Prevalence and Incidence of Interstitial Cystitis in a Managed Care Population

Clemens, J. Quentin; Meenan, Richard T.; Rosetti, Maureen C. O’Keeffe; Gao, Sara Y.; Calhoun, Elizabeth A.

doi:10.1097/01.ju.0000146114.53828.82

Cited by 188 publications

(117 citation statements)

References 14 publications

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“…In the urological field, it has been well documented that prevalence and incidence of interstitial cystitis, which is a syndrome consisting of severe refractory bladder symptoms such as suprapubic pain, urinary frequency, and urgency without a specific identifiable cause, for women are significantly higher than those for men (10). What pathophysiological factors are involved in these sex-related differences?…”

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confidence: 99%

Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice

Yoshiyama¹,

Kobayashi²,

Araki³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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related differences in lower urinary tract (LUT) activity responding to intravesical infusion of diluted acetic acid (A/A, pH 3.0) were investigated during cystometrograms in decerebrate unanesthetized mice. A/A produced a decrease of intercontraction intervals in both female and male animals, and the extent of the decrease in male mice was much less than in female mice [19 Ϯ 5% (P ϭ 0.03) vs. 65 Ϯ 5% (P ϭ 0.03); n ϭ 6 for each], exhibiting a marked difference between the two groups in response to acid irritation of the LUT (P ϭ 0.002). A/A reduced maximal voiding pressure (MVP) (19 Ϯ 4%, P ϭ 0.03) but had no effect on pressure threshold for inducing voiding contraction (PT) (P ϭ 0.56) in females, whereas A/A did not change MVP (P ϭ 1.00) but increased PT (16 Ϯ 4%, P ϭ 0.03) in males. A/A decreased bladder compliances of female and male mice in a similar fashion (44 Ϯ 10% vs. 24 Ϯ 7%, P ϭ 0.03 for each). In male mice, A/A produced persistent dribbling of fluid after voiding contraction phase, which was virtually not seen in females. The present study demonstrates the differences between female and male mice in response to noxious stimulation in the LUT: the female bladder is more sensitive to the acid irritation, while the male urethra is more irritable to the noxious stimulus. Identification of mechanisms underlying sex-specific characteristics might be helpful for elucidating pathogenesis of painful bladder syndrome. afferent; bladder tonus; detrusor contractility; efferent; urethral resistance NUMEROUS IN VIVO PHYSIOLOGICAL and pharmacological studies examining bladder and urethral activity have been conducted exclusively in one sex of animals in each experimental design, and thus it is uncertain whether functional responses of female and male lower urinary tracts are similar. There are only a few articles detailing differences between females and males in the lower urinary tract functions. Of the available reports, for example, one previous study comparing female and male rats in cystometry revealed that volume thresholds for inducing micturition were changed in accordance with altered intravesical infusion rates in the female rat, whereas these were constant regardless of the bladder filling rates in the male (24). The study suggested the possibility that mechanosensory afferent responses to intensity of the mechanical stimulus were different between the female and male animals.Epidemiologic studies have demonstrated sex-specific differences in prevalence and incidence of certain diseases. In the urological field, it has been well documented that prevalence and incidence of interstitial cystitis, which is a syndrome consisting of severe refractory bladder symptoms such as suprapubic pain, urinary frequency, and urgency without a specific identifiable cause, for women are significantly higher than those for men (10). What pathophysiological factors are involved in these sex-related differences?Here, we proposed the possibilities that sex differences in mechanisms responsible for transmitting inflammatory pai...

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confidence: 99%

Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice

Yoshiyama¹,

Kobayashi²,

Araki³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…CPP affects 15% of both men and women, and commonly involves the pelvic cavity, as in irritable bowel syndrome (IBS) and interstitial cystitis (IC), and/or the pelvic floor (Berger et al 1998;Clemens et al 2005;Mathias et al 1996;Moldwin 2002;Wesselmann 2001;Zondervan et al 2001). Considering that the colorectum and urinary bladder, exclusive from other pelvic organs, function as an integral part of daily, physiological pelvic activity, it is not surprising that IBS and IC, analogous disorders of pelvic visceral pain and urgency, account for half of all cases of CPP (Zondervan et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Convergence of bladder and colon sensory innervation occurs at the primary afferent level

Christianson¹,

Liang²,

Ustinova³

et al. 2007

Pain

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Dichotomizing afferents are individual dorsal root ganglion (DRG) neurons that innervate two distinct structures thereby providing a form of afferent convergence that may be involved in pelvic organ cross-sensitization. To determine the distribution of dichotomizing afferents supplying the distal colon and bladder of the Sprague-Dawley rat and the C57Bl/6 mouse, we performed concurrent retrograde labeling of urinary bladder and distal colon afferents using cholera toxin subunit B (CTB) fluorescent conjugates. Animals were perfused 4-5 days after sub-serosal organ injections, and the T10-S2 DRG were removed, sectioned, and analyzed using confocal microscopy. In the rat, CTBpositive afferents retrogradely labeled from the bladder were nearly 3 times more numerous than those labeled from the distal colon, while in the mouse, each organ was equally represented. In both species, the majority of colon and bladder afferents projected from lumbosacral (LS) ganglia and secondarily from thoracolumbar (TL) ganglia. In the rat, 17% of the total CTB-positive neurons were retrogradely labeled from both organs with 11% localized in TL, 6% in LS, and 0.8% in thoracic (TH) ganglia. In the mouse, 21% of the total CTB-positive neurons were dually-labeled with 12% localized in LS, 4% in TH, and 4% in TL ganglia. These findings support the existence of dichotomizing pelvic afferents, which provide a pre-existing neuronal substrate for possible immediate and maintained pelvic organ cross-sensitization and ultimately may play a role in the overlap of pelvic pain disorders.

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“…IN-DEPTH KNOWLEDGE of bladder sensory transduction is important because a large number of patients have idiopathic chronic hypersensory bladder complaints such as urinary urgency, urge incontinence, frequency, nocturia, and bladder pain (6,27). There are currently two bladder hypersensory syndromes: overactive bladder (OAB) and interstitial cystitis (IC).…”

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confidence: 99%

EGF and HB-EGF modulate inward potassium current in human bladder urothelial cells from normal and interstitial cystitis patients

Sun¹,

Chen²,

Lowentritt³

et al. 2007

American Journal of Physiology-Cell Physiology

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Prevalence and Incidence of Interstitial Cystitis in a Managed Care Population

Abstract: The prevalence and incidence of interstitial cystitis is significantly higher for women and men than previously published estimates. Men account for a higher proportion of patients with IC than has previously been recognized.

Cited by 188 publications

References 14 publications

Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice

Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice

Convergence of bladder and colon sensory innervation occurs at the primary afferent level

EGF and HB-EGF modulate inward potassium current in human bladder urothelial cells from normal and interstitial cystitis patients

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