“…Rare published studies originating from the LAC region indicate highly variable prevalence rates between countries such as Brazil, Ecuador and Peru, with differing methodologies between studies in terms of information sources, data exhaustiveness, case and outcome definitions, study population selection criteria, as well as the absence of reliable data pertaining to infants under 1 year or complex CHD subtypes. 13 , 14 , 29 , 30 , 31 , 32 , 33 To date, the main regional reference for the LAC region and the rest of South America remains the CHD prevalence projections at birth from the Global Burden of Disease (GBD) study with estimates for prevalence and mortality for overall CHD and different CHD sub-types in infants under 1 year available only in the GBD 1990–2017 study. 12 , 13 As with EPICARD, due to divergent eligibility criteria for CHD cases, overall live birth CHD prevalence and related infant mortality could not be directly compared between GBD and French Guiana.…”