Prevalence and Imaging Characteristics of Nonmyelopathic and Myelopathic Spondylotic Cervical Cord Compression

Kovaľová, Ivana; Keřkovský, Miloš; Kadaňka, Zdeněk; Němec, Martin; Jurová, Barbora; Dušek, Ladislav; Jarkovský, Jiří; Bednařík, Josef

doi:10.1097/brs.0000000000001842

Cited by 95 publications

(113 citation statements)

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“…We addressed the issue of an optimal quantitative imaging criterion for cervical cord compression in a recent cross‐sectional study of a large cohort of randomly recruited individuals (Kovalova et al., 2016). We used the same qualitative criterion (a change in spinal cord contour) as a gold standard and validated several quantitative MRI parameters for their sensitivity and specificity to discriminate between nonmyelopathic compression and no compression.…”

Section: Discussionmentioning

confidence: 99%

“…We used the same qualitative criterion (a change in spinal cord contour) as a gold standard and validated several quantitative MRI parameters for their sensitivity and specificity to discriminate between nonmyelopathic compression and no compression. An anteroposterior diameter of the cervical spinal canal of <9.9 mm was associated with the highest probability of MRI‐detected nonmyelopathic cervical cord compression in comparison with CR or CSA, which represent more severe circular compressions and are, on the contrary, more valuable in discrimination between nonmyelopathic compression and symptomatic DCM (Kovalova et al., 2016). We, thus, believe that the use of subjective evaluation of a change in the spinal cord contour or shape compared to that of the neighboring segment and based on agreement of two neuro‐radiologist is a legitimate criterion for definition of MRI signs of degenerative cervical cord compression in this study.…”

Section: Discussionmentioning

confidence: 99%

“…We addressed the issue of an optimal quantitative imaging criterion for cervical cord compression in a recent cross-sectional study of a large cohort of randomly recruited individuals (Kovalova et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The study sample here consisted of a cohort of consecutive subjects who had been referred to the Department of Neurology between January 2012 and December 2013 with clinical signs and symptoms of cervical radiculopathy, moderate‐to‐severe chronic or intermittent axial cervical pain, and volunteers in whom MRI signs of degenerative cervical cord compression had previously been detected during an epidemiological study focusing on the prevalence of degenerative cervical cord compression in the population of the province of South Moravia (Kovalova et al., 2016). The inclusion of volunteers from the epidemiological study, complying with the criteria for the current study into prospective evaluation, had been planned beforehand.…”

Section: Methodsmentioning

confidence: 99%

“…There is a considerable body of current research related to various aspects of DCM, including prognostic factors (Tetreault, Karpova, & Fehlings, 2015;Tetreault, Nouri, Singh, Fawcett, & Fehlings, 2014). In recent years, studies have demonstrated that asymptomatic degenerative cervical cord compression detected on MRI (Boden et al, 1990;Matsumoto et al, 1998;Teresi et al, 1987) may be of a prevalence that exceeds that of symptomatic myelopathy (Bednarik et al, 2004(Bednarik et al, , 2008Bednařík et al, 1998;Kovalova et al, 2016;Wilson et al, 2013). Knowledge of the prevalence, as well as the frequency, of myelopathy development, and of risk factors influencing this progression, however, is sparse (Wilson et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

et al. 2017

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ObjectivesTo update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC).Material and MethodsA prospective observational follow‐up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59 years, range 40–79 years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow‐up of at least 2 years (median duration 3 years). Development of clinical signs of degenerative cervical myelopathy (DCM) as the main outcome was monitored and correlated with a large number of demographic, clinical, electrophysiological, and MRI parameters including diffusion tensor imaging characteristics (DTI) established at entry.ResultsClinical evidence of the first signs and symptoms of DCM were found in 15 patients (13.4%). Development of DCM was associated with several parameters, including the clinical (radiculopathy, prolonged gait and run‐time), electrophysiological (SEP, MEP and EMG signs of cervical cord dysfunction), and MRI (anteroposterior diameter of the cervical cord and cervical canal, cross‐sectional area, compression ratio, type of compression, T2 hyperintensity). DTI parameters showed no significant predictive power. Multivariate analysis showed that radiculopathy, cross‐sectional area (CSA) ≤ 70.1 mm2, and compression ratio (CR) ≤ 0.4 were the only independent significant predictors for progression into symptomatic myelopathy.ConclusionsIn addition to previously described independent predictors of DCM development (radiculopathy and electrophysiological dysfunction of cervical cord), MRI parameters, namely CSA and CR, should also be considered as significant predictors for development of DCM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

et al. 2017

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Predictive Value of the Diffusion Magnetic Resonance Imaging Technique for the Postoperative Outcome of Cervical Spondylotic Myelopathy

Wen

Zhang

et al. 2023

Magnetic Resonance Imaging

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BackgroundDiffusion magnetic resonsance imaging (dMRI) can potentially predict the postoperative outcome of cervical spondylotic myelopathy (CSM).PurposeTo explore preoperative dMRI parameters to predict the postoperative outcome of CSM through multifactor correlation analysis.Study TypeProspective.PopulationPost‐surgery CSM patients; 102 total, 73 male (52.42 ± 10.60 years old) and 29 female (52.0 ± 11.45 years old).Field Strength/Sequence3.0 T/Turbo spin echo T1/T2‐weighted, T2*‐weighted multiecho gradient echo and dMRI.AssessmentSpinal cord function was evaluated using modified Japanese Orthopedic Association (mJOA) scoring at different time points: preoperative and 3, 6, and 12 months postoperative. Single‐factor correlation and t test analyses were conducted based on fractional anisotropy (FA), mean diffusivity, intracellular volume fraction, isotropic volume fraction, orientation division index, increased signal intensity, compression ratio, age, sex, symptom duration and operation method, and multicollinearity was calculated. The linear quantile mixed model (LQMM) and the linear mixed‐effects regression model (LMER) were used for multifactor correlation analysis using the combinations of the above variables.Statistical TestsDistance correlation, Pearson's correlation, multiscale graph correlation and t tests were used for the single‐factor correlation analyses. The variance inflation factor (VIF) was used to calculate multicollinearity. LQMM and LMER were used for multifactor correlation analyses. P < 0.05 was considered statistically significant.ResultsThe single‐factor correlation between all variables and the postoperative mJOA score was weak (all r < 0.3). The linear relationship was stronger than the nonlinear relationship, and there was no significant multicollinearity (VIF = 1.10–1.94). FA values in the LQMM and LMER models had a significant positive correlation with the mJOA score (r = 5.27–6.04), which was stronger than the other variables.Data ConclusionThe FA value based on dMRI significantly positively correlated with CSM patient postoperative outcomes, helping to predict the surgical outcome and formulate a treatment plan before surgery.Evidence Level1Technical EfficacyStage 2

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Cervical Myelopathy

Afifi

Zektser

Raghunandan

2022

A Case-Based Approach to Neck Pain

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Prevalence and Imaging Characteristics of Nonmyelopathic and Myelopathic Spondylotic Cervical Cord Compression

Abstract: 2.

Cited by 95 publications

References 13 publications

Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

Predictive Value of the Diffusion Magnetic Resonance Imaging Technique for the Postoperative Outcome of Cervical Spondylotic Myelopathy

Cervical Myelopathy

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