Prevalence and impact of severe fatigue in adolescent and young adult cancer patients in comparison with population-based controls

Poort, Hanneke; Kaal, Suzanne E. J.; Knoop, Hans; Jansen, R.; Prins, Judith B.; Manten-Horst, Eveliene; Servaes, Petra; Husson, Olga; Graaf, Winette T.A. van der

doi:10.1007/s00520-017-3746-0

Cited by 38 publications

(44 citation statements)

References 31 publications

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Section: Resultsmentioning

confidence: 99%

“…Poort et al examined the association between FCR and fatigue severity by the Cancer Worry Scale and Checklist Individual Strength (CIS‐fatigue). Findings revealed that higher FCR was moderately correlated with fatigue severity . Studies also found that FCR may lead to decreased breast self‐examination frequency and less nicotine dependence .…”

Section: Resultsmentioning

confidence: 99%

“…Strong evidence has been found to support the relationship between high FCR and low QoL. 26,33,43 41 Studies also found that FCR may lead to decreased breast self-examination frequency 32 and less nicotine dependence. 40 Compared with younger adolescents (aged 12-15), older adolescents (aged [16][17][18] are less likely to perform breast self-examination because of general fear about cancer and FCR.…”

Section: Consequences Of Fcrmentioning

confidence: 99%

“…Eleven articles reported information about consequences of FCR. 26,30,[32][33][34]36,[38][39][40][41]43 A study 31 found that FCR was the foremost intense life change the AYA survivors had experienced. Strong evidence has been found to support the relationship between high FCR and low QoL.…”

Section: Consequences Of Fcrmentioning

confidence: 99%

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Fear of cancer recurrence in adolescent and young adult cancer survivors: A systematic review of the literature

Yang

Li²,

Wen

et al. 2019

Psycho-Oncology

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Objective The current systematic review aims to provide an overview of fear of cancer recurrence (FCR) in adolescent and young adult cancer survivors (15‐39 years at cancer diagnosis, AYAs). Methods MEDLINE, PubMed, PsycINFO, and Embase databases were independently searched to identify relevant quantitative articles. PRISMA systematic review procedures were followed with quality assessment. Results Seventeen studies were included in the current review. All were quantitative studies that utilized a cross‐sectional study design. Seven articles reported results of FCR prevalence, six studied determinants related to FCR, and 11 articles provided information about consequences of FCR. Prevalence of FCR ranged from 31% to 85.2% among AYA survivors. Associations between sociodemographic/clinical variables and FCR were inconsistent. Psychological distress and higher treatment intensity were positively associated with higher FCR levels. Lower scores on levels of physical, psychological functioning, and overall health‐related quality of life (QoL) were identified as consequences of increased FCR. Conclusion FCR appears to be a prevalent concern among adolescent and young adult cancer populations. Adequate assessment to determine need for support and intervention is still required. Longitudinal studies in AYAs are warranted to understand the development and potential influence of FCR. Age‐appropriate and flexible psychological care would be more successful potentially with this crucial background information.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Consequences Of Fcrmentioning

confidence: 99%

Section: Consequences Of Fcrmentioning

confidence: 99%

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Fear of cancer recurrence in adolescent and young adult cancer survivors: A systematic review of the literature

Yang

Li²,

Wen

et al. 2019

Psycho-Oncology

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“…Their cancer diagnoses and treatments significantly disrupt their developmental trajectories and construction of personal identity in crucial areas such as education, career, and social relationships. [2][3][4][5] After treatment, they face multifaceted survivorship issues including fatigue, 6,7 psychosocial problems, 8 and practical financial concerns [9][10][11] that can greatly impede their transition back to work or school. 12 A growing body of literature has elucidated AYA cancer survivors' diverse needs.…”

Section: Introductionmentioning

confidence: 99%

Optimizing Survivorship Care Services for Asian Adolescent and Young Adult Cancer Survivors: A Qualitative Study

