Prevalence and incidence rates of atrial fibrillation in Norway 2004–2014

Kjerpeseth, Lars Jøran; Igland, Jannicke; Selmer, Randi; Ellekjær, Hanne; Tveit, Arnljot; Berge, Trygve; Kalstø, Silje Madeleine; Christophersen, Ingrid E.; Myrstad, Marius; Skovlund, Eva; Egeland, Grace M.; Tell, Grethe S.; Ariansen, Inger

doi:10.1136/heartjnl-2020-316624

Cited by 32 publications

(28 citation statements)

References 28 publications

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“…Furthermore, in all Nordic countries, citizens have an individual identification number, which makes it possible to combine national register data. Nationwide register studies of AF have been published from Nordic countries merging also data from several separate registers [13][14][15]. However, these countries do not have a national primary health care registry, and nationwide studies have been based only on cases found in the hospital setting.…”

Section: Discussionmentioning

confidence: 99%

The nationwide Finnish anticoagulation in atrial fibrillation (FinACAF): study rationale, design, and patient characteristics

et al. 2022

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Atrial fibrillation (AF) is a major cause of ischemic stroke and the number of AF patients is increasing. Thus, up-to-date multifaceted data about the characteristics of AF patients, their treatments, and outcomes are urgently needed. The Finnish anticoagulation in atrial fibrillation (FinACAF) study has collected comprehensive data on all Finnish AF patients from 1st January 2004 to 31st December 2018. The aim of this paper is to describe the study rationale, the process of integrating data from the applied resources and to define the study cohort. Using national unique personal identification number, individual patient data is linked from nationwide health care registries (primary, secondary, and tertiary care), drug purchases, education, and socio-economic status as well as places of domicile, incomes, and taxes. Six regional laboratory databases (~ 282,000, 77% of the patients) are also included. The study cohort comprises of a total of 411,000 patients. Since the introduction of the national primary care register in 2012, 9% of all AF patients were identified outside hospital care registers. The prevalence of AF in Finland—4.1% of whole population—is for the first time now established. The FinACAF study allows a unique possibility to investigate the epidemiology and socio-medico-economic impact of AF as well as the cost effectiveness of different AF management strategies in a completely unselected, nationwide population. This article provides the rationale and design of the study together with a summary of the characteristics of the cohort.

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Section: Discussionmentioning

confidence: 99%

The nationwide Finnish anticoagulation in atrial fibrillation (FinACAF): study rationale, design, and patient characteristics

et al. 2022

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“…A considerable proportion of people are affected by atrial fibrillation (AF), and the prevalence is estimated to grow rapidly because of an aging population. 1 , 2 , 3 In addition to considerable limitations in quality of life, the incidence of major cardiac events, such as ischemic stroke, heart failure, and death, is substantially increased in people with AF. 4 , 5 , 6 , 7 Recent efforts mainly focus on the prevention of ischemic stroke and treatment of AF through ablation procedures, and progress has been achieved.…”

