Prevalence and geographical distribution of canine hemotropic mycoplasma infections in Mediterranean countries and analysis of risk factors for infection

Novacco, Marilisa; Meli, Marina L.; Gentilini, Fabio; Marsilio, Fulvio; Ceci, Chiara; Pennisi, Maria Grazia; Lombardo, Gabriella; Lloret, Albert; Santos, L. F. P; Carrapiço, Tiago; Willi, Barbara; Wolf, Godelind; Lutz, Hans; Hofmann‐Lehmann, Regina

doi:10.1016/j.vetmic.2009.09.069

Cited by 81 publications

(105 citation statements)

References 22 publications

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“…Interestingly, in southern Europe, Novacco et al (2010) observed that young mongrel dogs living in shelters were significantly more predisposed towards infection by hemoplasmas. On the other hand, in Tanzania and Trinidad and Tobago , male dogs with free access to outdoor environments were significantly more likely to present infection by hemoplasmas.…”

Section: Resultsmentioning

confidence: 99%

“…Although contact with saliva was not confirmed as a risk factor for infection, a study by Sazaki et al (2008) showed that dogs of the Tosa breed, which are usually known as fighting dogs, are more prone to infection in Japan. Maggi et al (2013) Immunosuppression and weakness caused by other concomitant diseases have been identified as important factors that favor infection by these agents (PRYOR & BRADBURY, 1975;KRAKOWKA, 1977;GRETILLAT, 1981;NOVACCO et al, 2010;ROURA et al, 2010). In Brazil, coinfections by M. haemocanis and other tick-borne pathogens in dogs have also been reported (TRAPP et al, 2006;RAMOS et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

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Occurrence of Mycoplasma haemocanis in dogs infested by ticks in Campo Grande, Mato Grosso do Sul, Brazil

Soares

Echeverria

Pazzuti

et al. 2016

Rev. Bras. Parasitol. Vet.

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Hemotropic mycoplasmas in dogs, such as Mycoplasma haemocanis, have been described worldwide. Recently, these pathogens have been reported to be causative agent of zoonosis. It is known that its transmission may occur through the action of blood-sucking arthropods (e.g. ticks or fleas), through blood transfusion, contaminated fomites and/or transplacentally. In Brazil, M. haemocanis is present in practically all regions and the tick Rhipicephalus sanguineus sensu lato is suspected the main vector. In the municipality of Campo Grande, state of Mato Grosso do Sul, there is little information about infection of dogs by M. haemocanis, or on the main epidemiological features associated with it. Thus, the aim of the present study was to determine the occurrence of M. haemocanis among dogs infested by ticks and to assess possible associations with some epidemiological factors. The polymerase chain reaction (PCR) and DNA sequencing were used to analyze dog blood samples (n = 94). DNA from M. haemocanis was detected in four samples. No significant associations were observed with any epidemiological parameter analyzed here. However, the results from this study confirm that this pathogen is circulating in this region and should be considered in the differential diagnosis of diseases among anemic dogs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Occurrence of Mycoplasma haemocanis in dogs infested by ticks in Campo Grande, Mato Grosso do Sul, Brazil

Soares

Echeverria

Pazzuti

et al. 2016

Rev. Bras. Parasitol. Vet.

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“…This is particularly noted in countries with warmer climates and those with endemic Rhipicephalus sanguineus (brown dog tick) populations. 1,[9][10][11][12]17,25 Clinical disease, however, remains uncommon and is rarely reported in animals that are immunocompetent and that are not splenectomized. 13,16 As a result of the low incidence of clinical disease, there is little available information on monitoring of infection in clinical cases, and few reports exist that examine the efficacy of antibiotic therapies against canine hemoplasmas.…”

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confidence: 99%

Use of Real-Time Quantitative Polymerase Chain Reaction to Monitor Antibiotic Therapy in a Dog with Naturally Acquired Mycoplasma haemocanis Infection

Hulme-Moir

Barker

Stonelake³

et al. 2010

J VET Diagn Invest

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Abstract. Mycoplasma haemocanis is a hemotropic bacterium that can be associated with acute hemolytic disease in immunocompromised or splenectomized dogs. The present case report describes for the first time the use of real-time quantitative polymerase chain reaction (qPCR) to monitor M. haemocanis infection in a splenectomized dog. The report also describes the application of real-time qPCR for the analysis of deoxyribonucleic acid extracted from stained blood films. The analysis of blood films from the time of initial presentation allowed a retrospective confirmation of M. haemocanis infection. The M. haemocanis copy numbers remained high throughout antibiotic treatment of this dog. A decline in copy numbers was only recorded after 11 months of therapy, when improvements in clinical and hematological indices were also noted. Clearance of infection was not achieved, and the dog remained positive for M. haemocanis at 3.5 months postcessation of antibiotic therapy. Cytological examination of blood films for the presence of organisms was insensitive for the detection of parasitemia.

