Prevalence and factors associated with dyslipidemia after liver transplantation

Abstract

Prevalence and factors associated with dysliPidemia after liver transPlantation rev assoc med Bras 2014; 60(4):365-372 365Original articlePrevalence and factors associated with dyslipidemia after liver transplantation Conflict of interest: noneObjective: to determine the prevalence of abnormal total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides in patients undergoing liver transplantation (LTx) and to identify predictors of these disorders. Methods: cross-sectional study to assess the prevalence of dyslipidemia in patients undergoing LTx. Demographic, socioeconomic, clinical, anthropometric and dietetic data were collected to determine the association with dyslipidemia using univariate and multivariate statistical analysis. Results: 136 patients were evaluated, 68.1% of which had at least one type of dyslipidemia. The triglyceride level was high in 32.4% of cases, with low HDL in 49.3% of patients and high LDL levels in only 8.8%. High total cholesterol was observed in 16.2% of the study population and was associated with the recommendation for transplantation due to ethanolic cirrhosis (OR = 2.7) and a greater number of hours slept per night (OR = 1.5). Conclusion: many patients presented dyslipidemia after transplantation, demonstrating the need for interventions in relation to modifiable factors associated with dyslipidemias that can mitigate or prevent these disorders.

Dietary Management for Dyslipidemia in Liver Transplant Recipients

“…Calorie needs were based on the resting energy expenditure obtained by the standard method for each patient plus +35 kcal/kg/day for early LT recipients and +30 kcal/kg/day for late LT recipients 23 . The individualized diet was prescribed following recommendations of specific guidelines for prevention of atherosclerosis, and consisted of 25% of the energy value in total fat, ≤7% of the total energy value in saturated fat and <200 mg/day of cholesterol 27 . …”

Nutritional Intake after Liver Transplant: Systematic Review and Meta-Analysis

“…Four studies categorised dietary intake in terms of food groups (Table S2, Supplementary Materials) [9,27,29,43]. It was inappropriate to pool the averages for fruit and vegetable intake as a conversion to arithmetic means and SDs produced implausible values.…”

“…The main risk factors for post-transplant death include post-transplant diabetes and hypertension [2]. Cardiovascular disease risk factors are prevalent in liver transplant recipients (LTR): 67-87% are overweight or obese, 41-63% have hypertension, 21-45% have diabetes, and 31-70% have dyslipidaemia [3][4][5][6][7][8][9][10][11][12]. These risk factors are modifiable by changes in lifestyle, including diet [13].…”

Drogas Imunossupressoras Afetam Os Núcleos Hipotalâmicos Envolvidos Na Ingestão Alimentar ? Estudo Experimental

“…Além disso, o ganho de peso após o transplante hepático pode ter diversos fatores como balanço energético positivo 21 , estilo de vida sedentário 13 , desenvolvimento de estado hipometabólico 23 e uso de terapias imunossupressoras 7 .…”

“…Besides, weight gain after liver transplantation may have different factors, such as positive energy balance 21 , sedentary lifestyle 13 , development of hypometabolic state 23 , and use of immunosuppressive therapies 7 .…”