Prevalence and incidence of major depressive disorders among people living with HIV residing in Africa: a systematic review and meta-analysis protocol

Abstract

BackgroundDepression represents one of the most frequent neuro-psychiatric diseases; it seems to be more prevalent in people living with HIV compared to the general population. However, summarized data in the African setting on the topic are scarce. This systematic review and meta-analysis aims at assessing the prevalence and incidence of major depressive disorders (MDD) in HIV-infected African populations residing in Africa.Methods and designThis review will include observational studies conducted among HIV-infected people residing in Africa, which have reported either the prevalence or incidence of MDD or enough data for its appraisal. Relevant records will be searched using PubMed/Medline, EMBASE, African Journals Online, and Africa Index Medicus. In addition, reference lists of eligible papers and relevant review articles will be screened. Published studies from inception Jan 1, 2000 to Dec 31, 2017 will be considered regardless of language of publication. Two review authors will independently screen, select studies, and extract data, with discrepancies resolved by consensus or arbitration by a third review author. Methodological quality of included studies will be assessed using the scale developed by Hoy and colleagues. Funnel-plots and Egger’s test will be used to determine publication bias. The study-specific estimates will be pooled through a random-effects meta-analysis model to obtain an overall summary estimate. The heterogeneity will be evaluated by the χ2 test on Cochrane’s Q statistic. Results will be presented by geographical region and antiretroviral therapy status.DiscussionThis study is based on published data; therefore, ethical approval is not a requirement. The final report of this study in the form of a scientific paper will be published in a peer-reviewed journal and presented at scientific conferences. This review will help to have an overview of the burden of MDD among HIV-infected people residing in Africa.Systematic review registrationPROSPERO, CRD42017058118.Electronic supplementary materialThe online version of this article (10.1186/s13643-018-0672-2) contains supplementary material, which is available to authorized users.

In utero antiretroviral exposure and sociodemographic characteristics on neurodevelopment of HIV‐exposed uninfected children versus HIV‐unexposed uninfected healthy children in Malawi

“…HIV infection is one of the major global public health concerns, having affected more than 35 million lives since the beginning of the global epidemic 1 . southern Africa is the region worst affected by HIV in the world and accounts for one‐third of the global HIV burden 2 .…”

“…HIV infection is one of the major global public health concerns, having affected more than 35 million lives since the beginning of the global epidemic. 1 southern Africa is the region worst affected by HIV in the world and accounts for one-third of the global HIV burden. 2 HIV infection has been reported to negatively impact the neurologic development of children, including cognitive impairment, developmental deficits, and psychomotor dysfunctions.…”

Depressão como fator de risco para não adesão aos ARTs em homens vivendo com HIV em São Paulo

“…Estudos com pessoas vivendo com HIV indicam com veemência que depressão é impedimento a adesão a TARV (11), está associada à falha no início ou manutenção do regime medicamentoso indicado pelo profissional de saúde, assim como está associada a perda de consultas clínicas agendadas (12) (13). (31).…”

“…CEP: 04.121-000 Fax:(11)5087-9837 E-mail: cep@crt.saude.sp.gov.br SAO PAULO Endereco: SANTA CRUZ 81 Anexo Pesquisa 1o andar Bairro: VILA MARIANA UF: SP Município: Telefone: (11)5087-9837 CEP: 04.121-000 Fax: (11)5087-9837 E-mail: cep@crt.saude.sp.gov.br SAO PAULO…”