Prevalence and Outcomes of Mitral Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement: Findings From the Society of Thoracic Surgeons/American College of Cardiology (Sts/Acc) Transcatheter Valve Therapies (Tvt) Registry

Joseph, Lee; Bashir, Mohammad; Xiang, Qun; Yerokun, Babatunde A.; Matsouaka, Roland; Vemulapalli, Sreekanth; Kapadia, Samir; Zahr, Firas

doi:10.1016/s0735-1097(17)34610-7

Cited by 14 publications

(27 citation statements)

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“…The recently published work by Jospeh et al 6 has demonstrated a higher in-hospital mortality in patients with severe MS who underwent TAVR, which supports our findings. In addition, the 1year mortality and the composite outcome of mortality, stroke, heart failure-related hospitalization and re-intervention of mitral disease were higher in both severe MS and nonsevere MS patients who underwent TAVR.…”

Section: Discussionsupporting

confidence: 92%

“…The coexistence of mitral stenosis (MS) and aortic stenosis (AS) is far from being exceptional in SAVR. Current registries suggest a prevalence of 11.6% of mitral stenosis in patients undergoing TAVR 6 . In one study, 17% of patients referred for aortic valve replacement were found to have mitral stenosis 7 with double valve surgery associated with higher operative mortality and lower long-term survival rates compared with those undergoing isolated aortic valve replacement 7,8 .…”

Section: Introductionmentioning

confidence: 99%

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In-Hospital Outcomes of Transcatheter Aortic Valve Implantation in Patients With Mitral Valve Stenosis

Al‐Khadra

Alraies

Darmoch

et al. 2019

The American Journal of Cardiology

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Background: Little is known about the outcome of patients with MS undergoing transcatheter aortic valve replacement (TAVR). Therefore, we sought to evaluate the potential impact of MS on the outcome of patients who underwent TAVR using the US national cohort. Method: Using weighted data from the National Inpatient Sample (NIS) database between 2011 and 2015, we identified patients who had undergone a TAVR as a primary procedure. Patients with MS diagnosis were compared to those without MS. Univariate and multivariate logistic regression analysis were performed for the outcomes of in-hospital mortality and post-procedural complications. Outcomes were also stratified by the type to TAVR (endovascular versus transapical). Results: A total of 62,110 patients underwent TAVR (mean age 81 ± 8.72, 47.4% females, and 3.7% African Americans) and 887 patients had MS (1.43%). Patients with concomitant MS had higher in-hospital mortality (5.1% vs 3.5% adjusted Odds Ratio [aOR], 1.455; 95% confidence interval [CI], 1.059-2.001, P=0.021), major adverse cardiac events (MACE) (9.0% vs 7.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

In-Hospital Outcomes of Transcatheter Aortic Valve Implantation in Patients With Mitral Valve Stenosis

Al‐Khadra

Alraies

Darmoch

et al. 2019

The American Journal of Cardiology

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“…This is in agreement with findings from the multicenter German TAVI registry, which also found calcification to be unrelated to the frequency of death, stroke, and MI at 30 days . Also consistent with the literature are the higher frequencies of clinically relevant mitral regurgitation, mitral stenosis, and PVL in patients experiencing poorer outcomes post‐TAVI, supporting the validity and pertinence of our data.…”

Section: Discussionsupporting

confidence: 92%

Degree of valve calcification in patients undergoing transfemoral transcatheter aortic valve implantation with and without balloon aortic valvuloplasty: Findings from the multicenter EASE‐IT TF registry

Butter

Okamoto

Schymik

et al. 2019

Cathet Cardio Intervent

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Aims We aimed to assess whether the level of aortic root calcification is associated with BAV performance/omission during transcatheter aortic valve implantation (TAVI), and to explore related outcomes. Methods and results EASE‐IT TF was a prospective, observational, multicenter registry of patients undergoing TF‐TAVI with the Edwards SAPIEN 3, with or without BAV predilation. Valvular calcification was quantified from pre‐procedural multi‐slice computed tomography images and compared between BAV and no BAV patients. Data for 178 patients (55 BAV; 123 no BAV) were analyzed. There were no significant differences between groups in terms of regional/leaflet sector calcification volumes, maximum asymmetry between the different leaflet sectors, or total calcification scores. Overall, a greater‐than‐average leaflet calcification volume was independently predictive of ≥mild PVL (OR: 5.116; 95% CI: 1.042–38.35) and the need for post‐dilation (OR: 3.592; 95% CI: 1.173–12.14). The latter effect was abated in patients with BAV (OR: 1.837; 95% CI: 0.223–18.00) and intensified in those without BAV (OR: 5.575; 95% CI: 1.114–38.74). No other BAV‐dependent effects of calcification on outcomes were observed. Conclusions In the majority of transfemoral valve implantations, calcification does not appear to be the main driving factor in the decision to perform/omit BAV. Predilation may be valuable for reducing post‐dilation requirements in patients only with a greater degree of leaflet calcification.

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“…Mitral stenosis (MS) affects 11% of patients undergoing transcatheter aortic valve replacement (TAVR) and is a predictor of in‐hospital and long‐term mortality when MS is severe . Simultaneous aortic and mitral valve replacement (TMVR) is feasible in patients with native mitral valve stenosis .…”

Section: Introductionmentioning

confidence: 99%

“…Mitral stenosis (MS) affects 11% of patients undergoing transcatheter aortic valve replacement (TAVR) and is a predictor of in-hospital and long-term mortality when MS is severe. 1 Simultaneous aortic and mitral valve replacement (TMVR) is feasible in patients with native mitral valve stenosis. 2 However, in patients with an Alfieri Stitch the TMVR procedure may be difficult due to the double orifice configuration of the mitral valve, which may lead to valve malposition, stent under expansion and/or severe paravalvular regurgitation.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous transfemoral transcatheter aortic valve replacement and trans‐septal mitral valve‐in‐ring implantation after partial laceration of an Alfieri stitch

Garcia

Mbai

Kelly

et al. 2018

Cathet Cardio Intervent

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Prevalence and Outcomes of Mitral Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement: Findings From the Society of Thoracic Surgeons/American College of Cardiology (Sts/Acc) Transcatheter Valve Therapies (Tvt) Registry

Cited by 14 publications

References 0 publications

In-Hospital Outcomes of Transcatheter Aortic Valve Implantation in Patients With Mitral Valve Stenosis

In-Hospital Outcomes of Transcatheter Aortic Valve Implantation in Patients With Mitral Valve Stenosis

Degree of valve calcification in patients undergoing transfemoral transcatheter aortic valve implantation with and without balloon aortic valvuloplasty: Findings from the multicenter EASE‐IT TF registry

Simultaneous transfemoral transcatheter aortic valve replacement and trans‐septal mitral valve‐in‐ring implantation after partial laceration of an Alfieri stitch

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