Prevalence and multiplicity of HPV in HIV women in Minas Gerais, Brazil

Corrêa, Christine Miranda; Teixeira, Nara Chartuni Pereira; Araújo, Angela Cristina Labanca de; Carvalho, Nara de Oliveira; Castillo, Dora Méndez del; Campos, Rachel Rezende; Oliveira, Isaura Vargas; Alves, Antonio Rafael; França, Ana Flávia de Moura; Melo, Victor Hugo

doi:10.1016/s0104-4230(11)70088-4

Cited by 10 publications

(17 citation statements)

References 24 publications

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“…Correa et al (2011) found the frequency of HPV in HIV+ women to be 78.8%, with a similar frequency for HR-and LR-HPV genotypes. HPV-16 and -6 were the most frequent genotypes, and a high prevalence of HPV co-infections were also detected (64.8%).…”

Section: Molecular Prevalence Of Hpv and Genotypes In Hiv+ Women Accomentioning

confidence: 78%

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

Freitas

Suehiro²,

Consolaro³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Human papillomavirus is a virus that is distributed worldwide, and persistent infection with high-risk genotypes (HR-HPV) is considered the most important factor for the development of squamous cell cervical carcinoma (SCC). However, by itself, it is not sufficient, and other factors may contribute to the onset and progression of lesions. For example, infection with other sexually transmitted diseases such as human immunodeficiency virus (HIV) may be a factor. Previous studies have shown the relationship between HPV infection and SCC development among HIV-infected women in many regions of the world, with great emphasis on low-and middleincome countries (LMICs). Brazil is considered a LMIC and has great disparities across different regions. The purpose of this review was to highlight the current knowledge about HPV infection and cervical abnormalities in HIV+ women in Brazil because this country is an ideal setting to evaluate HIV impact on SCC development and serves as model of LMICs and low-resource settings.

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Section: Molecular Prevalence Of Hpv and Genotypes In Hiv+ Women Accomentioning

confidence: 78%

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

Freitas

Suehiro²,

Consolaro³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…Some authors, such as Corrêa et al (2011) and Pantanowitz and Michelow (2011), have demonstrated that the most frequent HPV genotypes in studies among the general population differ from those found in HIV-women.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of SCCA is particularly high in HIV+ men and women (Poggio, 2011). HIV+ women more frequently present persistent infection with multiple HPV genotypes (Corrêa et al, 2011;Pantanowitz and Michelow, 2011), probably owing to the inability of an HIV-compromised system to control the expression and replication of HPV (Tornesello et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

HPV infection-associated anogenital cyto-colpo-histological findings and molecular typing in HIV-positive women

et al. 2015

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ABSTRACT. HIV and human papillomavirus (HPV) coinfection is increasing, especially in the anal canal (AC) and cervico-vaginal regions.We identified anal epithelium abnormalities related to high-risk HPV (HR-HPV) lesions in the lower genital tracts (LGTs) of HIV-positive women, described the HPV genotypes identified, and assessed the expression of E6/E7 oncogenes in coinfected patients. Ninety-eight women were enrolled in groups combining HIV status and presence or absence of HPV in the LGT. Anal and cervical smears were collected for cytology and HR-HPV assays using Cobas ® and/ or PapilloCheck ® . Samples with highly oncogenic HPV genotypes were confirmed by NucliSENS EasyQ ® . Forty-two HIV-positive (25-52; mean age 39.5) and 56 HIV-negative (18-58; mean age 35.7) patients were included. E2 and C1 groups presented AC alterations (P = 0.002); altered images HPV-associated anogenital cytology in HIV-positive women for high-resolution anoscopy were higher in E1 and C2 (P < 0.001). Of the 29 women with alterations, 41.38% were HIV-negative and 58.62% were HIV-positive (P < 0.001). HIV-positive patients accounted for 29% of the anal high-grade squamous intraepithelial lesions (P = 0.015). The Cobas ® positive result frequency was higher in three AC groups than in the other groups. There was variation in the number of HPV types in the cervicovaginal samples among the study groups (P < 0.001). Anal cytology and anoscopy showed more altered findings in HIV-positive patients with HPV in the LGT. HR-HPV anal infections by various genotypes are common and are associated with cervical infections in HIV-positive patients. E6/E7 expression is apparently more common in the AC of HIV-positive women.

