Prevalence and Genotypes of α- and β-Thalassemia Carriers in Hong Kong — Implications for Population Screening

Lau, Yu‐Lung; Chan, Li-Chong; Chan, Yuk-Yin A.; Ha, Shau Yin; Yeung, Ching‐Hei; Waye, John S.; Chui, David H.K.

doi:10.1056/nejm199705013361805

Cited by 193 publications

(145 citation statements)

References 19 publications

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“…Some examples include a-and b-thalassaemia in Hong Kong, 19 haemoglobinopathies in Marseille, 20 cystic fibrosis (CF) in Israel 21 and TSD and CF in Australia 15,22 and Canada. 14 In addition, it has been demonstrated in the programme in Sydney, Australia, that carrier screening is comparable in cost to prenatal carrier screening for CF.…”

Section: Genetic Carrier Screening Programmes In Schoolsmentioning

confidence: 99%

It's ‘back to school’ for genetic screening

et al. 2006

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Implementation of population genetic screening programmes requires consideration of strategies for reaching the greatest proportion of the target population in order to achieve maximum awareness. This article reviews the current strategy of school-based population genetic screening programmes. The school environment is an ideal setting for offering relevant genetic screening programmes as it provides an opportunity to engage people at a time when they are exposed to a range of educational experiences and are sufficiently mature to be involved in decision-making processes. Such programmes allow all students, not only those studying biology, an opportunity to be educated and experience genetic screening in a supportive environment, ultimately increasing understanding and empowering students. While the major form of genetic screening in schools has been for reproductive health information (eg carrier screening for TaySachs disease and cystic fibrosis), genetic screening in schools for other conditions may be a timely proposition.

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Section: Genetic Carrier Screening Programmes In Schoolsmentioning

confidence: 99%

It's ‘back to school’ for genetic screening

et al. 2006

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“…In Hong Kong, 5% of the population are α-thalassemia carriers 1 . Fetuses affected by homozygous α-thalassemia-1 have deficient α-globin chain production.…”

Section: Introductionmentioning

confidence: 99%

Nuchal translucency in fetuses affected by homozygous α‐thalassemia‐1 at 12–13 weeks of gestation

Lam

Tang

Lee

et al. 1999

Ultrasound in Obstet & Gyne

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“…1 Our patient escaped the screening program because her mother failed to seek antenatal care. With immediate resuscitation and intensive support, she survived without major complications.…”

Section: Discussionmentioning

confidence: 93%