Prevalence and Outcomes of Pericardial Effusion in Kidney Transplant Candidates

Ashraf, Hasan; Hong, Liu; Tran, Khang H.; Agasthi, Pradyumna; Keddis, Mira T.; Unzek, Samuel; Narayanasamy, Hemalatha; Wilansky, Susan

doi:10.1016/j.amjcard.2020.07.009

Cited by 5 publications

(6 citation statements)

References 12 publications

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“…Pericardial effusion may occur after acute myocardial infarction. In a previous cohort study, pericardial effusion was found in 28% of patients with acute myocardial infarction [7]. In this study, we found that 11% of patients had a history of myocardial infarction.…”

Section: Discussionsupporting

confidence: 58%

Pericardial effusion and its relationship to age, sex, causes and degrees

Alsabbagh,

Tenawi,

Shamieh

2023

Preprint

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Introduction Pericardial effusion is one of the most important and dangerous cardiac manifestations that may lead to death. This study aims to study the characteristics of pericardial effusion in patients attending Damascus Hospital and its relationship to age and gender. Determination of demographic factors associated with pericardial effusion in patients. Methods A retrospective study was conducted during the years 2013–2023. The inclusion criteria were all patients with pericardial effusion who were admitted to the cardiovascular department of Damascus Hospital. Chi-square analysis was used to compare infarct type and age groups with sociodemographic factors and patients' medical history variables. Results Out of 100 cases of pericardial effusion in the internal cardiac department in Damascus Hospital, 41% of patients were younger than 40 years, compared to 59% who were older than 40 years. Of these, 57% were males, compared to 43% were females. High arterial tension was a prominent history of pericardial effusion in 51% of patients, 12% suffered from heart failure, 19% from diabetes, 20% from kidney failure, and 11% from myocardial infarction. 20% of patients had a mild effusion, 40% a moderate effusion, 43% a heavy effusion, and 10% a pericardial tamponade. Death occurred in only 10% of patients with pericardial effusion, compared to 90% of patients who recovered. Most patients with pericardial effusion had a significant relationship with demographic factors (age, gender), medical history and death. Conclusion The results of this study indicate the presence of a combination of risk factors in older adults with pericardial effusion. Programs targeting sociodemographic factors, including smoking, obesity, and comorbidities, are necessary to more effectively address health disparities in pericardial effusion and its negative consequences.

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Section: Discussionsupporting

confidence: 58%

Pericardial effusion and its relationship to age, sex, causes and degrees

Alsabbagh,

Tenawi,

Shamieh

2023

Preprint

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“…The findings suggested that the duration of hemodialysis was a key protective factor against developing moderate to large PE. Patients in this study were followed for an average of 39 months, revealing a 10-year survival rate of 87%, indicating a favorable prognosis [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although the risk of drainage in PE is influenced by its severity, directly comparing our results with their study is challenging due to differences in population groups, methodologies, and data reporting. Additionally, some studies report no significant relationship between serum albumin and PE in mixed populations of dialysis and non-dialysis CKD patients [ 31 , 35 ], further illustrating the variability in findings across different research contexts.…”

Section: Discussionmentioning

confidence: 99%

Pericardial effusion in patients with chronic kidney disease: A two-center study

Eslami,

Mousavi,

Irilouzadian

et al. 2024

PLoS ONE

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Background and aims Pericardial effusion (PE) is a prevalent form of pericardial involvement in chronic kidney disease (CKD). This study aims to investigate the clinical and laboratory features associated with PE severity in patients with CKD. Methods In this cross-sectional study, we examined the medical records of patients admitted to tertiary hospitals with International Classification of Diseases 10th Revision (ICD-10) codes associated with CKD and PE. We included 112 CKD patients in stage 4 and 5 non-dialysis (ND) with PE for assessing the clinical and laboratory features of severity. Results Patients were divided into two categories based on the severity of PE. Seventy-two patients had mild and 40 had moderate and severe PE. Univariate analysis of demographic and laboratory features on the date of admission demonstrated that chest pain, dyspnea, serum albumin, and neutrophil-to-lymphocyte ratio (NLR) are associated with the severity of PE. The univariate analysis on the date of echocardiography showed significantly higher white blood cell count (WBC), neutrophil count (percentage and absolute count), and NLR, along with significantly lower lymphocyte percentage and serum albumin among patients with moderate and severe PE. In the multivariable analysis of laboratory features, on admission hypoalbuminemia (p-value = 0.014, OR = 4.03, CI: 1.32–12.25) and NLR greater than 5.5 (p-value = 0.015, OR = 4.22, CI: 1.32–13.50) were significantly associated with moderate and severe PE. In a parallel matter, at the time of echocardiography hypoalbuminemia (p-value = 0.004, OR = 5.38, CI: 1.74–16.65) and neutrophilia (p-value = 0.005, OR = 7.94, CI: 1.89–33.44) were significantly associated with moderate and severe PE. Conclusion Despite advancements in the diagnosis and treatment of CKD, PE is still a concerning issue in these patients. This study revealed that hypoalbuminemia, neutrophilia, and NLR greater than 5.5 could be predictive factors of moderate and severe PE in CKD patients with PE. Further prospective study with larger sample size is needed to confirm these results.

