Prevalence and Factors Associated with Toxoplasma Gondii Immunization among Pregnant Women in Douala â Cameroon

Nguefack, Charlotte Tchente; Meumeu, Isabelle Kenmegne; Ngaba, Guy Pascal; Kongnyuy, Eugene J; Njamen, Théophile Nana; Gregory, Halle Ekane; Mboudou, Emile Télesphore

doi:10.4172/2325-9795.1000248

Cited by 9 publications

(16 citation statements)

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“…In the coastal region of Cameroon, a rate of 71.8% (out of 170 pregnant women) was reported in the health district of Limbe (10). Values close to the rates reported above were also recorded in 2016; 54.5% (out of 178 women of child-bearing age) at Njinikom, north-western region (11) and 78.6% (out of 327 pregnant women) in Douala (12). All these studies emphasize the need to sensitize pregnant women to the disease and its mode of transmission during their prenatal follow-up, in order to reduce the risk of first infection during their pregnancy.…”

Section: Introductionsupporting

confidence: 76%

Seroprevalence of Toxoplasmosis and associated risk factors in pregnant women at the Protestant Hospital, Mbouo-Bandjoun, Cameroon

Todjom¹,

Tsapi²,

Gamago³

et al. 2019

Af J Clin Exp Micro

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Background: Toxoplasmosis is a common worldwide infection caused by the protozoan Toxoplasma gondii. In Cameroon, several recent studies have reported high seroprevalence of this parasitosis in various hospitals (Douala, Limbe, Njinikom and Yaoundé). The aim of this study was to determine whether this high prevalence of toxoplasmosis might occur in other regions of the country. Methodology: Serological tests by the indirect Enzyme Linked Immunosorbent Assay (ELISA) for IgG and IgM were carried out on 200 pregnant women (36 HIV-positive and 164 HIV-negative) at the Protestant Hospital of Mbouo-Bandjoun in western Cameroon to determine the presence of Toxoplasma gondii infection and to identify the risk factors associated with seropositivity of the subjects. Results: The overall seroprevalence of anti-Toxoplasma antibodies was 45.5%. The prevalence rate was 80.5% in the HIV-positive group (47.2% IgG, 22.2% IgM and 11.1% IgG + IgM) and 37.8% in the HIV-negative group (25.6%, 9.7% and 2.4% respectively). Using a multivariate logistic regression analysis, the secondary level of educational, presence of HIV infection, and frequency of close contacts with cats were significantly associated with the prevalence of IgG and/or IgM antibodies. Conclusion: Compared with previous reports of human toxoplasmosis in Cameroon, the prevalence in our study showed a decrease in the disease occurrence. Further studies are needed to determine whether this decrease is localised to our study or a general phenomenon currently affecting the country.

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Section: Introductionsupporting

confidence: 76%

Seroprevalence of Toxoplasmosis and associated risk factors in pregnant women at the Protestant Hospital, Mbouo-Bandjoun, Cameroon

Todjom¹,

Tsapi²,

Gamago³

et al. 2019

Af J Clin Exp Micro

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“…Following Cochran's formula (1963) [ 35 ], a total sample size of 342 was calculated from a previous Toxoplasma seroprevalence of 65.5% among pregnant women in Douala, Littoral Region of Cameroon [ 22 ]. Sampling of pregnant women was done by convenience, and 360 pregnant women were approached with consent forms to sign after study was explained to them, but 310 fully consented to the study.…”

Section: Methodsmentioning

confidence: 99%

“…Existing reports showed a prevalence of 68.4% in Brazil [ 14 ], 6.4% in South Africa [ 15 ], 42.5% in Malaysia [ 16 ], 36.7% in France [ 17 ], 92.5% in Ghana [ 18 ], 5.87% in Zambia [ 19 ], 30.9% in Tanzania [ 20 ], and 20.3% in Burkina Faso [ 21 ]. In different regions of Cameroon, seroprevalence of over 50% have been reported [ 22 – 25 ], while other regions have had seroprevalence rates of less than 50% [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Gestational and Neonatal Toxoplasmosis as well as Risk Factors in Yaoundé, Cameroon

