Prevalence and motor-functional correlates of frontotemporal-spectrum disorders in a large cohort of non-demented ALS patients

Poletti, Barbara; Aiello, Edoardo Nicolò; Consonni, Monica; Iazzolino, Barbara; Torre, Silvia; Solca, Federica; Faltracco, Veronica; Telesca, Alessandra; Palumbo, Francesca; Dalla Bella, Eleonora; Bersano, Enrica; Riva, Nilo; Verde, Federico; Messina, Stefano; Doretti, Alberto; Maranzano, Alessio; Morelli, Claudia; Calvo, Andrea; Silani, Vincenzo; Lauria, Giuseppe; Chiò, Adriano; Ticozzi, Nicola

doi:10.1007/s00415-024-12658-w

J Neurol

2024

DOI: 10.1007/s00415-024-12658-w

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Prevalence and motor-functional correlates of frontotemporal-spectrum disorders in a large cohort of non-demented ALS patients

Barbara Poletti,

Edoardo Nicolò Aiello,

Monica Consonni

et al.

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Education moderates the association between motor involvement and executive status in ALS

Aiello,

Poletti,

Consonni

et al. 2024

Euro J of Neurology

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BackgroundThis study aimed to determine whether educational attainment—a common proxy of cognitive reserve (CR)—influences the association between motor and cognitive/behavioural outcomes in a large cohort of ALS patients without dementia.MethodsN = 726 ALS patients without FTD were assessed for motor (ALSFRS‐R), cognitive (Edinburgh Cognitive and Behavioural ALS Screen, ECAS) and behavioural outcomes (ECAS‐Carer Interview, ECAS‐CI). CR was operationalized via educational attainment (in years). Moderation models were run on each subscale of the cognitive section of the ECAS and on the ECAS‐CI by addressing ALSFRS‐R as the predictor and education as the moderator.ResultsEducation was associated with both the ALSFRS‐R and all the cognitive subscales of the ECAS, while not with the ECAS‐CI. As to moderation models, a significant Education*ALSFRS‐R interaction was detected solely with regard to the ECAS‐Executive—with its simple slope‐based decomposition revealing that higher ALSFRS‐R scores were associated with higher scores on the ECAS‐Executive for patients with low (p < 0.001) and average (p = 0.007), while not high, levels of education.DiscussionEducation seems to moderate the association between motor involvement and executive status in ALS patients without dementia, thus possibly exerting a protective role towards both motor function and cognition in this population.

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Education moderates the association between motor involvement and executive status in ALS

Aiello,

Poletti,

Consonni

et al. 2024

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

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Prevalence and motor-functional correlates of frontotemporal-spectrum disorders in a large cohort of non-demented ALS patients

Cited by 1 publication

References 47 publications

Education moderates the association between motor involvement and executive status in ALS

Education moderates the association between motor involvement and executive status in ALS

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