Prevalence and Natural History of Alcoholic Liver Disease

Schwartz, Jonathan M.; Reinus, John F.

doi:10.1016/j.cld.2012.08.001

Cited by 123 publications

(84 citation statements)

References 27 publications

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“…In addition to the qualitative analysis, the following parameters were analyzed for the nucleus and cytoplasm of hepatocytes: area, perimeter, maximum and minimum diameter and form factor. Six photos were taken of each fragment in 400 fields, 3 photos of the portal region and 3 photos of the central region, since fat accumulation initially occur in zone 3 (perivenular) of hepatocytes and, with the progression of steatosis, it reaches zones 2 and 1 (periportal) [1,2,[11][12][13]. In each photo, 10 nuclei and 10 cytoplasm tissues were analyzed.…”

Section: Histopathological Examination Of the Livermentioning

confidence: 99%

“…Alcohol abstinence is associated with histological normalization in 27% of patients with alcoholic hepatitis, with progression to cirrhosis in 18% and persistent hepatitis in the others [9,10]. Although considered a benign and reversible histological abnormality, patients with steatosis that persist consuming alcohol may develop fibrosis and in some cases, cirrhosis, without prior development of steatohepatitis [11].…”

Section: Introductionmentioning

confidence: 99%

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Liver Histology after Chronic Use of Alcohol and Exercise Training in Rats

Lucca¹,

Pereira²,

Righi³

et al. 2018

JPP

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Abstract:Objectives: To investigate the effects of physical training on the liver morphology and morphometry after chronic use of alcohol in rats. Methods: Twenty-four Wistar rats were housed in cages with controlled environment and randomly divided into four groups according to treatment received. In the initial treatment, alcohol was administered to SA (sedentary alcohol) and EA (exercise alcohol) groups. After four weeks, physical training program was held on a treadmill with EA and EC (exercise control) groups. Area, perimeter, maximum and minimum diameter and form factor of nucleus and cytoplasm of hepatocytes were analyzed. Key findings: Micro-vesicular fatty degeneration, predominantly pericentrolobular, of mild to moderate intensity, was found especially in animals treated with alcohol. EC group showed nucleus area greater than the nucleus area of EA and SA groups. The form factor was lower in the EC group than in the EA group. EA group showed maximum cytoplasm diameter is smaller than in SC (sedentary control) group. Conclusions: Physical training for two weeks was not enough to suppress histopathologic changes in the liver caused by chronic use of alcohol in rats. Chronic use of alcohol seems to have minimized the beneficial effect of physical training in the nucleus area of hepatocytes.

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Section: Histopathological Examination Of the Livermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Liver Histology after Chronic Use of Alcohol and Exercise Training in Rats

Lucca¹,

Pereira²,

Righi³

et al. 2018

JPP

View full text Add to dashboard Cite

show abstract

“…The metabolic syndrome alone is another possible consequence of heavy alcohol consumption even though the mechanism of onset of the syndrome remains unclear 139,140 . The association between liver diseases and alcoholism is also known 141 and in alcohol liver diseases the activation of ethanol to acetaldehyde and alcohol induced fibrosis and inflammation takes place resulting in hepatitis manifestation after a period of heavy drinking [142][143][144] .…”

Section: Alcoholism and Consequent Disordersmentioning

confidence: 99%

Toxicology and the biological role of methanol and ethanol: Current view

Pohanka¹

2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Alcohol variants such as ethanol and methanol are simple organic compounds widely used in foods, pharmaceuticals, chemical synthesis, etc. Both are becoming an emerging health problem; abuse of ethanol containing beverages can lead to disparate health problems and methanol is highly toxic and unfit for consumption. Methods and Results. This review summarizes the basic knowledge about ethanol and methanol toxicity, the effect mechanism on the body, the current care of poisoned individuals and the implication of alcohols in the development of diseases. Alcohol related dementia, stroke, metabolic syndrome and hepatitis are discussed as well. Besides ethanol, methanol toxicity and its biodegradation pathways are addressed. Conclusions. The impact of ethanol and methanol on the body is shown as case reports, along with a discussion on the possible implication of alcohol in Alzheimer's disease and antidotal therapy for methanol poisoning. The role of ethanol in cancer and degenerative disorders seems to be underestimated given the current knowledge. Treatment in case of poisoning is another issue that remains unresolved even though effective protocols and drugs exist.

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“…The natural history of liver disease is well documented and encompasses a spectrum of disease states including earlier stages of fatty liver disease such as steatosis, steatohepatitis, and later stages of disease including fibrosis and cirrhosis (30,31). The earliest stage of liver disease, simple steatosis, is characterized by micro-and macro-vesicular fat accumulation and is generally considered reversible if appropriate changes to the lifestyle are made and maintained.…”

Section: Natural History Of Liver Diseasementioning

confidence: 99%

“…In the absence of lifestyle modifications, individuals may develop steatohepatitis, which is characterized by persistence of accumulated fat in addition to chronic hepatic inflammation (hepatitis). Later stages of liver disease, including fibrosis and cirrhosis, are characterized by collagen deposition and regenerative nodules, respectively (31,32).…”

Section: Natural History Of Liver Diseasementioning

confidence: 99%

Extracellular matrix proteins and the liver-lung axis in disease.

Massey

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Prevalence and Natural History of Alcoholic Liver Disease

Cited by 123 publications

References 27 publications

Liver Histology after Chronic Use of Alcohol and Exercise Training in Rats

Liver Histology after Chronic Use of Alcohol and Exercise Training in Rats

Toxicology and the biological role of methanol and ethanol: Current view

Extracellular matrix proteins and the liver-lung axis in disease.

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