Prevalence and genetic determinant of drug-resistant tuberculosis among patients completing intensive phase of treatment in a Tertiary Referral Center in Nigeria

Mohammad, Aminu Bashir; Iliyasu, Garba; Habib, Abdulrazaq G.

doi:10.4103/2212-5531.201883

Cited by 1 publication

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“…There were 476, 774 reported cases of HIV-positive TB (46% of the estimated incidence), of whom 85% were on antiretroviral therapy (ART). A total of 129, 689 people were started on treatment for drug-resistant TB, a small increase from 125, 629 in 2015 but only 22% of the estimated incidence; treatment success remains low, at 54% globally.The increasing emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) in the era of human immunodeficiency virus (HIV) infection presents a major setback in efforts to effectively control TB (Aminu et al, 2017). This study describes the epidemiologic characteristics of tuberculosis cases during 2015-2018 in the area and also provides scientific information for TB prevention and control in the future.…”

Section: Discussionmentioning

confidence: 99%

Transmission pattern and the role of DOTS clinic in the control strategies of Tuberculosis in Kano, Nigeria

Takalmawa,

Mukhtar,

Taura

et al. 2023

dujopas

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Tuberculosis (TB) is a major public health concern not only in developing nations but globally and the World Health Organization (WHO) estimated 10.4 million incident cases of TB and 1.67 million TB deaths in 2017. The study was conducted in Infectious Disease Hospital (IDH), Kano, a reference health facility for infectious disease of public health importance. The aim of the study was to determine the transmission pattern of Mycobacterium tuberculosis complex (MTBC) strains and the role played by Directly Observed Therapy Short course (DOTS) clinic in the control of TB. Of the 945 case-patients enrolled, 625 (66.1%) were males and 320 (33.9%) were females. The mean age of patients in years was 32.8 ± 13.8 SD and the median age was 30 years (range 3-95 years). Incidence of TB among presumptive cases was 15.0%. There was a fairly consistent increase in TB prevalence from 2015 (11.0%), 2016 (11.5%), 2017 (10.0%) and 2018 (36%). Pulmonary TB was diagnosed in 884 (93.5%) while Extra-Pulmonary TB accounted for 6.5%. New cases of TB within the study period were 819 (86.7%) and while 126 (13.3%) were relapse TB cases. Treatment outcome that included patients described as cured or have completed treatment successfully (smear negative) were recorded in 811 (85.8%) cases. DOTS clinic has improved TB detection rate through the years and consequently played a big supervisory role in TB treatment and control strategy in the state.

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Section: Discussionmentioning

confidence: 99%

Transmission pattern and the role of DOTS clinic in the control strategies of Tuberculosis in Kano, Nigeria

Takalmawa,

Mukhtar,

Taura

et al. 2023

dujopas

View full text Add to dashboard Cite

show abstract

Prevalence and genetic determinant of drug-resistant tuberculosis among patients completing intensive phase of treatment in a Tertiary Referral Center in Nigeria

Abstract: There is a need to strengthen the laboratory capacity for the diagnosis of TB and drug resistance testing and make these services available, affordable, and accessible to the patients who need them.

Cited by 1 publication

References 2 publications

Transmission pattern and the role of DOTS clinic in the control strategies of Tuberculosis in Kano, Nigeria

Transmission pattern and the role of DOTS clinic in the control strategies of Tuberculosis in Kano, Nigeria

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