Prevalence and Pharmacological Factors Associated With Impulse-Control Disorder Symptoms in Patients With Parkinson Disease

Pérez-Lloret, Santiago; Rey, María Verónica; Fabre, Nelly; Ory, Fabienne; Spampinato, Umberto; Brefel‐Courbon, Christine; Montastruc, Jean‐Louis; Rascol, Olivier

doi:10.1097/wnf.0b013e31826e6e6d

Cited by 91 publications

(86 citation statements)

References 20 publications

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“…Although ICDs are commonly under reported (Vilas, Pont-Sunyer, & Tolosa, 2011), it is estimated that between 10 and 14% of people with PD have ICDs (Giladi et al, 2007;Poletti et al, 2013;Weintraub, Potenza, Siderowf, & Voon, 2010), compared to between 1 and 8% within the general population (Dell'Osso, Altamura, Allen, Marazziti, & Hollander, 2006). Where explicit comparisons have been made between people with PD and matched controls, ICDs are around twice as common in Parkinson's patients than in controls (Rodriguez-Violante, Gonzalez-Latapi, Cervantes-Arriaga, Camacho-Ordonez, & Weintraub, 2015), although the difference can be even greater (Perez-Lloret, Rey, Fabre, Ory, Spampinato, Brefel-Courbon, Montastruc, & Rascol, 2012).…”

Section: Introductionmentioning

confidence: 99%

Impulse control disorders in Parkinson’s disease: Predominant role of psychological determinants

Garlovsky

Simpson

Grünewald

et al. 2016

Psychology & Health

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Objectives: Impulse Control Disorders (ICDs) in Parkinson's disease (PD) have previously almost exclusively been considered to result from anti-parkinsonian medication. However, this biomedical perspective has failed to achieve a full understanding of the phenomenon and it is argued that a failure to consider psychological factors is a critical omission. Design: The present study examined the predictive relationship between ICDs in PD and a range of

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Section: Introductionmentioning

confidence: 99%

Impulse control disorders in Parkinson’s disease: Predominant role of psychological determinants

Garlovsky

Simpson

Grünewald

et al. 2016

Psychology & Health

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“…Moreover, approximately 30% of patients with long-standing PD develop depression, which is partially attributable to the disease itself. Dementia in PD patients is related to the age of PD onset, rather than to the duration of the disease (6,9,14,16). Psychiatric symptoms -such as compulsive behavior, gambling etc.…”

Section: Introductionmentioning

confidence: 99%

Unilateral subthalamic nucleus stimulation in the treatment of asymmetric parkinson's disease with early motor complications.

Sobstyl¹,

Ząbek²,

Zaczyński³

et al. 2015

Turkish Neurosurgery

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Patients with advanced PD and older age at surgery may not easily tolerate bilateral STN DBS, unlike younger patients with moderate PD. Moreover, approximately 30% of patients with long-standing PD develop depression, which is partially attributable to the disease itself. Dementia in PD patients is related to the age of PD onset, rather than to the duration of the disease (6,9,14,16). Psychiatric symptoms -such as compulsive behavior, gambling etc. -may be triggered or aggravated by long-term medication, especially in dopamine agonist therapy (14,27). Moreover, in the course of the disease a number of █ InTRODuCTIOn P arkinson's disease (PD) is diagnosed clinically based on the cardinal motor symptoms including resting tremor, rigidity and bradykinesia. A characteristic feature of early idiopathic PD is asymmetric motor symptom onset. In advanced PD, it is sometimes difficult to recognize which side of the body was first affected by disease. Generally, patients with advanced PD, with severe bilateral levodopa-induced dyskinesia (LID) and motor fluctuations require bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) (17,21). AIM:The aim of this study was to assess the results of unilateral subthalamic nucleus (STN) stimulation for the treatment of Parkinson's disease (PD) with marked asymmetry of parkinsonian motor symptoms and early motor complications. MATERIAL and METhODS:The clinical series consisted of 32 consecutive PD patients, in whom unilateral STN stimulation was performed. All patients were assessed according to the Unified Parkinson's Disease Rating Scale (UPDRS), and Hoehn and Yahr staging. The patients were assessed preoperatively, and at 12, and 24 months after unilateral STN stimulation. 22 patients were followed for 2 years. RESuLTS:Medication off/stimulation on total UPDRS motor scores were improved by 29% when compared to the baseline medication off motor scores. The contralateral motor scores improved by 49%, whereas the axial motor scores by 18% in medication off/stimulation on condition. The duration and severity of levodopa induced dyskinesia were reduced respectively by 73% and by 77%. The daily levodopa dose was decreased by only 10%.COnCLuSIOn: Unilateral STN stimulation is a safe and effective procedure for selected patients with marked asymmetry Parkinson's disease motor symptoms and early motor complications.