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Section: Análise Estatísticaunclassified

“…Novacco et al, 2010). A ocorrência por CMhp encontrada foi a menor dentre os estudos de prevalência Kenny et al, 2004;Novacco et al, 2010; Tennant et al, 2011;, exceto na Suíça (Wengi et al, 2008) Kenny et al, 2004;Novacco et al, 2010;Roura et al, 2010; Tennant et al, 2011) Não houve associação significativa entre infecção por hemoplasmas e idade, conforme anteriormente relatado Kenny et al, 2004; Tennant et al, 2011;Wengi et al, 2008).Um estudo prévio encontrou que machos são mais propensos a infecção por Mhc do que fêmeas, o que está de acordo com os achados do presente estudo, uma vez que associação próxima a significativa (p=0,06) foi encontrada para infecção por Mhc e gênero masculino.Não foi encontrada associação significativa entre infecção por hemoplasmas e VG ou presença de anemia, o que de acordo com estudos prévios Hetzel et al, 2012;Novacco et al, 2010;Roura et al, 2010) Mycoplasma haemofelis (Mhf), 'Candidatus Mycoplasma haemominutum' (CMhm) and 'Candidatus Mycoplasma turicensis' (CMt) are agents of feline haemoplasmosis and can induce anaemia in cats. This study aimed to determine the prevalence and phylogeny of haemoplasma species in cats from Brazil's capital and surrounding areas, and whether correlation with haematological abnormalities existed.…”

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Estudo das infecções por hemoplasmas em cães e gatos domésticos

Aquino¹

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vii AGRADECIMENTOSMeu maior obrigada a minha mãe, Lourdes, por ser não só mãe, mas também pai, amiga, torcedora, guerreira e porto seguro. Ela é meu principal exemplo de ser humano. Dedico e ofereço a ela todas minhas conquistas.Muito obrigada por ser minha maior incentivadora e, principalmente, por acreditar na minha capacidade, até quando eu mesma não acredito.Obrigada ao meu marido Darien por ser grande exemplo de otimismo, bondade e força, por me apoiar incondicionalmente e acreditar em mim.Obrigada pela vida que decidimos trilhar juntos e por tanto amor! Obrigada vó Diva, minha segunda mãe, pelos cuidados e orações.Elas têm funcionado! Obrigada aos meus irmãos, Eduardo, Marlos e Rovena, por toda oportunidade de aprendizado, por serem exemplos tão diferentes e se preocuparem comigo. Aos meus sobrinhos Guilherme e Felipe, que em tão pouco tempo já conquistaram tanto amor em nossos corações e pelas fofuras diárias! Obrigada pela amizade verdadeira, Patrícia, Bruna e Daniela! E por me ensinarem em todos os momentos de convívio e pelo apoio incondicional a qualquer hora! Obrigada Tatiana por todo apoio moral, técnico e intelectual de sua mente brilhante! Obrigada pela paciência e pelas inúmeras ajudas! Obrigada aos colegas de laboratório por toda ajuda e apoio.Meus agradecimentos a minha orientadora, Giane, pela oportunidade oferecida e pela orientação ao longo de tantos anos. Obrigada por ter acreditado no que eu podia oferecer e pela liberdade que tive ao longo dessa pesquisa.Obrigada à CAPES pelo apoio financeiro para que eu pudesse me dedicar exclusivamente a pesquisa e para que eu realizasse o doutorado viii sanduíche na Universidade de Bristol. Obrigada à FAPDF por financiar a apresentação desse projeto em congressos internacionais.Por fim, sou muito grata ao que o doutorado me proporcionou:conhecimento, descobertas, oportunidades e novos horizontes! Espero que esse conteúdo possa contribuir de alguma forma àqueles que se interessam pelas hemoplasmoses. ' (CMhp) are the most prevalent. The aims of the present study were to determine the occurrence and the phylogeny of haemoplasma species from cats in Brasilia and surrounding cities and from dogs in Nigeria, Africa; and assess weather any correlation existed between haemoplasma infection and haematological abnormalities. Blood samples were collected from 451 cats in different origins of Brasília, DF and from 246 dogs from Jos, Plateau State, Nigeria; submitted to erythrocyte evaluation and DNA extraction for PCR analysis and sequencing. In the cats study, haemoplasmas were found in 13.8% of 432 cats. CMhm was the most prevalent species (in 13.8% of cats), followed by Mhf (11.1%) and CMt (4.4%). Over 80% of haemoplasma-infected cats harboured two or more feline haemoplasma species: 7.1% of cats were coinfected with Mhf/CMhm, 0.4% with CMhm/CMt and 3.9% with Mhf/CMhm/CMt. Male gender was significantly associated with haemoplasma infections. No association was found between qPCR haemoplasma status and haematological variables, however CMhm relative copy nu...

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Prevalence and geographical distribution of canine hemotropic mycoplasma infections in Mediterranean countries and analysis of risk factors for infection

Cited by 81 publications

References 22 publications

Occurrence of Mycoplasma haemocanis in dogs infested by ticks in Campo Grande, Mato Grosso do Sul, Brazil

Occurrence of Mycoplasma haemocanis in dogs infested by ticks in Campo Grande, Mato Grosso do Sul, Brazil

Use of Real-Time Quantitative Polymerase Chain Reaction to Monitor Antibiotic Therapy in a Dog with Naturally Acquired Mycoplasma haemocanis Infection

Estudo das infecções por hemoplasmas em cães e gatos domésticos

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