Prevalence and Levels of Serum Antibodies to Gram Negative Microorganisms in Turkish Patients with HLA-B27 Positive Acute Anterior Uveitis and Controls

Onal, Sumru; Kazokoğlu, Haluk; Incili, Burcin; Demiralp, Emel; Yavuz, Şule

doi:10.1080/09273940600977241

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…pylori in the development and recurrence of HLA-B27-positive AAU [ 13 , 18 ]. On the other hand, Onal et al reported that there was no significant association between gram-negative organisms and AAU [ 19 ]. In this study, we showed an inverse association between H .…”

Section: Discussionmentioning

confidence: 99%

The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis

Bae

Kim

2015

PLoS ONE

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PurposeTo investigate an association between Helicobacter pylori seropositivity and HLA-B27-positive acute anterior uveitis (AAU) in Korean patients.MethodsRetrospective analysis was performed with data from 106 patients previously diagnosed with AAU without clinical evidence of spondyloarthropathy. Serum immunoglobulin G antibodies to H. pylori were measured by enzyme-linked immunosorbent assay, and HLA typing was performed using polymerase chain reaction of DNA amplification. We included 72 non-uveitis patients and 35 age- and sex-matched healthy controls in the study.ResultsOf the 106 patients with AAU, 41 (38.7%) were HLA-B27-positive, and 45 (42.5%) were seropositive for H. pylori. Patients with HLA-B27-positive AAU had a significantly lower prevalence of H. pylori seropositivity compared to those with HLA-B27-negative AAU and healthy controls (24.4% vs. 53.8%, p = 0.003; 24.4% vs. 57.1%, p = 0.004, respectively). In the non-uveitis group, however, HLA-B27-positive patients exhibited similar H. pylori seropositivity prevalence to HLA-B27-negative patients and healthy controls (45.5% vs. 55.7%, p = 0.529; 45.5% vs. 57.1%, p = 0.497, respectively). In multivariate analysis, a low prevalence of H. pylori seropositivity was significantly associated with HLA-B27-positive AAU (odds ratio = 0.340, 95% confidence interval 0.135–0.855, p = 0.022).ConclusionsOur results suggest an inverse association between H. pylori seropositivity and HLA-B27-positive AAU. Further investigation of this association is needed, given the low prevalence of H. pylori seropositivity observed in patients with HLA-B27-positive AAU.

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Section: Discussionmentioning

confidence: 99%

The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis

Bae

Kim

2015

PLoS ONE

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“…Two small serological studies did not find an association between AAU and C. trachomatis when comparing with age-matched controls, nor did they find an association with any enteric infection suspected of causing ReA ( 107 , 108 ). Neither study measured ASCAs.…”

Section: The Usual Suspectsmentioning

confidence: 93%

“…ASCAs are strongly associated with uveitis in spondyloarthritis patients ( 16 ), but antibodies against various bacteria suspected of causing ReA are not ( 107 , 108 ). Similarly, circulating CD4+ T cells in uveitis patients are more sensitive than controls to fungal antigens ( C. albicans ) after a 24-h antigen exposure period ( 127 ), whereas sensitivity to bacterial antigens ( Staphylococcus aureus, Clostridium tetani , and Mycobacterium tuberculosis ) and protist antigens ( Toxoplasma gondii ) are similar in both groups ( 127 ).…”

Section: Links With Fungimentioning

confidence: 99%

Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall–King Hypothesis

Laurence¹,

Asquith

Rosenbaum

2018

Front. Med.

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Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis. Recent studies suggest an unrecognized sexually acquired fungal infection may be involved in prostate cancer and perhaps multiple sclerosis. This warrants reanalyzing the Catterall–King hypothesis based on the current literature. In the last decade, many links between spondyloarthritis and fungal infections have been found. Antibodies against the fungal cell wall component mannan are elevated in spondyloarthritis. Functional polymorphisms in genes regulating the innate immune response against fungi have been associated with spondyloarthritis (CARD9 and IL23R). Psoriasis and inflammatory bowel disease, two common comorbidities of spondyloarthritis, are both strongly associated with fungi. Evidence reviewed here lends credence to the Catterall–King hypothesis and implicates a common fungal etiology in prostate cancer, benign prostatic hyperplasia, multiple sclerosis, psoriasis, inflammatory bowel disease, and spondyloarthritis. However, the evidence available at this time is insufficient to definitely confirm this hypothesis. Future studies investigating the microbiome in relation to these conditions should screen specimens for fungi in addition to bacteria. Future clinical studies of spondyloarthritis should consider antifungals which are effective in psoriasis and multiple sclerosis, such as dimethyl fumarate and nystatin.

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“…Liegen zusätzlich eine Konjunktivitis und eine Urethritis vor, so spricht man von einem Reiter-Syndrom. Bei erwachsenen HLA-B27-positiven oder -negativen Patienten mit isolierter akuter anteriorer Uveitis (AAU) fanden sich dagegen keine eindeutigen Assoziationen mit Infektionen durch gramnegative Bakterien [9,17], jedoch mit Chlamydia pneumoniae [10] und mit Helicobacter pylori [18,19]. Patienten mit AAU und häufigen Uveitisschüben wiesen häufiger Antikçrper gegen die untersuchten Erreger auf als Patienten ohne oder mit seltenen Uveitisrezidiven, was als Hinweis auf wiederholte Infektionen, auf Antigenpersistenz oder auf eine erhçhte Reagibilität des angeborenen Immunsystems gedeutet wurde [9].…”

Section: Infektionsassoziierte Entzündlich Rheumatische Erkrankungenunclassified

Andere entzündlich rheumatische Erkrankungen mit Uveitis neben der juvenilen idiopathischen Arthritis

Michels¹,

Greiner²,

Heinz³

et al. 2007

Klin Monatsbl Augenheilkd

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In childhood and adolescence, uveitis is part of the clinical spectrum of many inflammatory-rheumatic diseases. Besides juvenile idiopathic arthritis juvenile, ankylosing spondylitis, infection-associated arthritides, infantile sarcoidosis, systemic vasculitides, inflammatory bowel diseases, hereditary autoinflammatory syndromes and the TINU syndrome have to be excluded. These inflammatory diseases can be differentiated clinically in connection with immunogenetic and molecular genetic investigations. Early diagnosis of uveitis as well as the underlying diseases is mandatory for an early treatment and therefore for a good prognosis.

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Prevalence and Levels of Serum Antibodies to Gram Negative Microorganisms in Turkish Patients with HLA-B27 Positive Acute Anterior Uveitis and Controls

Cited by 11 publications

References 38 publications

The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis

The Rate of Helicobacter pylori Seropositivity in a Group of Korean Patients with HLA-B27-Associated Acute Anterior Uveitis

Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall–King Hypothesis

Andere entzündlich rheumatische Erkrankungen mit Uveitis neben der juvenilen idiopathischen Arthritis

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