Prevalence and impact of hyperglycemia on hospitalized leukemia patients

Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia

“…Independent of a diagnosis of diabetes, hyperglycemia has been shown to impact the health outcomes of patients with cancer (39, 40). For example, patients with AML who experienced hyperglycemia were found to have a greater risk for infection, (19, 41), sepsis, (42), longer hospital length of stay (18) and mortality. However, inconsistencies in definitions and measurement practices between studies make it difficult to interpret the full impact of hyperglycemia on health outcomes(43).…”

Measurement of Hyperglycemia and Impact on Health Outcomes in People With Cancer: Challenges and Opportunities

“…The occurrence of hyperglycemia among people with cancer was reported (as percent of patients above the established threshold) in seven of the twenty-nine (24%) studies (Ali et al, 2007; Hammer et al, 2009; Luo, Chen, & Chang, 2012; Rentschler et al, 2010; (Matias, Lima, Teixeira, Souto, & Magalhães, 2013; Storey & Von Ah, 2015; Weiser et al, 2004). Only one study reported a calculation of prevalence and provided the formula (Hardy, Nowacki, Bertin, & Weil, 2010).…”

“…The majority of the studies 17/30 (56%) used thresholds ranging between 99 mg/dL to < 126 mg/dL (Ali et al, 2007; Barba et al, 2012; Derr et al, 2009; Derr, Hsiao, & Sauder, 2008; Garg, Bhutani, Alyea, E. &Pendergrass, M., 2007; Flood et al, 2007; Fuji et al, 2007; Fuji et al, 2009; Gebremedhin, Behrendt, Nakamura, Parker, & Salehian, 2013; Hammer et al, 2016; Ito et al, 2014; Luo, Chen, & Chang, 2012; Matias et al, 2013; Storey & Von Ah, 2015; Storey & Von Ah, 2016; Tieu et al, 2015; Wright et al, 2013). …”

“…In patients with cancer, hyperglycemia occurs frequently independent of the diagnosis of diabetes (Farrokhi, Smiley, & Umpierrez, 2011). Researchers have noted the prevalence of hyperglycemia to range from 39% -99% among patients with various types of cancer (Hammer et al, 2009; Sotrey& Von Ah, 2015; Karnchanasorn, Malamug, Jin, Karanes, & Chiu, 2012). …”

“…Harmful consequences from hyperglycemia have also been noted among patients with cancer (Storey & Von Ah, 2012; Storey & Von Ah, 2015). In pre-clinical and clinical studies, the presence of hyperglycemia has been shown to increase the risk of development and progression of cancer, impact diagnostic imaging studies, attenuate the immune system and increase resistance to chemotherapy (Adham et al, 2014; Biernacka et al, 2013; Germenis & Karanikas, 2007; Harris et al, 2013; Kellenberger et al, 2010; Rabkin, Israel, & Keidar, 2010).…”