Prevalence and genetic diversity of HCV among HIV-1 infected individuals living in Ahvaz, Iran

Teimoori, Ali; Ebrahimi, Saeedeh; Keshtkar, Narges; Khaghani, Soheila; Salmanzadeh, Shokrollah; Ghafari, Shokouh

doi:10.1186/s12879-019-4052-x

Cited by 8 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, HCV genotype 4 has spread in parts of Europe due to variations in the populace structure, ways of transmission and migration. The characteristics of genotype 4 infection and proper therapeutic programs are not well described 27 . Genotype 4 is mostly found in Northern Africa and the Middle East (Egypt, Iran).…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic analysis of the 5ʹ untranslated region of HCV from cirrhotic patients in Khyber Pakhtunkhwa, Pakistan

Ullah

Rehman

Ahmad

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Hepatitis C virus (HCV), a small, single-stranded RNA virus with a 9.6 kb genome, is one of the most common causes of liver diseases. Sequencing of the 5ʹ untranslated region (UTR) is usually used for HCV genotyping, but it is less important in numerous subtypes due to its scarce sequence variations. This study aimed to identify genotypes using the 5ʹ UTR of HCV from cirrhotic patients of Khyber Pakhtunkhwa (KP). Serum RNA samples (44) were screened by real time PCR to determine the HCV viral load. Nested PCR was performed to identify cDNA and the 5ʹ UTR. The HCV 5′ UTR was sequenced using the Sanger method. MEGA-7 software was used to analyze evolutionary relatedness. After 5ʹ UTR sequencing, 26 samples (59%) were identified as genotype 3, and 2 samples (6%) were identified as genotypes 1, 2 and 4. The most predominant genotype was 3a, and genotype 4 was rarely reported in the phylogenetic tree. Analysis of the HCV 5ʹ UTR is an efficient alternative method for confirmation of various genotypes. Phylogenetic analysis showed that genotype 3 was dominant in the area of KP, Pakistan.

show abstract

Section: Discussionmentioning

confidence: 99%

Phylogenetic analysis of the 5ʹ untranslated region of HCV from cirrhotic patients in Khyber Pakhtunkhwa, Pakistan

Ullah

Rehman

Ahmad

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Despite strong similarity in evasion tactics employed, courses and outcomes of evolution may differ markedly among viruses. A dramatic example is that HIV persists indefinitely in any infected individual, while HCV can be spontaneously cleared in around 30% of those invaded (Thomas et al, 2009), even though the genetic diversity of HCV in a chronically infected person is comparable to or higher than that of HIV (McNearney et al, 1992;Martell et al, 1992;Simmonds et al, 1993;Pybus et al, 2001;Chen et al, 2003;Simmonds, 2004;Forbi et al, 2014;Teimoori et al, 2019). In addition, broadly neutralizing antibodies (bnAbs)-capable of recognizing a vast array of mutant strains-evolve against both viruses (Burton and Hangartner, 2016;Flyak et al, 2018), presenting a potential solution to counter rapid viral evolution.…”

Section: Introductionmentioning

confidence: 99%

Coevolutionary transitions emerging from flexible molecular recognition and eco-evolutionary feedback

Sheng

Wang

2021

iScience

View full text Add to dashboard Cite

Summary Highly mutable viruses evolve to evade host immunity that exerts selective pressure and adapts to viral dynamics. Here, we provide a framework for identifying key determinants of the mode and fate of viral-immune coevolution by linking molecular recognition and eco-evolutionary dynamics. We find that conservation level and initial diversity of antigen jointly determine the timing and efficacy of narrow and broad antibody responses, which in turn control the transition between viral persistence, clearance, and rebound. In particular, clearance of structurally complex antigens relies on antibody evolution in a larger antigenic space than where selection directly acts; viral rebound manifests binding-mediated feedback between ecology and rapid evolution. Finally, immune compartmentalization can slow viral escape but also delay clearance. This work suggests that flexible molecular binding allows a plastic phenotype that exploits potentiating neutral variations outside direct contact, opening new and shorter paths toward highly adaptable states.

show abstract

“…Human immunodeficiency virus-HCV coinfection is associated with a markedly high risk of developing cirrhosis, hepatoma, and liver fibrosis progression [ 18 , 19 ]. In the natural history of chronic HCV, viral and host factors play a considerable role in the course of HCV.…”

mentioning

confidence: 99%

Hepatitis C Virus Coinfection in People With Human Immunodeficiency Virus in Iran: A Systematic Review and Meta-Analysis

Razavi-Amoli

Alipour

2022

Open Forum Infectious Diseases

View full text Add to dashboard Cite

HCV co-infection is associated with higher mortality and morbidity in people with HIV (PWH). We aimed to characterize the epidemiology and factors associated with HCV co-infection among PWH in Iran. In this systematic review, we searched three English databases (MEDLINE, SCOPUS, Embase) and two Farsi databases (Scientific Information Database, and Magiran) for studies that measured the prevalence of HCV co-infection among PWH, published between 2000 and January 1, 2021. We included studies with a minimum sample size of 5 PWH. Reviews, editorials, conference abstracts, theses, studies with no relevant data, and unclear serological assays were excluded. We summarized the HCV co-infection prevalence by random-effect meta-analysis and assessed the sources of heterogeneity by a meta-regression model. Of the 858 records identified, 69 eligible studies with 12996 PWH were included. Overall, HCV co-infection prevalence was 64% (95%CI 58–69). The prevalence was higher among older (mean age >= 35y) PWH (69%, 95%CI 64-74), and PWH who inject drugs (77%, 95%CI 71-82). Furthermore, we found that co-infection was higher among studies conducted between 2000-2014 (67%, 95%CI 59-75) versus 2015-2020 (57%, 95%CI 50-64). The prevalence of HCV co-infection is high in Iranian PWH, with significant geographical variations. HCV screening and treatment among PWH are warranted to avoid the future burden of HCV-related liver damage, cancer, and mortality.

show abstract

Prevalence and genetic diversity of HCV among HIV-1 infected individuals living in Ahvaz, Iran

Cited by 8 publications

References 30 publications

Phylogenetic analysis of the 5ʹ untranslated region of HCV from cirrhotic patients in Khyber Pakhtunkhwa, Pakistan

Phylogenetic analysis of the 5ʹ untranslated region of HCV from cirrhotic patients in Khyber Pakhtunkhwa, Pakistan

Coevolutionary transitions emerging from flexible molecular recognition and eco-evolutionary feedback

Hepatitis C Virus Coinfection in People With Human Immunodeficiency Virus in Iran: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About