Prevalence and molecular characterization of human herpes virus 6 and 7 in patients with pityriasis rosea using polymerase chain reaction in a tertiary care hospital, Puducherry

Murugaiyan, Rangaraj; Kaliyaperumal, Karthikeyan; Rangasamy, Balamurugan

doi:10.18203/issn.2455-4529.intjresdermatol20194632

Cited by 1 publication

(2 citation statements)

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“…The age distribution is generally reported to be between 10 and 35 years of age, similar to the age for primary infection of some viruses, probably due to intimacy during teenage and early adulthood years, which might be related to the spread of the agent [4,7,8]. Although there was a prevalence in women, no statistically significant variation between genders has been claimed [4].…”

Section: Discussionmentioning

confidence: 87%

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Association between Pityriasis Rosea (PR) and HHV-6/HHV-7 Infection: Importance of Sample Selection and Diagnostic Techniques

Aydin Kurc,

Erfan,

Kaya

et al. 2024

Diagnostics

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Recent studies have focused on the role of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) in PR etiology with varying results. In our study, with the approach that the discrepancy between the results may be related to the different samples and techniques used, we aimed to clarify the etiology by examining tissue and plasma samples using molecular methods and evaluating the results together with serological parameters. Skin biopsies and plasma samples of twenty-five PR patients were tested to detect HHV-6 and HHV-7 DNA using calibrated quantitative real-time polymerase chain reaction (CQ RT-PCR). IgG and IgM antibodies against HHV-6 and HHV-7 were tested by enzyme-linked immunosorbent assay and indirect immunofluorescence. Of the patient group, 64% were positive for HHV-6 IgG without IgM positivity. HHV-6 DNA was present in seven tissue and ten plasma samples. HHV-7 positivity was 100% and 12% for IgG and IgM antibodies, respectively. HHV-7 DNA was detected in four tissue samples and one plasma sample. Patients with HHV-7 DNA-positive plasma and tissue samples had also HHV-7 IgM antibodies. In conclusion, our results seem to support the role of HHV-6/HHV-7 in the etiology of PR. To clarify the etiology of PR and avoid confusion, the collection of different biological materials simultaneously and the usage of CQ RT-PCR as a diagnostic technique are recommended.

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Section: Discussionmentioning

confidence: 87%

“…Varying degrees of pruritus can be observed. Classically, there is complete remission mostly within 8-12 weeks [5,7,8]. PR may also have atypical presentations regarding the morphology and distribution of the lesions and the course of the disease.…”

Section: Discussionmentioning

confidence: 99%

Association between Pityriasis Rosea (PR) and HHV-6/HHV-7 Infection: Importance of Sample Selection and Diagnostic Techniques

Aydin Kurc,

Erfan,

Kaya

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

Prevalence and molecular characterization of human herpes virus 6 and 7 in patients with pityriasis rosea using polymerase chain reaction in a tertiary care hospital, Puducherry

Abstract: Original Research ArticlePrevalence and molecular characterization of human herpes virus 6 and 7 in patients with pityriasis rosea using polymerase chain reaction in a tertiary care hospital, Puducherry

Cited by 1 publication

References 7 publications

Association between Pityriasis Rosea (PR) and HHV-6/HHV-7 Infection: Importance of Sample Selection and Diagnostic Techniques

Association between Pityriasis Rosea (PR) and HHV-6/HHV-7 Infection: Importance of Sample Selection and Diagnostic Techniques

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