), hypoxemia (AOR 5.1, 95% CI: 1.4–18.9), comorbidities (AOR 2.8, 95% CI: 1.1–7.0), and severe anemia (AOR 10, 95% CI: 1.7–65.7) remained significantly associated with higher odds of AKI.
Conclusion
The burden of AKI among patients with severe COVID-19 pneumonia is high in our setting. Male sex, abnormal vital signs, chronic conditions, and anemia can identify individuals at increased risk and require close monitoring and prevention efforts.
“…Acute kidney injury (AKI), a very common complication of sepsis, is a sudden decrease in renal function within a short period caused by various etiologies [ 5 ]. Studies have shown that patients in the intensive care unit (ICU) are more likely to develop AKI due to clinical instability and previous risk factors, including advanced age, sepsis, hypovolemia, surgery, and nephrotoxic medication [ 6 , 7 ]. Up to 50% of AKI cases are associated with sepsis, and up to 60% of patients with sepsis develop AKI [ 8 , 9 ].…”
Background
This study aimed to discuss the diagnostic value of multi-parameter ultrasound evaluation in sepsis complicated with acute kidney injury (AKI).
Methods
Patients were divided into an AKI group (
n
= 50) and a non-injury group (
n
= 50) based on the presence of AKI. The clinical characteristics were collected, and renal function parameters between the two groups were compared, including 24-h urine volume, serum creatinine, urea, serum cystatin C (CysC), renal parenchymal thickness (RPT), renal artery resistance index (RI), and multi-parameter ultrasound scoring (MPUS). Additionally, logistic regression analysis was conducted to determine the influencing factors of sepsis complicated with AKI. The prediction value was evaluated using a receiver operating characteristic (ROC) curve.
Results
In the AKI group, creatinine, CysC, urea, MPUS score, RPT, and RI values were significantly higher, while the 24-h urine volume was lower than those in the non-injury group (
p
< 0.01). Moreover, multivariate logistic analysis indicated that high CysC and RI values were independent risk factors, whereas high 24-h urine volume and low MPUS were independent protective factors for sepsis-induced AKI. The ROC curve demonstrated that RI (AUC = 0.906) was more effective than 24-h urine volume (AUC = 0.797), CysC (AUC = 0.730), and MPUS (AUC = 0.794) in identifying sepsis-induced AKI.
Conclusion
High RI values increase the risk of sepsis-induced AKI, whereas low MPUS may reduce it. RI showed high diagnosis values for sepsis complicated with AKI.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
