Prevalence and heterogeneity of antiphosphatidylethanolamine antibodies in patients with recurrent early pregnancy losses

Sugi, Toshitaka; Katsunuma, Junko; Izumi, Shun-ichiro; McIntyre, John A.; Makino, Tsunehisa

doi:10.1016/s0015-0282(99)00119-3

Cited by 101 publications

(88 citation statements)

References 39 publications

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“…Anti-phosphatidylethanolamine antibodies may be a risk factor for atherosclerosis in women with RPL. It has been reported that kininogendependent IgG anti-phosphatidylethanolamine antibodies markedly increases thrombininduced platelet aggregation in vitro while kininogen independent IgG antiphosphatidylethanolamine antibodies do not augment thrombin-induced platelet aggregation (Sugi et al, 1999). However, we observed that both two types of antiphosphatidylethanolamine antibodies were associated with arterial stiffness.…”

Section: Women With Prl Associated With Antiphospholipid Antibodiescontrasting

confidence: 60%

Vascular Dysfunction in Women with Recurrent Pregnancy Loss

Nakastuka¹

2012

Recent Advances in Cardiovascular Risk Factors

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Section: Women With Prl Associated With Antiphospholipid Antibodiescontrasting

confidence: 60%

Vascular Dysfunction in Women with Recurrent Pregnancy Loss

Nakastuka¹

2012

Recent Advances in Cardiovascular Risk Factors

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“…Some of these antibodies are directed to phosphatidyl ethanolamine-binding plasma proteins, such as high molecular weight kininogen. 9 The kininogen concentration in reproductive tissues and plasma has been reported to fl uctuate during ovulation, pregnancy and parturition. 10 What governs the fl uctuation of kininogen concentrations remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

et al. 2005

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RESULTS: ACA was detected in 11 women with RSA and one fertile woman. Heterozygous C677T was detected in 59 women with RSA and 35 fertile women. Concomitant presence of ACA and C677T was found in eight women with RSA and no fertile women (p < 0.01). DISCUSSION:The meaning of the association between C677T mutation in the MTHFR gene and ACA is still not clear. It is possible that an inherited factor that alone would not strongly predispose a woman to thrombosis could, when associated with an acquired factor, start the process and increase the likelihood of thrombosis expression.CONCLUSIONS: ACA and C677T in the MTHFR gene are statistically associated with RSA. The association of these two conditions is a new fi nding in thrombogenic factors and RSA.

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“…We treated a male patient who had had chronic thromobocytopenic purpura from the age of 3 years and multiple cerebral infarctions from the age of 14 years, and in whom SNAPS with anti-PE antibodies was finally diagnosed when he was 21 years old. As mentioned above, several reports have indicated that the clinical manifestations of APS are caused by anti-PE antibodies 5 . PE is found mainly in the inner leaflets of mammalian plasma membranes, and it accounts for 20% to 50% of total phospholipids.…”

Section: Case Presentationmentioning

confidence: 91%

“…mL) and IgM antibodies (normal range <0.456 U! mL) with an enzymelinked immunosorbent assay with or without kininogens using a method previously described 4,5 . The PE was pur- Thus, the value of positivity for anti-PE antibodies in patients with SNAPS remains a controversial topic.…”

Section: Case Presentationmentioning

confidence: 99%

Seronegative Antiphospholipid Syndrome with Anti-phosphatidylethanolamine Antibody in a Boy

et al. 2015

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Antiphospholipid syndrome (APS) is an autoimmune disease caused by antiphospholipid antibodies. At our institution, APS is diagnosed on the basis of the Sapporo criteria, which consist of thrombosis and recurrent pregnancy-related complications and the following laboratory findings: the presence of lupus anticoagulant, anticardiolipin antibody, or anti-β2 glycoprotein 1 antibody. However, we sometimes treat patients we strongly suspect of having APS but who do not satisfy the laboratory criteria. To accommodate such suspected cases, a subtype of APS termed seronegative APS has been proposed. Here, we report on a man with chronic thromobocytopenic purpura since the age of 3 years and multiple cerebral infarctions since the age of 14 years who finally received a diagnosis of seronegative APS with positive antiphosphatidylethanolamine antibodies. (J Nippon Med Sch 2015; 82: 117 120)

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Prevalence and heterogeneity of antiphosphatidylethanolamine antibodies in patients with recurrent early pregnancy losses

Cited by 101 publications

References 39 publications

Vascular Dysfunction in Women with Recurrent Pregnancy Loss

Vascular Dysfunction in Women with Recurrent Pregnancy Loss

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

Seronegative Antiphospholipid Syndrome with Anti-phosphatidylethanolamine Antibody in a Boy

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