Prevalence and Incidence of Atopic Dermatitis: A Systematic Review

Abstract

This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta Acta Derm Venereol 2020; 100: adv00160 Centenary theme section: ATOPIC DERMATITIS SIGNIFICANCEAtopic dermatitis is common, and is often burdensome for the individual. An overview of how often AD occurs is therefore necessary. A systematic review was performed, which included more than 7,000 articles with data from all continents, on children and adults. Each year, up to 17.1% of adults and 22.6% of children were diagnosed with AD; with as many as 9.6% new cases of AD in children. Surprisingly, in adults, studies on new cases were from the 20 th century. The results will be useful for patient organizations, physicians, scientists and healthcare planning, especially as new therapies are emerging.The primary objective of this study was to systematically review and analyse epidemiological studies of the prevalence and incidence of atopic dermatitis (AD) during childhood and adulthood, focusing on data from the 21 st century. A systematic search of PubMed, EMBASE and Google (manual search) was performed in June 2019, followed by data abstraction and study quality assessment (Newcastle-Ottawa Scale). Cross-sectional and longitudinal epidemiological studies of individuals with AD (doctor-diagnosed or standardized definition) were included. Of 7,207 references reviewed, 378 moderate/good-quality studies were included: 352 on prevalence of AD and 26 on incidence of AD. In the 21 st century, the 1-year prevalence of doctor-diagnosed AD ranged from 1.2% in Asia to 17.1% in Europe in adults, and 0.96% to 22.6% in children in Asia. The 1-year incidence ranged from 10.2 (95% confidence interval (95% CI) 9.9-10.6) in Italy to 95.6 (95% CI 93.4-97.9) per 1,000 person-years in children in Scotland. There were few recent studies on incidence of AD in the 21 st century and no studies on adults only; most studies were conducted in Europe and the USA. Epidemiological studies on childhood and adulthood AD in different continents are still needed, especially on the incidence of AD during adulthood.

Strategies for Selecting Therapeutic Tactics for Reducing Transcutaneous Sensibilisation Risk in Infants with Atopic Dermatitis: Cohort Retrospective Prospective Study

“…Атопический дерматит (АтД) представляет собой наиболее распространенное воспалительное заболевание кожи у детей, характеризующееся хроническим рецидивирующим течением и имеющее определенные особенности клинической картины в зависимости от возраста [1]. Различные эпидемиологические исследования и систематические обзоры демонстрируют, что показатель распространенности АтД варьирует от 10 до 30% в детской популяции, при этом наиболее подвержено развитию АтД население промышленно развитых и развивающихся стран, стоит также отметить, что показатель распространенности АтД в мире неуклонно нарастает [2,3,4]. АтД является мультифакторным заболеванием, патогенез которого складывается из взаимодействия множества факторов, как внешних, так и внутренних, на фоне генетической предрасположенности индивидуума, что в конечном итоге приводит к иммунной дисрегуляции, а также к нарушению функции и целостности эпидермального барьера [5].…”

Biological drugs in the treatment of atopic dermatitis – recommendations of the Polish Dermatological Society, the Polish Society of Allergology, the Polish Pediatric Society and the Polish Society of Family Medicine

“…Atopowe zapalenie skóry (AZS) (ICD-10 L20) to choroba przewlekła, która występuje głównie u dzieci (10-20%) i utrzymuje się do wieku dorosłego u ok. 1/5 tej grupy [1]. Częstość występowania AZS u dorosłych oszacowano na 2,1-4,9% [2].…”

Clinical and Economic Burden of Pediatric Mild-to-Moderate Atopic Dermatitis: A Population-Based Nested Case–Control Study in Sweden

“…Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition which manifests as pruritus and eczematous lesions that can be acute, subacute, or chronic [1,2]. Prevalence of AD is high across all continents, and approximately 20% of children and 2-8% of adults are affected in Western countries [2,3]. Prevalence appears to be increasing in Western Europe [2,4] and seems stable in Northern Europe [5].…”