Prevalence and gene frequencies of phenylthiocarbamide (PTC) taste sensitivity, ABO and Rhesus factor (Rh) blood groups, and haemoglobin variants among a Nigerian population

Alimba, Chibuisi G.; Adekoya, Khalid O.; Oboh, B. O.

doi:10.1016/j.ejmhg.2010.10.003

Cited by 25 publications

(23 citation statements)

References 14 publications

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“…These findings are consistent with the trend reported in a study carried out in the Eastern region of Ghana (Kretchy et al, ). Similar studies by Loua, Lamah, Haba, and Camara (), Alimba, Adekoya, and Oboh () and Randriamanantany et al () also reported a similar trend of O > B>A > AB in a Guinean, Nigerian and Madagascan populations, respectively. The predominance of the O phenotype observed in this study is common in other African populations, but there are some slight differences in the distribution of A and B phenotypes.…”

Section: Discussionsupporting

confidence: 80%

Frequency of ABO/Rhesus (D) blood groupings and ethnic distribution in the Greater‐Accra region of Ghana, towards effective blood bank inventory

Doku

Agbozo

Annor

et al. 2019

Int J Immunogenetics

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Knowledge on blood group phenotypes is of key importance in clinical practice. It used in blood transfusion practice to determine the direction of recruitment of voluntary donors as required for each population within a country, and for disease association and population genetics studies. This study aimed at reporting the frequency of ABO and Rhesus (Rh) groups in the population of the Greater‐Accra region of Ghana and amongst their various ethnic groups. A retrospective study in 11 main hospitals within the region was done. Data collected provided information on the blood group status of persons (both blood donors and recipients) who visited the selected hospitals. Medical records used were within the years 2012–2017. A total of 42,317 (26,802 males and 15,515 females) data were retrieved and analysed. The frequencies of the blood groups O, A, B and AB were 50.0%, 24.3%, 20.7% and 5.0%, respectively. Rhesus‐positive to negative ratio was 93.2%/6.2%. Frequencies of blood group O was highest (49.1%–53.6%) in all ethnic groups. The second most dominant blood group was B (24.2%–25.4%) in the Ga‐Adamgbe, Akan and Ewe ethnic groups, whilst blood group A (25.0%–26.9%) was the second most dominant in the Northerners and non‐Ghanaians. Blood group distribution amongst gender and different age groups showed no significant differences but followed the same pattern for the general population. The study provides data on the ethnic distribution and frequency of ABO and Rhesus blood groupings in the Greater‐Accra region of Ghana. It also informs the need for blood banks in the region to increase the proportion of stockpiled Rhesus‐positive blood groups especially for O, B and A that may be high in demand.

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Section: Discussionsupporting

confidence: 80%

Frequency of ABO/Rhesus (D) blood groupings and ethnic distribution in the Greater‐Accra region of Ghana, towards effective blood bank inventory

Doku

Agbozo

Annor

et al. 2019

Int J Immunogenetics

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“…Gene frequencies with respect to ABO system for the present study can be shown with a general formula O > B > A > AB which does not seem to deviate from the studies carried out previously in different parts of the world. [3,14] reported that blood group O was the most common blood group and blood group AB was the least common blood group in different ethnic groups. The findings from this study are in accordance with the aforementioned studies that also reported AB as the least prevalent blood group [3,[16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…[3,14] reported that blood group O was the most common blood group and blood group AB was the least common blood group in different ethnic groups. The findings from this study are in accordance with the aforementioned studies that also reported AB as the least prevalent blood group [3,[16][17][18][19]. Thus, the gene segregation for ABO systems always followed a particular pattern for its distribution in different ethnic groups with exceptional cases.…”

Section: Discussionmentioning

confidence: 99%

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Frequency distribution of ABO and Rh (D) blood group alleles in Silte Zone, Ethiopia

