Prevalence and Financial Burden of Digestive Diseases in a Commercially Insured Population

Mathews, Simon C.; Izmailyan, Sergey; Brito, Frances A.; Yamal, José‐Miguel; Mikhail, Osama; Revere, Lee

doi:10.1016/j.cgh.2021.06.047

Cited by 30 publications

(23 citation statements)

References 33 publications

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“…In the general population, the incidence rate of AP ranges from 10 to 44 per 100,000/year, 6 being one of the leading causes of hospital admission and expenses for digestive diseases 7 . Patients with IBD seem to be at increased risk for acute pancreatitis.…”

Section: Resultsmentioning

confidence: 99%

Systematic review—pancreatic involvement in inflammatory bowel disease

Massironi

Fanetti

Viganò

et al. 2022

Aliment Pharmacol Ther

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Summary Background Inflammatory bowel disease (IBD) is a chronic inflammatory immune‐mediated disorder of the gut with frequent extra‐intestinal complications. Pancreatic involvement in IBD is not uncommon and comprises a heterogeneous group of conditions, including acute pancreatitis (AP), chronic pancreatitis (CP), autoimmune pancreatitis (AIP) and pancreatic exocrine insufficiency (PEI); however, data on such an association remain sparse and heterogeneous. Method PubMed/MEDLINE and EMBASE databases were searched for studies investigating pancreatic involvement in patients with IBD. Results Four thousand one hundred and twenty‐one records were identified and 547 screened; finally, 124 studies were included in the review. AP is the most frequent pancreatic manifestation in IBD; the majority of AP cases in IBD are due to gallstones and drugs but cases of idiopathic AP are increasingly reported. AIP is a rare disease, but a strong association with IBD has been demonstrated, especially for type 2 and ulcerative colitis. The pathogenetic link between IBD and AIP remains unclear, but an immune‐mediated pathway seems plausible. An association between CP and PEI with IBD has also been suggested, but data are to date scarce and conflicting. Conclusion This is the first systematic review of the association between IBD and pancreatic diseases. Gallstones and drugs should be considered the most probable causes of AP in IBD, with type 2 AIP also being possible.

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Section: Resultsmentioning

confidence: 99%

Systematic review—pancreatic involvement in inflammatory bowel disease

Massironi

Fanetti

Viganò

et al. 2022

Aliment Pharmacol Ther

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“…Digestive system diseases, including fatty liver diseases (FLDs), liver and intestinal ischemia-reperfusion injury (IRI), hepatitis B virus (HBV), pancreas diseases, and inflammatory bowel diseases (IBDs), are the most common clinical diseases. 653 , 654 Increasing evidence has suggested that changes in SIRT activity and expression are associated with etiology of various digestive diseases. 280 , 655 As discussed below, SIRTs play an important role in maintaining the homeostasis of digestive system function and participating in the occurrence and development of digestive diseases (Fig.…”

Section: Introductionmentioning

confidence: 99%

The sirtuin family in health and disease

Zhang

Chen

et al. 2022

Sig Transduct Target Ther

288

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Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory disease, and other conditions. Moreover, identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules, which can modify SIRT activity. Furthermore, several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples, and supplementation of SIRT modulators might have diverse impact on physiological function in different participants. In this review, we introduce the history and structure of the SIRT protein family, discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family, elaborate on the regulatory roles of SIRTs in human disease, summarize SIRT inhibitors and activators, and review related clinical studies.

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“…Recurrent acute pancreatitis (RAP) is a common clinical problem, among the first causes of emergency and expense for gastroenterological pathologies in US [11,12]. Common complications such as the evolution to episodes of acute pancreatitis, the onset of diabetes or the progression to chronic pancreatitis represent an eventuality with a serious impact on the patient's quality of life and on healthcare costs [13]. About one-third of cases of acute pancreatitis have a recurrence, resulting in the onset of chronic pancreatitis over time [14].…”

Section: Recurrent Acute Pancreatitismentioning

confidence: 99%

Imaging of Pancreatitis

Morana¹,

Beleù²,

Nistri³

et al. 2023

Multidisciplinary Management of Acute and Chronic Pancreatitis

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Imaging of pancreatitis is very complicated. Correct detection of the various forms of pancreatitis is essential for adequate early therapy. In acute pancreatitis, imaging is useful for diagnosis, but above all for the research of causes and any complications. In autoimmune forms, imaging raises clinical suspicion and guides the response to therapy and the search for associated pathologies. In chronic pancreatitis, imaging is essential for grading, differential diagnosis with neoplastic diseases and follow-up. The classical CT and MRI methods play a fundamental role in this sense, being increasingly supported by modern special techniques such as S-MRCP and T1-mapping. Finally, interventional radiology today represents one of the main minimally invasive methods for the diagnosis and treatment of complications.

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Prevalence and Financial Burden of Digestive Diseases in a Commercially Insured Population

Cited by 30 publications

References 33 publications

Systematic review—pancreatic involvement in inflammatory bowel disease

Systematic review—pancreatic involvement in inflammatory bowel disease

The sirtuin family in health and disease

Imaging of Pancreatitis

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