Prevalence and Impact of Hepatic Steatosis on the Response to Antiviral Therapy in Saudi Patients with Genotypes 1 and 4 Chronic Hepatitis C

AlQaraawi, Abdallah M.; Sanai, Faisal M.; Al-Husseini, Hussa; Albenmousa, Ali; Alsheikh, Abdulmalik; Ahmed, Lubna Rizwan; Hersi, Ahmad; Al-Otaibi, M; Syed, Mohammed Iqbal; Ali, Syed Qaseem; Al–Hamoudi, Waleed; Alswat, Khalid; Abdo, Ayman A.

doi:10.1007/s10620-010-1417-9

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…However, this rate of disease progression changes over time in women as postmenopausal women have increased rates of fibrosis compared with women of reproductive age because they have lost the protective effects of estrogen. Another study, which is consistent with our results, showed that steatosis associated with chronic hepatitis C was disproportionally more frequent in females 34 .…”

Section: Discussionsupporting

confidence: 93%

Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C

et al. 2017

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Background & Aim Several factors involved in the development of liver fibrosis in African American patients with chronic hepatitis C (CHC) have not been well-studied. We aimed to evaluate some of these risk factors. Methods We reviewed pathology and medical records of 603 African Americans with chronic hepatitis C virus (HCV) infection at Howard University Hospital from Jan. 2004 to Dec. 2013. Among the clinical and pathological data collected were HIV (human immunodeficiency virus), HCV genotype, Hepatitis B virus (HBV), diabetes mellitus (DM), hypertension (HTN), body mass index (BMI), and hepatic steatosis. Results The frequency of DM, HTN, HIV and HBV were 22%, 16%, 11%, and 4%, respectively. Median BMI was 27.3 kg/m2. The frequency of fibrosis stages 0, 1, 2, 3 and 4 were 2%, 48%, 28%, 11% and 11%, respectively. In multivariate logistic regression, we found a significant association between liver fibrosis stage (3–4 vs. 0–2) and HIV infection (OR=2.4, P = 0.026), hypertension (OR=3.0, P = 0.001), age (OR=2.6 for every 10 years, P<0.001), weight (OR = 1.1 for every 10 pound increase, P = 0.002) and steatosis grade (OR = 1.6, P = 0.002). The frequency of liver steatosis was 73%. In an ordinal logistic regression, significant risk factors for steatosis were female gender (OR = 1.5, P = 0.034) and inflammation grade (P=0.001). Conclusion This study shows that steatosis is independently associated with fibrosis in African American patients with HCV infection. Female patients were at higher risk for steatosis.

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Section: Discussionsupporting

confidence: 93%

Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C

et al. 2017

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“…In some studies, low baseline GGT level was shown to be an independent predictor of a SVR 9-11,13,15,17. However, these studies did not fully evaluate other confounding factors, such as the presence of hepatosteatosis,19,21,22 bile duct injury,19,23 the degree of liver fibrosis,11,20 alcohol abuse,18,24 and gender,17 which might affect both GGT levels and SVR rates.…”

Section: Introductionmentioning

confidence: 99%

A Lower Serum Gamma-Glutamyltransferase Level Does Not Predict a Sustained Virological Response in Patients with Chronic Hepatitis C Genotype 1

Güzelbulut¹,

Sezıklı²,

Çetinkaya³

et al. 2013

Gut Liver

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Background/AimsLow gamma-glutamyltransferase (GGT) level was shown to be an independent predictor of a sustained virological response (SVR) in chronic hepatitis C. We aimed to determine factors associated with high GGT level, and to evaluate whether low GGT level is an independent predictor of a SVR in chronic hepatitis C genotype 1.MethodsWe retrospectively reviewed our data of patients with chronic hepatitis C genotype 1 treated with pegylated interferon-α and ribavirin. Baseline features were compared between patients with normal and high GGT levels. Factors associated with high GGT level and those associated with a SVR were determined by univariate and multivariate analysis.ResultsThis study included 57 patients. Mean age was 52.28±9.35 years. GGT levels was elevated in 27 patients (47.4%). GGT levels were normal in 63.3% of the patients who achieved a SVR and in 40.7% of those who did not achieve a SVR (p>0.05). By multivariate logistic regression analysis, the presence of cirrhosis (odds ratio [OR], 9.41; 95% confidence interval [CI], 1.08 to 102.61) and female gender (OR, 6.77; 95% CI, 1.23 to 37.20) were significantly associated with high GGT level, and only rapid virological response was associated with a SVR (OR, 8.369; 95% CI, 1.82 to 38.48).ConclusionsLow GGT level does not predict a SVR; however, it may be a predictor of high fibrosis scores.

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“…It is worth noting that some of the findings of Ziada et al have been reported by previous studies in other genotypes and in HCV-4-infected patients as well. The prevalence of steatosis in HCV-4-infected patients has been documented in a few previous studies reporting a prevalence of approximately 40% (3)(4)(5). In the study by AlQaraawi et al (3), for example, 43% of patients showed mild, 42% moderate and 15% severe steatosis (3).…”

mentioning

confidence: 91%

“…The prevalence of steatosis in HCV-4-infected patients has been documented in a few previous studies reporting a prevalence of approximately 40% (3)(4)(5). In the study by AlQaraawi et al (3), for example, 43% of patients showed mild, 42% moderate and 15% severe steatosis (3). These numbers are generally similar to what has been reported in HCV genotype 1 patients.…”

mentioning

confidence: 91%

“…However, the study by Ziada et al is probably the first to clearly examine IR markers as well as effects on antiviral treatment response in an integrated manner rather than just steatosis prevalence in pateints with HCV-4. Previous studies involving HCV-4 patients have shown that variables such as age, gamma-glutamyl transferase levels, platelet count, body mass index, liver fibrosis stage, HOMA-IR, serum lipids and extent of hepatic inflammation are associated with steatosis grade or score (1)(2)(3)(4)(5). The presence of liver steatosis was also reported to be associated with a decreased chance of achieving SVR in two previous studies (3,6).…”

mentioning

confidence: 92%

See 1 more Smart Citation

Hepatitis C, Insulin Resistance and Fatty Liver: Bad Things Come in Threes

Abdo

Lee

2012

Canadian Journal of Gastroenterology

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Prevalence and Impact of Hepatic Steatosis on the Response to Antiviral Therapy in Saudi Patients with Genotypes 1 and 4 Chronic Hepatitis C

Cited by 9 publications

References 16 publications

Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C

Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C

A Lower Serum Gamma-Glutamyltransferase Level Does Not Predict a Sustained Virological Response in Patients with Chronic Hepatitis C Genotype 1

Hepatitis C, Insulin Resistance and Fatty Liver: Bad Things Come in Threes

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