Tesfaye

Petros

Andargie

2015

Egyptian Journal of Medical Human Genetics

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Background: Frequency distribution of blood groups is important as it is used in modern medicine, genetic research, anthropology, and tracing ancestral relations of humans. The ABO and Rh blood groups are the most important blood groups despite the long list of several other blood groups discovered so far.Aim of the study: To study and document the frequency of ABO and Rh (D) blood groups in three ethnic groups of Silte Zone, Ethiopia.Subjects and methods: ABO and Rh (D) typing was carried out during 2012 and a total of 441 students from both genders were randomly selected from Silte Secondary and Preparatory School, SNNPR, Ethiopia. Finger prick blood samples from both genders were tested for ABO and Rh (D) blood groups by the open slide test method. A drop of each of the antisera, anti-A, anti-B and anti-D was added and mixed with each blood sample and rocked gently for 60 s to observe agglutination.Results: The blood group ''O'' was predominant (36.73%, 40.14%, 46.26% in Sodo, Silte and Meskan ethnic groups, respectively) in all the Rh positive subjects whereas blood group ''A'' was predominant (5.4%) in the Rh negative subjects only in the Sodo ethnic group among the three ethnic groups. The percentage of Rh (D) positive and negative subjects was 91. 16%, 93.19%, 91.84% and 8.84%, 6.81%, 8.16% in Sodo, Silte and Meskan ethnic groups, respectively.Conclusion: The frequency of ABO blood groups in both Rh positive and negative subjects among the three ethnic groups of the Silte Zone, Ethiopia was O > A > B > AB, except in the Sodo ethnic group where the blood group A was the commonest among Rh negative subjects.Ó 2014 Production and hosting by Elsevier B.V. on behalf of Ain Shams University.

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“…Igbeneghu et al [10] reported 30.0% non-tasters and non-tasting allelic frequency of 0.55. Alimba et al [13] reported 29.4% and 0.54 respectively and Bakare et al [14] reported 22.6% and 0.48 respectively. There was a significant higher incidence of PTC tasters than nontasters in the control group which is in line with many previous studies involving general population [9].…”

Section: Discussionmentioning

confidence: 96%

Phenylthiocarbamide(PTC) Taste Perception among Pulmonary Tuberculosis Patients in Southwest Nigeria

Igbeneghu¹,

B.A²,

J.A³

et al. 2016

SJAMS

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Abstract:Understanding the genetic variation existing among individuals in relation to common diseases is necessary for classifying, comparing and managing them. In Nigeria, tuberculosis is common but we are not aware of any study on the association between phenylthiocarbamide (PTC) taste perception and tuberculosis. This present study was carried out to determine whether or not inability to taste PTC was associated with pulmonary tuberculosis. A total of 220 individuals comprising 113 tuberculosis patients (test group) and 107 apparently healthy subjects (control group) participated in this study. Tasters and non-tasters were determined among the participants using PTC taste strips. Of the 113 tuberculosis patients, 52 (46.0%) were tasters and 61 (54.0%) were non-tasters while 76 (71.0%) and 31 (29.0%) of the 107 control subjects were tasters and non-tasters respectively. Non-tasters of PTC were significantly more associated with tuberculosis patients than control subjects (χ 2 = 14.13, df = 1, p < 0.001). This study shows that inability to taste PTC is significantly associated tuberculosis.

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Prevalence and gene frequencies of phenylthiocarbamide (PTC) taste sensitivity, ABO and Rhesus factor (Rh) blood groups, and haemoglobin variants among a Nigerian population

Cited by 25 publications

References 14 publications

Frequency of ABO/Rhesus (D) blood groupings and ethnic distribution in the Greater‐Accra region of Ghana, towards effective blood bank inventory

Frequency of ABO/Rhesus (D) blood groupings and ethnic distribution in the Greater‐Accra region of Ghana, towards effective blood bank inventory

Frequency distribution of ABO and Rh (D) blood group alleles in Silte Zone, Ethiopia

Phenylthiocarbamide(PTC) Taste Perception among Pulmonary Tuberculosis Patients in Southwest Nigeria

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