Prevalence and incidence of chronic kidney disease stage G5 in Japan

Yamagata, Kunihiro; Yamada, Takashi; Nakai, Shigeru; Nakayama, Masaaki; Imai, Enyu; Hattori, Motoshi; Iseki, Kunitoshi; Akiba, Takashi

doi:10.1007/s10157-014-0978-x

Cited by 46 publications

(34 citation statements)

References 18 publications

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“…The percent of Americans over 65 years of age is expected to be 20 % by 2050 (Weiner and Tilly 2002), a proportion already reached in Japan, with 24 % older than 65 years (Nitta et al 2013). The prevalence of chronic kidney disease (CKD) in Japan is 13 %, and it has the second highest prevalence of end-stage renal disease (ESRD) in the world (Imai et al 2009;Yamagata et al 2014). CKD is also common in the USA at 11 % (Coresh et al 2007), with the USA ranked third in world for ESRD.…”

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confidence: 99%

Aging and low-grade inflammation reduce renal function in middle-aged and older adults in Japan and the USA

Costello-White

Ryff

Coe

2015

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The objective of this study was to investigate the effects of low-grade inflammation on age-related changes in glomerular filtration rate (GFR) in middleaged and older white Americans, African-Americans, and Japanese adults. Serum creatinine, C-reactive protein (CRP), and interleukin-6 (IL-6) levels were determined for 1570 adult participants in two surveys of aging in the USA and Japan (N = 1188 and 382, respectively). Kidney function declined with age in both countries and was associated with IL-6 and CRP. IL-6 and CRP also influenced the extent of the arithmetic bias when calculating the GFR using the chronic kidney disease epidemiology (CKD-EPI) formula with just serum creatinine. Younger African-Americans initially had the highest GFR but showed a steep age-related decrement that was associated with elevated inflammation. Japanese adults had the lowest average GFR but evinced a large effect of increased inflammatory activity when over 70 years of age. Importantly, our results also indicate that low-grade inflammation is important to consider when evaluating kidney function solely from serum creatinine.

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confidence: 99%

Aging and low-grade inflammation reduce renal function in middle-aged and older adults in Japan and the USA

Costello-White

Ryff

Coe

2015

AGE

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“…Even in more complicated systems such as cardiopulmonary bypass, a combination of negative pressure and air interface had the largest rate of damage. However, considering the long life span of HD patients and low incidence of kidney transplantation in Japan, any injury to red blood cells should be averted (17). In our mock dialysis experiment, hemolysis was dependent on PreAP regardless of needle diameter.…”

Section: Discussionmentioning

confidence: 77%

Re‐evaluation of Pre‐pump Arterial Pressure to Avoid Inadequate Dialysis and Hemolysis: Importance of Prepump Arterial Pressure Monitoring in Hemodialysis Patients

et al. 2015

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Prepump arterial pressure (PreAP) is monitored to avoid generating excessive negative pressure. The National Kidney Foundation K/DOQI clinical practice guidelines for vascular access recommend that PreAP should not fall below -250 mm Hg because excessive negative PreAP can lead to a decrease in the delivery of blood flow, inadequate dialysis, and hemolysis. Nonetheless, these recommendations are consistently disregarded in clinical practice and pressure sensors are often removed from the dialysis circuit. Thus far, delivered blood flow has been reported to decrease at values more negative than -150 mm Hg of PreAP. These values have been analyzed by an ultrasonic flowmeter and not directly measured. Furthermore, no known group has evaluated whether PreAP-induced hemolysis occurs at a particular threshold. Therefore, the aim of this study was to clarify the importance of PreAP in the prediction of inadequate dialysis and hemolysis. By using different diameter needles, human blood samples from healthy volunteers were circulated in a closed dialysis circuit. The relationship between PreAP and delivered blood flow or PreAP and hemolysis was investigated. We also investigated the optimal value for PreAP using several empirical monitoring methods, such as a pressure pillow. Our investigation indicated that PreAP is a critical factor in the determination of delivered blood flow and hemolysis, both of which occured at pressure values more negative than -150 mm Hg. With the exception of direct pressure monitoring, commonly used monitoring methods for PreAP were determined to be ineffective. We propose that the use of a vacuum monitor would permit regular measurement of PreAP.

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“…only patients who underwent dialysis treatment were included, as data were unavailable for patients who did not initiate dialysis or who underwent preemptive kidney transplantation in Japan. However, the number of preemptive kidney transplant patients is small in Japan, with only 101 patients being reported in 2009 [10]. In addition, each registry uses different methods to collect and report data.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to note that only patients who underwent dialysis treatment were included in the JSDT Registry, as data were unavailable for adult patients who did not initiate dialysis or who received a preemptive kidney transplant. Although the number of preemptive kidney transplant patients is still small among the adult Japanese population [10], there has been a marked increase in the use of preemptive kidney transplantation as the initial treatment modality for paediatric RRT [11]. Thus, we also extracted data on incident paediatric ESKD patients in Japan from survey data published by the Japanese Society for Paediatric Nephropathy (JSPN) in 2006-2011 [11], which included patients who did not initiate RRT or who received preemptive kidney transplants.…”

Section: Data Sourcementioning

confidence: 99%

Age- and gender-specific incidence rates of renal replacement therapy in Japan: an international comparison

2016

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Background: Japan has relatively low incidence rates of renal replacement therapy (RRT) for end-stage kidney disease (ESKD) among those aged 0-19 years, but relatively high rates for the older age band. On the other hand, Australia has relatively high rates among those aged 0-19 years, but relatively low rates for the older age band. Thus, an international comparison between Japan and Australia would be informative. This study aimed to compare age-and gender-specific incidence rates of RRT in Japan with the total incidence of ESKD in Australia, which includes both those who start RRT and those who died of ESKD without RRT, in order to better understand the burden of ESKD independently of differences in the acceptance rate of RRT. We also compared incidence rates in Japan with published data from two major registries, the United States Renal Data System (USRDS) and the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA). Methods: Data on numbers of patients who initiated RRT in Japan were extracted from data published by the Japanese Society of Dialysis Therapy (JSDT) Registry in 2003-2007 and 2011. Age-and gender-specific incidence rates were calculated by dividing the number of incident patients for each age-gender category by the total number of people in the corresponding population. Incidence in other countries was extracted from a published paper in Australia, tables in the USRDS annual report 2011, and the ERA-EDTA annual report 2011. Results: Among males aged 50 to 69 years, incidence rates of RRT in Japan were about two times the total incidence of ESKD in Australia. Compared with the incidence rates of RRT reported by the USRDS and the ERA-EDTA, Japanese males have similar or substantially higher rates, respectively. Conclusions: Japan has a higher incidence of RRT among middle-and older-aged populations compared to the total incidence rates of ESKD in Australia. This higher incidence in Japan cannot be explained by differences in the acceptance rate for RRT since data from Australia included both treated and untreated ESKD. A strategy that targets middle-and older-aged males will be necessary to decrease the incidence of RRT in Japan.

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Prevalence and incidence of chronic kidney disease stage G5 in Japan

Cited by 46 publications

References 18 publications

Aging and low-grade inflammation reduce renal function in middle-aged and older adults in Japan and the USA

Aging and low-grade inflammation reduce renal function in middle-aged and older adults in Japan and the USA

Re‐evaluation of Pre‐pump Arterial Pressure to Avoid Inadequate Dialysis and Hemolysis: Importance of Prepump Arterial Pressure Monitoring in Hemodialysis Patients

Age- and gender-specific incidence rates of renal replacement therapy in Japan: an international comparison

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