Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Tapper-Jones, L; Aldred, Michael J.; Walker, DM

doi:10.1136/jcp.33.3.282

Cited by 49 publications

(22 citation statements)

References 14 publications

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“…However, in conclusion, it is hypothesized that low-molecular-weight proteins in the salivary pellicle are responsible for the reduced adherence of yeasts . This finding would be in line with clinical findings of increased prevalence of intra-oral C. albicans in both patients with Sjogren's syndrome (Tapper-Jones et al, 1980) and patients with a reduced saliva production after radiotherapy who have a reduced life span of their silicone voice prostheses due to biofilm growth of yeasts (Hilgers and Balm, 1993). Salivary mucins have a role in the adherence and clearance of C. albicans intra-orally.…”

Section: (62) Later Studies (1980 To the Present)supporting

confidence: 81%

Denture Plaque and Adherence of Candida Albicans To Denture-Base Materials in Vivo and in Vitro

Radford

Challacombe

Walter

1999

Critical Reviews in Oral Biology & Medicine

299

249

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The aim of this paper is to review our understanding of the mechanisms and clinical significance of adhesion of C. albicans to denture-base materials in relation to denture plaque and denture-related stomatitis. Earlier reports in the literature of a 65% prevalence level of denture-related stomatitis seem to be exaggerated. More recent studies indicate that denture-related stomatitis is considerably less common, particularly in normal healthy subjects. The etiology of the condition is discussed in this review, and although much of the literature supports the view that the condition is strongly associated with C. albicans, this is not always so. In some subjects, the cause appears to be related to a non-specific plaque. This review also considers the role of denture plaque in the pathogenesis of denture-related stomatitis, the sequential development of denture plaque, and its colonization by Candida organisms. Designing controlled in vivo studies is difficult, and as a consequence, many investigators have had to resort to in vitro studies. The majority of these studies have attempted to investigate the hydrophobicity of C. albicans, relating the surface free-energy of denture-base materials, particularly acrylic resin, to that of the organism. Surprisingly little work has been directed at surface roughness and how it affects retention of organisms. Further, no attention has been paid to the properties and character of the surface, other than average surface roughness, as it affects adhesion. A comparison of results from in vitro studies on the effect on adhesion of pre-coating the surfaces of denture-base materials with saliva has produced equivocal conclusions. This is largely due to little standardization of experimental protocols between studies, particularly in the collection and handling of the saliva used. In conclusion, the review strongly supports the suggestion that adherence of C. albicans to denture-base materials in vitro is related to the hydrophobicity of the organism. The clinical significance of the observation and the mechanisms for the development and maturation of denture plaque are yet to be understood. There is a clear need for further investigation of other factors that may moderate the adhesion of organisms and subsequent colonization of denture-base materials.

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Section: (62) Later Studies (1980 To the Present)supporting

confidence: 81%

Denture Plaque and Adherence of Candida Albicans To Denture-Base Materials in Vivo and in Vitro

Radford

Challacombe

Walter

1999

Critical Reviews in Oral Biology & Medicine

299

249

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“…The inverse relationship between the Candida population and flow rate is also recently reported in Sjogren's syndrome by TapperJones et al 26 Since women harbored significantly more yeasts (contrary to recent findings by Arendorf and Walker27) and had a lower flow rate, the direct cause-effect relationship between these factors is a probable explanation of these findings, though not the only one. The correlation between high yeast counts and low pH has also been reported by Arendorf and Walker, 27 Young et al,28 and Baqai and Hafiz.29…”

Section: Discussionmentioning

confidence: 52%

The Relation of Stimulated Salivary Flow Rate and pH to Lactobacillus and Yeast Concentrations in Saliva

Parvinen

Larmas

1981

J Dent Res

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“…The positive predictive value of the AECG criteria is between 54-77% and the negative predictive value is between 94-98% as compared to the classification criteria of 1986 31. Xerostomia may lead to secondary problems like oral candidiasis (33%), dental carries (65%) and periodontal disease 36, 37. Xerophtalmia may result in photosensitivity, chronic irritation and destruction of the corneal epithelium and ocular infections.…”

Section: Clinical Presentationmentioning

confidence: 99%

Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment

Both¹,

Dalm²,

Hagen³

et al. 2017

Int. J. Med. Sci.

183

110

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Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, characterized by lymphocytic infiltration of the secretory glands. This process leads to sicca syndrome, which is the combination of dryness of the eyes, oral cavity, pharynx, larynx and/or vagina. Extraglandular manifestations may also be prevalent in patients with pSS, including cutaneous, musculoskeletal, pulmonary, renal, hematological and neurological involvement. The pathogenesis of pSS is currently not well understood, but increased activation of B cells followed by immune complex formation and autoantibody production are thought to play important roles. pSS is diagnosed using the American-European consensus group (AECG) classification criteria which include subjective symptoms and objective tests such as histopathology and serology. The treatment of pSS warrants an organ based approach, for which local treatment (teardrops, moistures) and systemic therapy (including non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDS) and biologicals) can be considered. Biologicals used in the treatment of pSS mainly affect the total numbers of B cells (B cell depletion (Rituximab)) or target proteins required for B cell proliferation and/or activation (e.g. B cell activating factor (BAFF)) resulting in decreased B cell activity.The aim of this review is to provide physicians a general overview concerning the pathogenesis, diagnosis and management of pSS patients.

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Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Cited by 49 publications

References 14 publications

Denture Plaque and Adherence of Candida Albicans To Denture-Base Materials in Vivo and in Vitro

Denture Plaque and Adherence of Candida Albicans To Denture-Base Materials in Vivo and in Vitro

The Relation of Stimulated Salivary Flow Rate and pH to Lactobacillus and Yeast Concentrations in Saliva

Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment

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