Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Korean Women: A Multicenter Study

Abstract

Background : DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods : A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results : Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. Highrisk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions : The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.

Significance of HPV-58 Infection in Women Who Are HPV-Positive, Cytology-Negative and Living in a Country with a High Prevalence of HPV-58 Infection

“…Furthermore, HPV-58 has been found in a relatively high proportion of patients with high-grade cervical dysplasia in China [25]. In Korean women, HPV-58 is the second most common type of HPV in women with abnormal cervical cytology [12]. In this study, we show that HPV-58 infection is associated with a high risk of developing HSIL among women with negative cytological results.…”

“…Overall HPV-58 is the third most common oncogenic type in Asia, but causes only 3.3% of all global cervical cancer cases [9], [10], [11]. In Korea, HPV-58 is the second most common type diagnosed in women with abnormal cytological specimens (10.8% of all abnormal cytological specimens) [12].…”

Uncommon and Rare Human Papillomavirus Genotypes Relating to Cervical Carcinomas

“…Despite screening based on a national cervical cancer screening program and recent introduction of HPV vaccination, uterine cervical cancer is the second most common female malignancy worldwide 1,13. Cervical cancer remains a major health burden in Korea 2,5…”

“…HPV is a double-stranded DNA virus infecting basal epithelial cells of cutaneous or mucosal tissues 4. Epidemiologic investigations have clearly established a causal link between HPV infection and development of cervical cancer, and recent use of a sensitive molecular method for detection of HPV DNA revealed HPV infection in more than 80% of squamous intraepithelial lesions 3,5. More than 140 different HPV genotypes have been identified and sequenced, and approximately 40 HPV genotypes are known to act as oncogenic genotypes.…”

Prevalence of Human Papilloma Virus subtypes 52,56,58,59 and 66 among Yemeni Patients with Cervical Cancer

“…Overall HPV type 58 is the third most common oncogenic type in Asia, but causes only 3.3% of all global cervical cancer cases (Smith et al 2007;Bao et al 2008). In Korea, HPV-58 is the second most common type diagnosed in women with abnormal cytological specimens (10.8% of all abnormal cytological specimens) (Hong et al 2009). Though the higher prevalence of HPV subtype 58 in East Asia is not completely understood, genetic characteristics and HPV subtype 58 variants with diverse oncogenicity are supposed to play a part (Chan, 2012;Chan et al 2002).…”