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“…Estudo de revisão mostrou prevalên-cias variando de 7 a 70%, com metade das publicações ressaltando prevalências inferiores a 20% 22 . Dois estudos brasileiros mostraram prevalências de 87, e 78,8% 26,33 . Os resultados deste estudo foram de 55,5%, também de acordo com a literatura.…”

Section: Métodosunclassified

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

Ceccato¹,

Lopes²,

Nascimento³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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Resumo OBJETIVO: Realizar estudo comparativo entre mulheres positivas e negativas para o vírus da imunodeficiência humana (HIV), analisando: prevalência de neoplasia intraepitelial cervical (NIC) e infecção cervical pelo papilomavírus humano (HPV); risco viral e relação com desenvolvimento de NIC; parâmetros sociodemográficos e de comportamento que influenciaram na presença de infecção cervical por HPV e NIC. MÉTODOS: Estudo comparativo entre mulheres positivas e negativas para o HIV, sendo analisadas, respectivamente, 202 e 171 mulheres para avaliar a prevalência de NIC e 164 e 100 mulheres para avaliar a prevalência de infecção cervical pelo HPV. Em todas as consultas foram realizados: coleta de amostras cervicais para realização de citologia oncótica e reação em cadeia da polimerase (PCR) para detecção do DNA-HPV; colposcopia; questionário padronizado para coleta de dados demográficos/comportamentais; biópsia de todas as alterações colposcópicas. O exame histopatológico foi o padrão-ouro para o diagnóstico de NIC. RESULTADOS: A prevalência de NIC foi de 2,4 e 15,3% (p<0,001) e de infecção cervical pelo HPV foi de 37,1 e 55,5% (p=0,002), respectivamente, nas negativas e positivas para o HIV. As soropositivas tiveram mais infecção por HPV de alto risco (35,7 e 23,6%; p=0,02) e por múltiplos tipos (6,2 e 0%). O HPV 16 foi o tipo prevalente, ocorrendo em 11,3 e 10,2% das positivas e negativas para o HIV e também nas mulheres que tiveram NIC nos dois grupos. Os fatores associados ao desenvolvimento de NIC foram: infecção pelo HIV (HT=4,64; IC95% 2,23-9,65), idade (HT=0,95; IC95% 0,93-0,98 para cada ano de vida) e estado civil (HT=0,49; IC95% 0,30-0,80). Os fatores associados à infecção pelo HPV foram: presença do HIV (HT=2,72; IC95% 1,77-4,17), maior número de parceiros sexuais (HT=1,87; IC95% 1,23-2,84), idade (HT=0,97; IC95% 0,95-0,99 para cada ano de vida) e estado civil (HT=0,65: IC95% 0,42-1,0 para união estável/viúvas). CONCLUSÃO: A prevalência de NIC e infecção cervical pelo HPV foi maior nas mulheres positivas para o HIV, que também apresentaram mais infecções por HPV de alto risco e múltiplos tipos. O tipo 16 foi o predominante nos dois grupos e nas mulheres que tiveram NIC. As mulheres com mais idade e união estável/viúvas tiveram menor chance de adquirir infecção cervical por HPV e NIC. AbstractPURPOSE: To conduct a comparative study between two groups of women (HIV positive and negative) analyzing: the prevalence of cervical intraepithelial neoplasia (CIN) and cervical HPV infection; viral risk and relationship with development of CIN; and sociodemographic and behavioral parameters that influence cervical HPV infection and the development of CIN. METHODS: A cross-sectional study in which 202 HIV-positive women and 164 HIV-negative women were analyzed to assess the prevalence of CIN and 171 HIV-positive women and 160 HIV-negative women were analyzed to assess the prevalence of cervical HPV infection. The following procedures were performed on the occasion of each medical visit: collection of cervical sa...

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Prevalence and multiplicity of HPV in HIV women in Minas Gerais, Brazil

Cited by 10 publications

References 24 publications

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

HPV Infection and Cervical Abnormalities in HIV Positive Women in Different Regions of Brazil, a Middle-Income Country

HPV infection-associated anogenital cyto-colpo-histological findings and molecular typing in HIV-positive women

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

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