Prevalence and Impact of Upper Gastrointestinal Symptoms in The Canadian Population: Findings From The Digest Study

Tougas, Gervais; Chen, Yu Chang; Hwang, Peggy; Liu, Miaomiao; Eggleston, Andrew

doi:10.1111/j.1572-0241.1999.01427.x

Cited by 114 publications

(72 citation statements)

References 27 publications

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“…In this study coffee or tea intake has not been shown to be related to the presence of Dyspepsia similarly studied in rural Asia [57]. In addition, some western studies have reported that excessive coffee or tea intake has not been shown to be related to the presence of Dyspepsia [58,59].…”

Section: Discussionmentioning

confidence: 81%

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Ayele¹,

Molla²

2017

Clin Microbiol

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Dyspepsia is a common symptom of gastrointestinal disease with global distribution. The prevalence of this disorder varies between 3% and 40%. Dyspeptic symptoms account 10% of hospital admissions in Ethiopia. The aim of this study was to determine the contributing factors for dyspepsia at Yirga cheffe primary hospital, Southern Ethiopia.: A case control study design was conducted between July 6, 2016 and August 10, 2016 on a total of 168 patients at Yirga cheffe primary hospital, South Ethiopia. The Helicobacter pylori (H. pylori) stool antigen test was used to analyze the stool samples and a face to face interview was taken to assess other contributing factors for the infection. Ethical clearance and informed consents was obtained before data collection. Logistic regression analysis was used to estimate odds ratio (adjusted with 95% confidence interval) of positive responses to the different risk factors. Comparisons between groups were assessed with chi-square test and a P-value of <0.05 was considered statistically significant. Helicobacter pylori antigen was detected in 13 of the 168. Helicobacter pylori infection was six times more associated with dyspeptic patients than non-Dyspeptic individuals. Anxiety and depression was six and three times more likely associated with dyspepsia, respectively. Although dyspepsia was greater among male, and peaked in the age groups of 21-30 years old, the association was not statistically significant. Moreover, patients who consume foods containing peppercorn ("key wot") have high chance of developing Dyspepsia. Study subjects who depend on untapped drinking water sources, treating their drinking water, smoking habit, chewing khat, washing their hand with soap, and their toilet with flush tank were not significantly associated with dyspepsia (P>0.05). Thus, early diagnosis of H. pylori, psychological treatment of patients and food habit of the individuals should give attention to prevent and control Dyspepsia even though additional studies need to be conducted.

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Section: Discussionmentioning

confidence: 81%

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Ayele¹,

Molla²

2017

Clin Microbiol

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“…QOL in patients with RE is lower than that in patients with heart failure (mild) and angina pectoris [20]. It is known that QOL in patients with FD is also decreased [1,2] and may be as low as patients with RE due to upper abdominal symptoms. Once symptoms are relieved by PPI treatment, improvement of QOL in patients with upper abdominal symptoms is expected.…”

Section: Discussionmentioning

confidence: 99%

“…In the majority of patients, symptoms are mild and can be controlled by over-the-counter drugs. The rest of the patients visiting hospitals have severer symptoms and decreased quality of life (QOL) [1,2], but their symptoms are not always treated satisfactorily. Patients usually have variety of symptoms and it sometimes makes physicians felt difficulty to select adequate treatment unless the symptoms are clearly accounted to organic disease, leaving patients in an undesirable condition.…”

Section: Introductionmentioning

confidence: 99%

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Adachi

Matsumori

Fujisawa

et al. 2006

J. Clin. Biochem. Nutr.

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Summary Objective: A number of clinical trials have reported that proton-pump inhibitors are efficacious in the treatment of upper abdominal symptoms, but most of these trials have been carried out in Caucasians. This study investigated the type of upper abdominal symptoms reported by Japanese patients with reflux esophagitis and the efficacy of omeprazole for treating their symptoms.Methods: A total of 234 patients aged ≥20 years with grade A to D reflux esophagitis were enrolled in this multicenter, open study. Patients received omeprazole 10 or 20 mg/day for 4 weeks. Symptom and quality of life questionnaires were administered at baseline, week 2 and week 4.Results: Among the 221 evaluable patients, almost 70% reported reflux-type symptoms (e.g. regurgitation and heartburn). Ulcer-and dysmotility-type symptoms (e.g. stomach pain and belching) were also common, occurring in 38-62% of patients. After 4 weeks of omeprazole *To whom correspondence should be addressed. Tel: +81-853-20-2190 Fax: +81-853-20-2187 E-mail: kadachi@med.shimane-u.ac.jp Abbreviations: ARD, acid-related disease; FD, functional dyspepsia; GSRS, Gastrointestinal Symptoms Rating Scale; PPIs, proton pump inhibitors; PU, peptic ulcer; QOL,quality of life; RE, reflux esophagitis; SD, standard deviation. Conclusion: Reflux-type symptoms as well as ulcer-and dysmotility-type symptoms were seen frequently in Japanese patients with reflux esophagitis. However, omeprazole improved all symptom types and quality of life in this patient population.

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“…8 Both in the general population and in tertiary care, the most prevalent symptoms are postprandial fullness, epigastric pain, early satiety, and nausea. [9][10][11][12][13] However, there is considerable heterogeneity in the symptom pattern, both in number and type of symptoms. 14 …”

Section: 5-7mentioning

confidence: 99%

Pathophysiology and Treatment of Functional Dyspepsia

Tack

Lee

2005

Journal of Clinical Gastroenterology

208

247

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Functional dyspepsia is a highly prevalent symptom complex and a heterogenous disorder. Recent studies showed potential associations between specific pathophysiologic disturbances and dyspeptic symptoms. Delayed gastric emptying reported in about 30% of patients with functional dyspepsia is associated with the symptoms of postprandial fullness, nausea, and vomiting. Impaired gastric accommodation present in 40% of functional dyspepsia patients is found to be associated with early satiety. Hypersensitivity to gastric distension is observed in 37% of functional dyspepsia patients and associated with the symptoms of postprandial pain, belching, and weight loss. Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms. Therapeutic options are still limited but targeted therapy directed at the underlying pathophysiology seems desirable. Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required.

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Prevalence and Impact of Upper Gastrointestinal Symptoms in The Canadian Population: Findings From The Digest Study

Cited by 114 publications

References 27 publications

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Pathophysiology and Treatment of Functional Dyspepsia

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