Section: Introductionmentioning

confidence: 99%

Association of Depression With Atrial Fibrillation in South Korean Adults

Lee

Han

et al. 2022

JAMA Netw Open

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IMPORTANCEThe risk of atrial fibrillation (AF) in people with depression is not fully known.Depression is associated with sympathetic activation and emotional stress, which might increase the risk of new-onset AF.OBJECTIVE To assess the incidence of new-onset AF in those with and without depression using data from a nationwide health care database. DESIGN, SETTING, AND PARTICIPANTSThis cohort study obtained data from the Korean National Health Insurance Service database and enrolled people who underwent a nationwide health checkup in 2009. People younger than 20 years and those with a history of heart valve surgery, previous diagnosis of mitral stenosis, or who were diagnosed with AF between January 1, 2002 and December 31, 2008 were excluded. The risk of new-onset AF (occurring between 2009 and 2018) was compared in people who were and were not diagnosed with depression within a year before the 2009 nationwide health checkup. Data were analyzed between August 1, 2020 and October 31, 2020. EXPOSURE Previous diagnosis of depression. MAIN OUTCOMES AND MEASURES Cumulative incidence and risk of new-onset AF between 2009and 2018 in participants with and without depression. Kaplan-Meier analysis was conducted to assess incidence of AF, and Cox proportional hazards regression was used to calculate adjusted and unadjusted hazard ratios (HRs) and 95% CIs. RESULTSA total of 5 031 222 individuals with a mean (SD) age of 46.99 (14.06) years (2 771 785 men [55.1%]) were included in the analysis; of these individuals, 148 882 (3.0%) had a diagnosis of depression in the year before the 2009 health checkup and 4 882 340 (97%) did not. People with depression vs those without depression were older (aged 56.7 vs 46.7 years) and more likely to be women (96 472 [64.8%] vs 2 162 965 [44.3%]). Prevalence of hypertension, diabetes, dyslipidemia, and heart failure was higher in the depression group. The cumulative incidence of new-onset AF was significantly higher in people with depression vs without depression in the Kaplan-Meier analysis and showed steady divergence throughout 10 years of follow-up (cumulative incidence, 4.44% vs 1.92%; log-rank P < .001). After adjusting for covariates, depression was associated with a 25.1% increased risk of new-onset AF (HR, 1.25; 95% CI, 1.22-1.29; P < .001). People with recurrent episodes of depression showed even higher risk of new-onset AF (HR, 1.32; 95% CI, 1.27-1.37; P < .001). Young age and female sex had significant interactions with depression, which suggests that young people and women with depression may have an increased risk of new-onset AF.CONCLUSIONS AND RELEVANCE This study found that depression was associated with a significantly increased cumulative incidence and risk of new-onset AF. Recurrent episodes of (continued) Key Points Question Is depression associated with increased risk of new-onset atrial fibrillation (AF)? Findings In this cohort study of 5 031 222 individuals with a follow-up of 43 115 042 person-years, depression was associated with a higher cumulative incidence of ...

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“… 2 It was estimated that the age-standardized prevalence of AF in adults ranged between 2% and 4%, with an increase of 2.3 times. 3 , AF has now become a considerable healthcare cost burden as well as a critical public health issue in China. 4 …”

Section: Introductionmentioning

confidence: 99%

Population Attributable Risks of Potential Modifiable Factors for Atrial Fibrillation in China: A National Survey

Nie¹,

Xu²,

Chen³

et al. 2022

RMHP

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Background There is an association between atrial fibrillation (AF) and overall mortality as well as mobility. It is not known, however, what the preventable burden of AF in China is. This study aims to identify what proportion of the burden of AF may be avoided by modifiable risk factors. Methods As part of the China National Stroke Screening and Prevention Project, 726,451 adults aged ≥40 years were enrolled in a representative cross-sectional study. The following seven factors have been categorized as modifiable risk factors for AF: body mass index, smoking, alcohol consumption, physical inactivity, hypertension, diabetes mellitus, and dyslipidemia. In order to calculate population-attributable risks (PARs), odds ratios (ORs) were calculated for selected risk factors. Results The crude ORs increased with age (ORs ranged from 1.92 to 4.02). A total of 18,736 cases of prevalent AF have been identified. The overall prevalence of AF was 2.6%. The crude ORs increased with age (ORs range 1.92–4.03). The adjusted ORs and the corresponding confidence intervals (CIs) for these seven modifiable factors were 1.16 (95% confidence interval [CI]: 1.12–1.19), 1.56 (95% CI: 1.49–1.62), 2.15 (95% CI: 2.02–2.28), 2.07 (95% CI: 2.01–2.14), 2.71 (95% CI: 2.62–2.79), 2.10 (95% CI: 2.02–2.19), 2.52 (95% CI: 2.44–2.60), and 3.32 (95% CI: 3.18–3.48), respectively. Accordingly, 59.3% of all cases of AF could be explained by having these modifiable risk factors, among which hypertension accounted for the greatest share. Conclusion In China, hypertension is the leading preventable cause of AF, and more than half of these cases can be prevented through improving those modifiable risk factors.

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Prevalence and incidence rates of atrial fibrillation in Norway 2004–2014

Cited by 32 publications

References 28 publications

The nationwide Finnish anticoagulation in atrial fibrillation (FinACAF): study rationale, design, and patient characteristics

The nationwide Finnish anticoagulation in atrial fibrillation (FinACAF): study rationale, design, and patient characteristics

Association of Depression With Atrial Fibrillation in South Korean Adults

Population Attributable Risks of Potential Modifiable Factors for Atrial Fibrillation in China: A National Survey

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