Prevalence and genotype distribution of high‐risk HPV infection among women in Beijing, China

Abstract

Cervical cancer (CC) is highly associated with high‐risk human papillomavirus (HPV) infection and genotype distribution of high‐risk HPV (HR‐HPV) infection varies greatly in different regions. Clinical specimens were collected from 46 365 patients at Beijing Friendship Hospital, Capital Medical University from January 2017 to December 2020. HPV DNA genotype testing was performed using real‐time PCR. The infection rates based on disease group were compared using the χ 2 test. The linear‐by‐linear association test and gamma value were used to assess the changes in HPV prevalence over calendar year and age group. A total of 10 514 women were infected with HR‐HPV, with an overall positive rate of 22.7%. The most prevalent HR‐HPV types were HPV52, 58, 16, 51, and 66, and HPV59 had a higher prevalence except for HPV16, 58, and 52 in the CC group. Single infection of HR‐HPV was dominant among different disease groups. The infection rate of HR‐HPV decreased first and then increased from below 20 years old to over 60 years old. There were significant differences in the HR‐HPV infection rates among the age and disease groups. Our findings demonstrate that the genotype distribution of HR‐HPV varied with age and diseases. The HR‐HPV genotypes prevalence was found to be directly useful for local governments to promote HPV targeted vaccination in the study region.

Comparison of primary cytology, primary HPV testing and co-testing as cervical cancer screening for Chinese women: a population-based screening cohort

“…Overall, HR-HPV prevalence in the study population at baseline was 14.4%, which was lower than 18.0%, as concluded by pooled analysis by Zhao et al from 17 population-based studies in rural China in 2010 25. In our study, the prevalence of HPV slightly declined in middle ages (40–49 years), yet increased among the oldest people (60–64 years), which are consistent with other studies in China26 27 or in some Latin America/Caribbean populations 28. A meta-analysis of 1 million women from five continents showed that age-specific HPV distribution presented with a first peak at younger ages (<25 years) and, in the Americas and Africa, a rebound at older ages (≥45 years) 29.…”

Prevalence and genotype distribution of HPV infection among women in Xiamen, China

“…Among the participants in this study, the overall HPV positive rate including HR-HPV and LR-HPV was 15.13%, which was consistent with the study demonstrated the overall prevalence of HPV infection in China (15.54%) [16].Some results from other cities of China also reported the similar HPV prevalence [17,18,19,20,21]. However, the HPV prevalence reported was higher than Shannan (8.16%) [22] and Xinjiang (9.34%) [23] but was lower than Zhejiang Province (22.3%) [24], Beijing (22.7%) [25], Jiangxi Province (22.49%) [26] and Heilongjiang Province (27.1%) [27]. The variability of HPV prevalence may be accounted to diverse geographical condition and economy developmental level.…”

The prevalence and distribution of human papillomavirus in 4267 Turkish women with or without cervical lesions: A hospital‐based study

“…The high‐risk group includes HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82, infection with these types may potentially progress into invasive cervical cancer 11 . The overall prevalence of HPV infection worldwide is estimated to be nearly 10% (<3%–26%) 12 . In patients with cervical cancer the prevalence of high‐risk HPV DNA is more than 95% 13 .…”

“…11 The overall prevalence of HPV infection worldwide is estimated to be nearly 10% (<3%-26%). 12 In patients with cervical cancer the prevalence of high-risk HPV DNA is more than 95%. 13 Thus, the detection of high-risk HPV (HR-HPV) has become increasingly attractive as a primary screening tool for cervical cancer due to its sensitivity and cost-effectiveness.…”