Prevalence and Incidence of Senile and Multi-Infarct Dementia in the Lundby Study: A Comparison between the Time Periods 1947–1957 and 1957–1972

Rorsman, Birgitta; Hagnell, Olle; Lanke, Jan

doi:10.1159/000118254

Cited by 105 publications

(59 citation statements)

References 8 publications

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“…Nevertheless, we believe the two stage model of disease progression used here, produces useful estimates of the numbers of patients requiring a high level of care roughly equivalent to that provided by a health care facility such as a nursing home. Epidemiological surveys of the percentage of cases with severe disease have ranged between 2% to over 50% (14)(15)(16). Such wide variation could result either from differences in survey methodology and diagnostic criteria, or sampling enrollment biases.…”

Section: Discussionmentioning

confidence: 99%

Forecasting the global burden of Alzheimer's disease

Brookmeyer

Johnson

Ziegler-Graham

et al. 2007

Alzheimer's & Dementia

2,918

1,908

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Section: Discussionmentioning

confidence: 99%

Forecasting the global burden of Alzheimer's disease

Brookmeyer

Johnson

Ziegler-Graham

et al. 2007

Alzheimer's & Dementia

2,918

1,908

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“…Some articles reported that the incidence or prevalence remained stable over time. [3][4][5][6][7] One article reported a decline in rates, 8 while others suggested that rates increased. 9-12 These increases were particularly large when the analyses used cases identified through the Medicare system.…”

Section: Discussionmentioning

confidence: 99%

Change in risk of Alzheimer disease over time

Hebert

Bienias²,

Aggarwal³

et al. 2010

Neurology

137

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Objective: To assess whether the risk of incidence of Alzheimer disease (AD) varies over time. The increase in numbers of people at the oldest ages in the population will bring an increase in the number of people with AD. Projections of the size of the increase assume the risk of AD is constant.Methods: All persons age 65 or older in a biracial, geographically defined area were invited to participate in a home interview every 3 years. From the approximately 10,000 participants, stratified random samples were selected for detailed clinical evaluation. At each cycle, individuals determined free of AD in a previous cycle, either by examination or by high score on cognitive function tests, were sampled in the subsequent cycle for evaluation for incident AD. The evaluations for disease were structured and uniform across time. These analyses include 1,695 subjects evaluated for incident disease from 1997 through 2008.Results: AD developed in 360 participants. Change over time in risk of incident disease was assessed in logistic regression analyses including evaluation date and controlling for age, gender, education, race, interval from disease-free designation to evaluation for incident disease, and sample design. The time variable (in years) was not significant (odds ratio ϭ 0.970, 95% confidence interval ϭ 0.902 to 1.044). Conclusions:The null relation of evaluation date to disease incidence suggests no recent change in risk of AD over time, and supports this assumption for projections of AD. Neurology Alzheimer disease (AD) has severe consequences for both the individuals involved and the burden on the health care system. Projections of the number of cases over time assumed that the risk of AD would remain constant. 1,2 Evidence for an increasing or decreasing risk of disease would demonstrate the need for revised projections.Studies of the possible changes in AD risk over time have had differing results. Some articles reported that the incidence or prevalence remained stable over time. [3][4][5][6][7] One article reported a decline in rates, 8 while others suggested that rates increased. 9-12 These increases were particularly large when the analyses used cases identified through the Medicare system. AD also has increased as the underlying cause of death on death certificates. 13,14 While at least some of this increase was probably due to increased interest in the disease, the numbers raise disturbing questions of whether the occurrence of AD is increasing over time. In this article, we report direct assessment of change in uniformly ascertained incidence of AD over 11 years.METHODS Study population. We used data from a longitudinal study of AD among people aged 65 or older in a geographically defined community of 3 neighborhoods of Chicago, IL.

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“…The Lundby study in Sweden 13 reported no significant change in the prevalence or incidence of either multiinfarct dementia or what was described at the time as "senile dementia" (now most probably AD) over the period from 1947 to 1972. In Rochester in the USA, 14 the meticulously maintained healthcare register suggested no change in the prevalence of either AD or dementia between 1975 and 1980.…”

Section: Variations In Dementia Prevalence Between Countriesmentioning

confidence: 98%

Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology

Smith¹,

Lamping²,

Banerjee

et al. 2005

Health Technol Assess

520

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Prevalence and Incidence of Senile and Multi-Infarct Dementia in the Lundby Study: A Comparison between the Time Periods 1947–1957 and 1957–1972

Cited by 105 publications

References 8 publications

Forecasting the global burden of Alzheimer's disease

Forecasting the global burden of Alzheimer's disease

Change in risk of Alzheimer disease over time

Measurement of health-related quality of life for people with dementia: development of a new instrument (DEMQOL) and an evaluation of current methodology

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