Prevalence and incidence of complications at diagnosis of T2DM and during follow-up by BMI and ethnicity: a matched case–control analysis

Adjah, Ebenezer S. Owusu; Bellary, Srikanth; Hanif, Wasim; Patel, Kiran; Khunti, Kamlesh; Paul, Sanjoy K.

doi:10.1186/s12933-018-0712-1

Cited by 28 publications

(42 citation statements)

References 32 publications

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“…At diagnosis the rates of comorbidities were 30% in white Europeans compared with 11% of African-Caribbean and South Asian populations [86]. Clear distinctions in the incidence of chronic kidney disease have been found, which is higher in white Europeans than both African-Caribbean and South Asian populations [86]. Ethnic differences in the incidence of major cardiovascular diseases are also apparent; coronary heart disease is highest among South Asians, whereas African-Caribbean people experience significantly lower rates of coronary heart disease compared with white Europeans and South Asians, but rates of stroke do not differ by ethnicity [86,87].…”

Section: Glycaemic Control Diabetes Complications and Mortalitymentioning

confidence: 99%

“…Clear distinctions in the incidence of chronic kidney disease have been found, which is higher in white Europeans than both African-Caribbean and South Asian populations [86]. Ethnic differences in the incidence of major cardiovascular diseases are also apparent; coronary heart disease is highest among South Asians, whereas African-Caribbean people experience significantly lower rates of coronary heart disease compared with white Europeans and South Asians, but rates of stroke do not differ by ethnicity [86,87]. Detailed investigations in the SABRE cohort are providing evidence for the mechanisms which may underlie these ethnic patterns in cardiovascular diseases.…”

Section: Glycaemic Control Diabetes Complications and Mortalitymentioning

confidence: 99%

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Ethnicity and Type 2 diabetes in the UK

Goff

2019

Diabet. Med.

125

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Type 2 diabetes is a major UK public health priority. Among minority ethnic communities, the prevalence is alarmingly high, approximately three to five times higher than in the white British population. Particularly striking is the earlier onset of Type 2 diabetes, which occurs some 10–12 years younger, with a significant proportion of cases being diagnosed before the age of 40 years. This review focuses on the UK context and Type 2 diabetes in adult populations, exploring the available evidence regarding the complex interplay of biological, lifestyle, social, clinical and healthcare system factors that are known to drive these disparities.

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Section: Glycaemic Control Diabetes Complications and Mortalitymentioning

confidence: 99%

Section: Glycaemic Control Diabetes Complications and Mortalitymentioning

confidence: 99%

Ethnicity and Type 2 diabetes in the UK

Goff

2019

Diabet. Med.

125

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“…Previous studies investigating this association have been impeded by the need to use complete record analysis due to missing data in ethnicity, which can create systematic bias in estimates. 33 The use of our approach would help overcome this limitation.…”

Section: Findings In Relation To Other Evidence and Implicationsmentioning

confidence: 99%

<p>Ethnic Differences in the Prevalence of Type 2 Diabetes Diagnoses in the UK: Cross-Sectional Analysis of the Health Improvement Network Primary Care Database</p>

Pham¹,

Carpenter²,

Morris³

et al. 2019

CLEP

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Aims/Hypothesis: Type 2 diabetes mellitus is associated with high levels of disease burden, including increased mortality risk and significant long-term morbidity. The prevalence of diabetes differs substantially among ethnic groups. We examined the prevalence of type 2 diabetes diagnoses in the UK primary care setting. Methods: We analysed data from 404,318 individuals in The Health Improvement Network database, aged 0-99 years and permanently registered with general practices in London. The association between ethnicity and the prevalence of type 2 diabetes diagnoses in 2013 was estimated using a logistic regression model, adjusting for effect of age group, sex, and social deprivation. A multiple imputation approach utilising population-level information about ethnicity from the UK census was used for imputing missing data. Results: Compared with those of White ethnicity (5.04%, 95% CI 4.95 to 5.13), the crude percentage prevalence of type 2 diabetes was higher in the Asian (7.69%, 95% CI 7.46 to 7.92) and Black (5.58%, 95% CI 5.35 to 5.81) ethnic groups, while lower in the Mixed/Other group (3.42%, 95% CI 3.19 to 3.66). After adjusting for differences in age group, sex, and social deprivation, all minority ethnic groups were more likely to have a diagnosis of type 2 diabetes compared with the White group (OR Asian versus White 2.36, 95% CI 2.26 to 2.47; OR Black versus White 1.65, 95% CI 1.56 to 1.73; OR Mixed/Other versus White 1.17, 95% CI 1.08 to 1.27). Conclusion: The prevalence of type 2 diabetes was higher in the Asian and Black ethnic groups, compared with the White group. Accurate estimates of ethnic prevalence of type 2 diabetes based on large datasets are important for facilitating appropriate allocation of public health resources, and for allowing population-level research to be undertaken examining disease trajectories among minority ethnic groups, that might help reduce inequalities.

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“…Sone et al found-in a relatively small cohort study-that a high WC value alone is not sufficient to raise the risk of CVD events significantly and is not an independent risk factor in Japanese diabetic patients [26]. Previous study found that the risk of developing long-term MACE differed in different populations [27]. Few studies have investigated sex differences in the relationship between WC and CVD in Western populations.…”

Section: Introductionmentioning

confidence: 99%

Waist circumference is associated with major adverse cardiovascular events in male but not female patients with type-2 diabetes mellitus

Xing

Peng

Wang

et al. 2020

Cardiovasc Diabetol

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Background: Although studies have shown that waist circumference (WC) is positively associated with an increased risk of cardiovascular diseases among the normal population, few studies have investigated WC in patients with type-2 diabetes mellitus (T2DM). Methods: This was a post hoc analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. The Cox proportional hazards models was used to investigate the relationship between WC and major adverse cardiovascular events (MACEs) in T2DM patients with cardiovascular disease (CVD) or high risk factors of CVD. Results: A total of 10,251 T2DM patients (6299 men [61.4%], 3952 women [38.6%]) were included in our analysis. The mean age was 64.0 ± 7.53 years. After a mean follow-up at 9.2 ± 2.4 years later, 1804 patients (event rate of 23 per 1000 person-years) had developed MACEs. MACEs rates in men and women were 18.0 and 26.0 events per 1000 person-years, respectively. After multivariable adjustment, each increase in WC of 1 SD increased the risk of MACEs (HR: 1.10, 95% CI 1.04-1.17; P < 0.01) in men, with a non-significant increase in MACEs (HR: 1.04, 95% CI 0.95-1.13; P = 0.40) in women. Compared with those in the first quartile of WC, male patients in the fourth quartile of WC had a hazard ratio (HR) of 1.24 (95% CI 1.05-1.46) for MACEs; female patients in the fourth quartile of WC had an HR of 1.22 (95% CI 0.96-1.56) for MACEs. Conclusions: Higher WC is associated with increased risks of MACEs in male but not female T2DM patients.

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Prevalence and incidence of complications at diagnosis of T2DM and during follow-up by BMI and ethnicity: a matched case–control analysis

Cited by 28 publications

References 32 publications

Ethnicity and Type 2 diabetes in the UK

Ethnicity and Type 2 diabetes in the UK

<p>Ethnic Differences in the Prevalence of Type 2 Diabetes Diagnoses in the UK: Cross-Sectional Analysis of the Health Improvement Network Primary Care Database</p>

Waist circumference is associated with major adverse cardiovascular events in male but not female patients with type-2 diabetes mellitus

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