Prevalence and Management of Gastrointestinal Complications in Lung Transplant Patients: MITOS Study Group

Bravo, Carles; Gispert, Pilar; Borro, J.M.; Torre, M. de la; Cifrián, José Manuel; Rozas, S. Fernández; Goñi, F. Zurbano

doi:10.1016/j.transproceed.2007.07.054

Cited by 36 publications

(20 citation statements)

References 13 publications

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“…Complications such as gastrointestinal problems (diarrhea (51–53), nausea and vomiting (54, 55)) and renal failure (56–58) are common after lung transplantation, often requiring hospital readmission. Many of these complications (e.g., nausea) are likely side effects of immunosuppressants and anti-viral medications (55).…”

Section: Discussionmentioning

confidence: 99%

Pattern and Predictors of Hospital Readmission During the First Year After Lung Transplantation

Alrawashdeh

Zomak²,

Dew

et al. 2017

American Journal of Transplantation

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Hospital readmission after lung transplantation negatively impacts quality of life and resource utilization. A secondary analysis of data collected prospectively was conducted to identify the pattern (incidence, count, cumulative duration), reasons and predictors of readmission for 201 lung transplant recipients (LTR) assessed at 2, 6, and 12 months post-discharge. The majority of LTRs (83.6%) were readmitted, and 64.2% had multiple readmissions. The median cumulative readmission duration was 19 days. The main reasons for readmission were: other than infection or rejection (55.5%), infection only (25.4%), rejection only (9.9%), and infection and rejection (0.7%). LTRs who required reintubation (odd ratio [OR]=1.92; p=.008) or discharged to care facilities (OR=2.78; p=.008) were at higher risk for readmission with a 95.7% cumulative incidence of readmission at 12 months. Thirty-day readmission (40.8%) was not significantly predicted by baseline characteristics. Predictors for higher readmission count were lower capacity to engage in self-care (incidence rate ratio [IRR]=0.99; p=.03) and discharge to care facilities (IRR=1.45; p=.01). Predictors for longer cumulative readmission duration were older age (arithmetic mean ratio [AMR]=1.02; p=.009), return to ICU (AMR=2.00; p=.01), and lower capacity to engage in self-care (AMR=0.99; p=.03). Identifying LTRs at risk may assist in optimizing pre-discharge care, discharge planning, and long-term follow-up.

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Section: Discussionmentioning

confidence: 99%

Pattern and Predictors of Hospital Readmission During the First Year After Lung Transplantation

Alrawashdeh

Zomak²,

Dew

et al. 2017

American Journal of Transplantation

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“…Lung transplant recipients are at higher risk of developing diverticular disease and related complications when compared to an age‐matched general population . The broad spectrum of diverticular disease described in lung transplant recipients ranges from uncomplicated diverticulitis to colonic perforation and death . Although the increased incidence of diverticular disease and related complications has been reported previously, the specific impact on post‐transplant outcomes remains unclear and no factors have been identified which accurately predict the development of complicated diverticulitis.…”

Section: Introductionmentioning

confidence: 99%

Association between diverticular disease requiring surgical intervention and mortality in the postlung transplant population ‐ a retrospective cohort study

et al. 2019

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Summary Lung Transplant recipients are at increased risk of complicated diverticular disease. We aim to assess the rate of diverticular surgery in a postlung transplantation population and identify risk factors for surgery. We performed a retrospective cohort study of lung transplant recipients from 2007 to 2011. Demographic variables were evaluated with the Mann–Whitney U and chi‐squared tests. Cox regression was performed to evaluate 1‐ and 2‐year landmark survival, assess predictor variables of diverticular surgery and evaluate impact of surgery on CLAD development. Of 17 of 158 patients (10.7%) underwent diverticular‐related surgery. Surgical patients had significantly worse survival than nonsurgical patients at 1 year [aHR 2.93 (1.05–8.21), P = 0.041] and 2 year [aHR 4.17 (1.26–13.84), P = 0.020] landmark analyses. Transplant indication of alpha‐1 antitrypsin disease and cystic fibrosis were significantly associated with the need for diverticular surgery. Emergent surgery was associated with poorer survival [aHR 5.12(1.00–26.27), P = 0.050]. Lung transplant patients requiring surgery for complicated diverticular disease have significantly poorer survival than those who do not require surgery. Surgery was more common in patients transplanted for A1AT and CF. Optimal assessment and risk stratification of diverticular disease is necessary to prevent excessive morbidity and mortality following transplantation.

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“…In the pediatric population, the possibility of PTLD should be investigated since it carries a high mortality [181]. Other described infectious intra-abdominal complications include digestive perforation (seen in 6%) [182], retroperitoneal abscesses, cholecystitis, perianal abscesses, esophagitis, pancreatitis, pancreatic abscesses, hepatitis, diverticulitis, appendicitis, CMV colitis, megacolon, and colon rupture [180,183,184]. In developing countries, persistently abnormal liver enzymes should prompt testing for HEV.…”

Section: Abdominal/genitourinarymentioning

confidence: 99%

Infections in Heart, Lung, and Heart-Lung Transplantation

Henao-Martínez

Montoya

2019

Principles and Practice of Transplant Infectious Diseases

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Prevalence and Management of Gastrointestinal Complications in Lung Transplant Patients: MITOS Study Group

Cited by 36 publications

References 13 publications

Pattern and Predictors of Hospital Readmission During the First Year After Lung Transplantation

Pattern and Predictors of Hospital Readmission During the First Year After Lung Transplantation

Association between diverticular disease requiring surgical intervention and mortality in the postlung transplant population ‐ a retrospective cohort study

Infections in Heart, Lung, and Heart-Lung Transplantation

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