Tan

et al. 2020

Journal of Adolescent and Young Adult Oncology

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Purpose: With an increasing focus on developing survivorship services tailored for adolescent and young adult (AYA) cancer survivors, incorporation of viewpoints from both survivors and health care professionals (HCPs) is important. This study aims to explore the perceptions of current and prospective survivorship services from both groups in Singapore to propose service design and delivery strategies. Methods: Focus group discussions with 23 AYA cancer survivors between the ages of 16 and 39 years at diagnosis and 18 HCPs were conducted in National Cancer Centre Singapore (NCCS) and Singapore Cancer Society (SCS). All focus group discussions were transcribed verbatim. Deductive thematic analysis was performed according to the components of a design thinking model: empathizing with AYA survivors, defining care gaps, proposing services, and implementation strategies. Results: AYA survivors preferred age-specific services that are aligned with their personal goals. Current survivorship care failed to address the needs of survivors' dependents (caregivers and children) and to consider the utility of each service temporally. Prospective services should clarify disease disclosure obligation in job search and introduce a care navigator. Key implementation strategies included (1) training HCPs on communication techniques with AYA, (2) selecting engagement platforms that complement survivors' informationseeking behavior, (3) improving outreach to survivors through appropriate branding and publicity, and (4) consolidating services from multiple providers. Conclusions: The design of survivorship care services for AYA survivors should be systematic in its conceptualization process and employ implementation strategies. The coordination of the wide spectrum of services warrants a concerted effort by cancer centers, community partners, and the government.

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Specialty Palliative Care and Symptom Severity and Control in Adolescents and Young Adults With Cancer

Gupta,

Li,

Kassam

et al. 2023

JAMA Netw Open

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ImportanceAdolescents and young adults (AYAs) with cancer experience substantial symptom burden. Specialty palliative care (SPC) is recommended but often not involved or involved late.ObjectivesTo determine whether patient-reported symptom severity was associated with subsequent SPC involvement and whether SPC was associated with symptom improvement in AYAs with cancer.Design, Setting, and ParticipantsThis cohort study comprised AYAs (aged 15-29 years) with primary cancer diagnosed between January 1, 2010, and June 30, 2018, in Ontario, Canada. Data, including self-reported Edmonton Symptom Assessment System (ESAS) scores, were obtained from health care databases. Specialty palliative care was identified through billing codes and validated algorithms. Final data analysis was performed on April 4, 2023.Main Outcomes and MeasuresAssociations of ESAS scores with subsequent SPC involvement were determined. A difference-in-differences approach was used for patients who died within 5 years of their cancer diagnosis. Case patients (SPC predeath, index date equals first SPC service) were matched 1:1 to control patients (no SPC at equivalent time before death). The study examined whether the difference between 90-day postindex and preindex mean ESAS scores was itself different between case and control patients.ResultsThis study included 5435 AYAs with cancer, with a median follow-up of 5.1 (IQR, 2.5-7.9) years for analyses of general palliative care. Their median age at cancer diagnosis was 25 (IQR, 22-27) years, and more than half were male (2809 [51.7%]). For all symptoms, moderate and severe ESAS scores were associated with an increased likelihood of SPC involvement compared with mild scores. The greatest magnitude of association was seen for pain scores (hazard ratio for severe vs mild, 7.7 [95% CI, 5.8-10.2]; P &lt; .001). A total of 721 AYAs (13.3%) died within 5 years of diagnosis, and 612 of these patients (84.9%) had received SPC before death. Among 202 case-control pairs, SPC involvement was associated with improved pain trajectories (mean scores improved from 3.41 to 3.07 in case patients and worsened from 1.86 to 2.16 in control patients; P = .003). Other symptom trajectories were not affected.Conclusions and RelevanceIn this cohort study of AYAs with cancer, those reporting moderate or severe symptoms through a screening program were more likely to subsequently receive SPC. These findings suggest that SPC was associated with a subsequent decrease in pain severity but did not affect other symptoms. New interventions targeting other symptoms during treatment and particularly at the end of life are needed.

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Prevalence and impact of severe fatigue in adolescent and young adult cancer patients in comparison with population-based controls

Cited by 38 publications

References 31 publications

Fear of cancer recurrence in adolescent and young adult cancer survivors: A systematic review of the literature

Fear of cancer recurrence in adolescent and young adult cancer survivors: A systematic review of the literature

Optimizing Survivorship Care Services for Asian Adolescent and Young Adult Cancer Survivors: A Qualitative Study

Specialty Palliative Care and Symptom Severity and Control in Adolescents and Young Adults With Cancer

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