Ayeah

Oladokun

Sumbele

et al. 2022

Journal of Parasitology Research

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Background. Toxoplasmosis, caused by Toxoplasma gondii in pregnant women, is a significant public health problem due to risk of mother to child transmission. The aim of the study was to determine the seroprevalence of toxoplasmosis in pregnant women and corresponding cord blood among women attending Biyem-Assi and CASS Nkoldongo hospitals in Yaoundé, Cameroon. Methods. An institutional based cross-sectional study was conducted between June 2019 and May 2020 on 300 pregnant women from late second trimester to third trimester. A total of 259 cord blood samples were collected at birth from these women. Toxoplasma gondii-specific IgG and IgM antibodies in maternal and cord blood were detected using the Toxoplasma Enzyme Immunosorbent Assay kit, and potential risk factors captured through questionnaire were identified using binary logistic regression model. Statistical significance was measured at P < 0.05 . Results. The overall seroprevalence of gestational and neonatal toxoplasmosis was 80% and 88%, respectively. IgG seropositivity was 72.7%, IgM only was 1.3% and cooccurrence of IgG/IgM was 6% amongst pregnant women. Out of 259 newborn cord bloods, 72.2% were positive for IgG only, 8.9% for IgM only, and 23.9% for both IgG/IgM. Pregnant women 15-24 years ( AOR = 4.6 , P = 0.011 ) and women with primary level of education ( AOR = 3.9 , P = 0.042 ) were significantly at risk of infection with Toxoplasma gondii. Conclusion. Gestational and neonatal toxoplasmosis appears to be more common with higher risk of infection in younger women and less educated women. Hence, these findings will serve as baseline data for further investigations on mother to child transmission of toxoplasmosis in Yaoundé and the need for reinforcement of pregnant women toxoplasmosis-related health measures.

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“…The studies qualified for the review were conducted in 12 countries in Africa. Thirteen (36.1%) of these studies were from eastern Africa [19][20][21][22][23][24][25][26][27][28][29][30][31], 12 (33.3%) from western Africa [12,[32][33][34][35][36][37][38][39][40][41][42], 5 (13.9%) from northern Africa [43][44][45][46][47], five (13.9%) from central Africa [17,18,[48][49][50] and one (2.8%) were from southern Africa [11]. The overall number of study participants included in this meta-analysis was 10,701 and 4,242 pregnant women for IgG and IgM respectively.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

WITHDRAWN: Sero-epidemiology of Toxoplasma gondii and risk factors among pregnant women in Africa

2021

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Prevalence and Factors Associated with Toxoplasma Gondii Immunization among Pregnant Women in Douala â Cameroon

Cited by 9 publications

References 0 publications

Seroprevalence of Toxoplasmosis and associated risk factors in pregnant women at the Protestant Hospital, Mbouo-Bandjoun, Cameroon

Seroprevalence of Toxoplasmosis and associated risk factors in pregnant women at the Protestant Hospital, Mbouo-Bandjoun, Cameroon

Seroprevalence of Gestational and Neonatal Toxoplasmosis as well as Risk Factors in Yaoundé, Cameroon

WITHDRAWN: Sero-epidemiology of Toxoplasma gondii and risk factors among pregnant women in Africa

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Prevalence and Factors Associated with Toxoplasma Gondii Immunization among Pregnant Women in Douala â Cameroon

Cited by 9 publications

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Seroprevalence of Toxoplasmosis and associated risk factors in pregnant women at the Protestant Hospital, Mbouo-Bandjoun, Cameroon

Seroprevalence of Toxoplasmosis and associated risk factors in pregnant women at the Protestant Hospital, Mbouo-Bandjoun, Cameroon

Seroprevalence of Gestational and Neonatal Toxoplasmosis as well as Risk Factors in Yaoundé, Cameroon

WITHDRAWN: Sero-epidemiology of Toxoplasma gondii and risk factors among pregnant women in Africa

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Prevalence and Factors Associated with Toxoplasma Gondii Immunization among Pregnant Women in Douala â Cameroon