HIV/AIDS is a major public health problem continues to affect millions of people all over the world. An average of 79.3 million people died from HIV-related causes since the start of the epidemic. HIV has many different routes of transmission, and the frequency of transmission and the most common mode of transmission varies in different parts of the world. In Turkiye, there have been changes in epidemiological data on HIV over the years. This is a systematic review of studies on HIV/AIDS epidemiological studies and reportes in Turkiye since the first case was reported. The aim of this review is to analyze epidemiologic publications since the first case was seen in Turkiye and to evaluate the overall situation. All publications published between 1985 and 2020 were reviwed. 756 studies were identified and 54 original articles, guidelines, reports and symposium presentation were included. The types of researches, the number of participants, the participant groups, study location, gender and mode of transmission were examined.HIV/AIDS prevelance is increasing. The mode of transmission is common through heterosexual transmission and men who have sex with men transmission mode is increasing. It was seen that there were not enough large-scale studies at the national level. Further studies on HIV/AIDS should be conducted as national level or multicenter.