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“…[ 26 ] Uremic pericarditis, pericardial effusion and chronic left heart failure were common clinical manifestations in patients with end stage renal disease. [ 27 ] It was suggested that accumulation of toxic metabolites may play an important role in cardiovascular damage in end stage renal disease patients. [ 28 ] These studies showed that there were close relationships between cardiovascular involvement and renal involvement in AAV patients.…”

Section: Discussionmentioning

confidence: 99%

“…The tryptophan may also cause atherosclerosis through the release of reactive oxygen species that cause endothelial damage [26] . Uremic pericarditis, pericardial effusion and chronic left heart failure were common clinical manifestations in patients with end stage renal disease [27] . It was suggested that accumulation of toxic metabolites may play an important role in cardiovascular damage in end stage renal disease patients [28] .…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of HEp-2 cell cytoplasmic patterns in anti-neutrophil cytoplasmic antibody associated vasculitis

Zhang

Bao

et al. 2022

Medicine

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The study was to investigate the clinical characteristics and significance of antinuclear antibody (ANA) cytoplasmic patterns in ANCA-associated vasculitis (AAV) from Southwest China. A retrospective study including 232 AAV patients from Peoples Hospital of Deyang City was performed. These included 115 patients with ANA cytoplasmic pattern as observation group and 117 patients without ANA cytoplasmic pattern as control group. Chest involvement (60.00 vs 46.15, P = .035), cardiovascular involvement (5.21 vs 29.91, P < .001), and renal involvement (37.39 vs 77.78, P = .001) were different between groups. Total protein (69.55 vs 64.01, P < .001), triglyceride (1.41 vs 1.18, P = .023), mean cell volume (89.76 vs 87.59, P = .040), and estimated glomerular filtration rate (76.67 vs 50.87, P = .035) were higher in ANA cytoplasmic patterns group. Creatinine (73.00 vs 117.50, P = .011), white blood cell (6.93 vs 8.86, P = .001), platelet (196.0 vs 239.0, P = .017), anti-myeloperoxidase (2.44 vs 3.42, P = .042), and anti-proteinase 3 (1.00 vs 4.93, P = .007) were lower in this group. In multivariate analysis, creatinine (odds ratio [OR] = 1.21, 95% confidence interval [CI]: 1.06–1.38), triglyceride (OR = 1.97, 95% CI: 1.10–3.48), and anti-myeloperoxidase (OR = 1.64, 95% CI: 1.37–1.95) were independent risk factors of AAV renal involvement. Total protein (OR = .95, 95% CI: 0.91–0.99) was an independent protective factor of AAV renal involvement. Chi-square test showed that speckled pattern was different among anti-neutrophil cytoplasmic antibody patterns ( χ 2 = 18.526, P < .001). In summary, HEp-2 cell cytoplasmic patterns have certain clinical significance in AAV, which is a new exploration of the clinical value of ANA.

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Prevalence and Outcomes of Pericardial Effusion in Kidney Transplant Candidates

Cited by 5 publications

References 12 publications

Pericardial effusion and its relationship to age, sex, causes and degrees

Pericardial effusion and its relationship to age, sex, causes and degrees

Pericardial effusion in patients with chronic kidney disease: A two-center study

Clinical significance of HEp-2 cell cytoplasmic patterns in anti-neutrophil cytoplasmic antibody associated vasculitis

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