Prevalence and Features of Keratitis with Quantitative Polymerase Chain Reaction Positive for Cytomegalovirus

Cytomegalovirus-associated anterior segment infection

“…During the same period, 51 eyes of 48 patients with CMV endotheliitis (Figure 3) were analyzed, and all were from Asian populations [6,8,[16][17][18][19][20][21][22][23][24]. Unlike eyes with anterior uveitis, the KPs in eyes with corneal endotheliitis tended to be pigmented, and were often arranged in a linear or coin-shaped pattern (Table 2).…”

“…It is interesting that 20 eyes had been treated previously for hypertensive anterior uveitis and were receiving corticosteroids at the time of diagnosis of the endotheliitis [6,[16][17][18]23]. Furthermore, two eyes with anterior uveitis had been noted to have concomitant endotheliitis lesions [7].…”

“…Of further interest, 14 eyes were diagnosed following corneal graft surgery [6,[17][18][19]22] and one eye had a history of both previous uveitis and graft [21]. These eyes had initially been thought to display endothelial rejection, until linear or coin-shaped KPs were noted, the endothelial cell count decreased unexpectedly or the edema worsened despite an increase in immunosuppressive therapy [19,22].…”

“…The source of the CMV infection in these eyes is uncertain. The indications for the initial graft included keratoconus [22], posterior polymorphous dystrophy, pseudophakic bullous keratopathy [18,19], herpetic keratouveitis, Fuchs uveitis syndrome [19], Fuchs endothelial dystrophy [17], recurrent corneal endotheliitis [17] and corneal opacities [17]. Other than the eye that received a graft for keratoconus, whether these eyes already had CMV endotheliitis prior to the graft, the CMV was transmitted from the donor or the prolonged immunosuppressive therapy caused a reactivation of latent CMV, cannot be determined.…”

Ganciclovir-Resistant Cytomegalovirus (CMV) Retinitis in a Patient with Wild-Type CMV in Her Plasma

“…For our patient, we performed quantitative real-time PCR on aqueous humor to monitor our patient's disease progression, similar to previous reports of quantitative PCR in the evaluation and monitoring of other intraocular viral infections (6,8,9,13). Primers and probes used were previously described by Sanchez and Storch (12).…”