Prevalence and genotype distribution of human papillomaviruses in Sichuan, China

Wen, Qiang; Chenzhang, Yuwei; Huang, Jibin; Chen, Zuyi; Ding, Xianping; Wang, Tao; Mu, Xuemei; Xu, Jing

doi:10.1016/j.flm.2017.06.005

Cited by 2 publications

(5 citation statements)

References 17 publications

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“…The most prevalent HR-HPV subtype was HPV 16 which was consistent with other settings 21 , 22 observations whereas its prevalence increased with increase in age. The ratio of HIV positive to HIV negative screened to attain the required sample size was approximately 1:2 for women aged 18–59 years.…”

Section: Discussionsupporting

confidence: 89%

Cytological physiognomies and genotype distribution of human papillomaviruses among HPV/HIV co-infected and HPV mono-infected women

et al. 2021

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Background: Co-infection of High Risk Human Papillomavirus (HR-HPV) and HIV is thought to favour initiation of intraepithelial squamous cell lesion and subsequent progression to cervical carcinoma. Objectives: Evaluation of cytological physiognomies in relation to possible age influence and the genotype distribution of human papillomaviruses among HPV/HIV co-infected and HPV monoinfected women in Kisii, Kenya. Methods: The case-control study enrolled 42 HPV/HIV co-infected and 42 HPV monoinfected women. Cervical swabs were collected in ThinPrep vials for HPV tying and cytological analysis. HPV subtypes were assayed by Xpert® HPV system (GXHPV-CE-10). Results: Mono-infected women aged 30-39 years had the highest proportion of low grade squamous intraepithelial lesion (LSIL) at 14 (16.67%) while the co-infected aged 50-59 years had the highest proportion of high grade squamous intraepi- thelial lesion (HSIL) at 9 (10.71%). HPV-16 genotype was the most predominant and it increased with age rise. Older coin- fected and mono-infected women (>40 years) had HSIL and LSIL as the most predominant cytological grade respectively. Conclusion: The predominance of HPV-16 and HPV-18/45 genotypes in the study setting is a consideration that would benefit targeted prophylactic vaccination programs. HPV testing and cervical cancer screening for young and older women on a regular basis ought to be reinforced. Keywords: Human immunodeficiency virus (HIV); Human Papillomavirus (HPV); co-infection; genotype; cytology.

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Section: Discussionsupporting

confidence: 89%

Cytological physiognomies and genotype distribution of human papillomaviruses among HPV/HIV co-infected and HPV mono-infected women

et al. 2021

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“…It also suggests that HPV 58 and HPV 52 deserve more attention in Asia 40,41 . The situation in Northwest China is also unique with a high prevalence of HPV 53 and HPV 61 after the three most common HPV genotypes mentioned above 17,28–30 . Although two LR‐HPV genotypes, HPV 6 and 11, were contained in some vaccines, HPV 61 was the predominant LR‐HPV genotype in Northwest China in this study.…”

Section: Discussionmentioning

confidence: 57%

“…40,41 The situation in Northwest China is also unique with a high prevalence of HPV 53 and HPV 61 after the three most common HPV genotypes mentioned above. 17,[28][29][30] Although two LR-HPV genotypes, HPV 6 and 11, were contained in some vaccines, HPV 61 was the predominant LR-HPV genotype in Northwest China in this study. All the results provide a basis for developing next -generation HPV vaccines.…”

Section: Discussionmentioning

confidence: 63%

“…However, according to the data from WHO, HPV 16, 18, 33, 52, and 58 are the five most common HPV genotypes in patients with cervical cancer in Eastern Asia 16 . Data from several provinces in China, such as Guangdong, Jiangsu, Sichuan, Yunnan, Hunan, and Shandong, suggest that the HPV genotypes with high prevalence in different provinces are different 17–21 . Up to now, studies on HPV genotypes are all conducted in Southwest, Central South, Southeast, or Eastern China, not in Northwest China.…”

Section: Introductionmentioning

confidence: 99%

“…16 Data from several provinces in China, such as Guangdong, Jiangsu, Sichuan, Yunnan, Hunan, and Shandong, suggest that the HPV genotypes with high prevalence in different provinces are different. 17 , 18 , 19 , 20 , 21 Up to now, studies on HPV genotypes are all conducted in Southwest, Central South, Southeast, or Eastern China, not in Northwest China. In Northwest China, the less‐developed area, the epidemiology of HPV is considered to be different from that of the developed areas.…”

Section: Introductionmentioning

confidence: 99%

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Age‐specific prevalence and genotype distribution of human papillomavirus in women from Northwest China

et al. 2022

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Background: Human papillomavirus (HPV) is the leading cause of cervical cancer with more than 200 genotypes. Different genotypes have different potentials in causing premalignant lesions and cervical cancers. In this study, we investigated the age-specific prevalence and genotype distribution of HPV genotypes in Northwest China. Materials and Methods: We recruited 145,918 unvaccinated women from Northwest China for population-based HPV DNA screening test during June 2015 to December 2020. And a lab-based test was performed for each volunteer by flow fluorescent technology to identify the genotypes of HPV. Results:The overall infection rate of HPV was 22.97%. With the participants divided into 12 groups according to age, a bimodal curve of infection rate was obtained. And the two peaks appeared in the younger than 20 group and 61-65 group, respectively. The five most common HPV genotypes included HPV 16, 58, 52, 53 and 61 in all participants, which were in descending order of frequency.Among women younger than 25 years old, HPV 6 and 11 were more common and even higher than some genotypes mentioned above. Among women older than 65 years old, HPV 18 and 66 were more common than or as high as the six most common genotypes in all populations. Additionally, the distribution of single and multiple infections in each age group was also different. Conclusion:The baseline prevalence and genotype distribution of HPV in Northwest China was uncovered for the first time. Age was related to the epidemiology of different HPV genotypes. All the results would be of great significance for future healthcare services.

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Prevalence and genotype distribution of human papillomaviruses in Sichuan, China

Cited by 2 publications

References 17 publications

Cytological physiognomies and genotype distribution of human papillomaviruses among HPV/HIV co-infected and HPV mono-infected women

Cytological physiognomies and genotype distribution of human papillomaviruses among HPV/HIV co-infected and HPV mono-infected women

Age‐specific prevalence and genotype distribution of human papillomavirus in women from Northwest China

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