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“…A work by Pérez-Lloret and collaborators evaluated the incidence of impulse monitoring diseases and pharmacological variables associated with a group of sufferers with (n = 203) and without pd (n = 52, poststroke patients) in a sample of French patients (Pérez-Lloret et al, 2012). The disorders related to impulse control explored in the study were: gambling disorder, uncontrollable sexual behavior, compulsive shopping and uncontrollable eating.…”

Section: Overview Of the Experimental Work About The Relationship Betmentioning

confidence: 99%

“…For instance, treatment with dopaminergic drugs like Pramipexole -a partial/full D2/D3/D4 receptor agonist (Riba et al, 2008), Piribedil -a D2/D3 receptor agonist and D4 receptor antagonist (Micheli et al, 2015), Aripiprazole -a D2/D3/D4 receptor partial agonist (Gaboriau et al, 2014), and higher dosages of anti-Parkinsonian drugs (levodopa, dopamine equivalents or levodopa equivalents; Pontieri et al, 2015) have shown relatedness to gambling disorder in pd patients. On the other hand, dopamine related treatments like high dosages of anti-Parkinsonian drugs (levodopa, dopamine equivalents, levodopa equivalents; Pontieri et al, 2015), levodopa or dopamine agonists (Weintraub et al, 2010), type B monoamine oxidase inhibitors (Pérez-Lloret et al, 2012), increase the incidence of other impulse control disorders in pd patients based on different studies. On the other hand, deep brain stimulation (sub-thalamic nucleus) in advanced stage pd patients alters the judgment during "chasing losses" (Rogers et al, 2011).…”

Section: Conclusion Of the Experimental Work About The Association Bmentioning

confidence: 99%

“…3) Other factors that could increase the probability of gambling disorder in pd patients are: novelty seeking, personal or family background of alcohol abuse disorder (Voon et al, 2007), younger age at pd beginning (Siri et al, 2010;Voon et al, 2007), male gender (Siri et al, 2010), longer term of disease, more severe psychotic symptoms, more severe anxiety, more severe depression (Pontieri et al, 2015), older age, later onset of gambling disorder, and augmented bingo playing (Jiménez-Murcia et al, 2012). 4) On the other hand, possible variables that could increase the incidence of other impulse control disorders (for instance: hypersexuality, compulsive eating or compulsive shopping) in pd patients are: younger age of pd disease onset (Pérez-Lloret et al, 2012;Weintraub, 2009;Weintraub et al, 2010), male gender (Weintraub, 2009), unmarried (Weintraub et al, 2010), longer pd duration (Pontieri et al, 2015), mental disorder-related factors like disorder's severity (psychotic, anxiety or depression; Pontieri et al, 2015), impulsiveness, personal history of a disorder (substance abuse, bipolarity or impulse control; Weintraub, 2009), and current cigarette smoking (Weintraub et al, 2010). Finally, the presence of family background of a disorder -substance abuse, bipolarity (Weintraub, 2009), or gambling disorder (Weintraub et al, 2010)-could also increase the probability of an impulse control disorder in a pd patient.…”

Section: Conclusion Of the Experimental Work About The Association Bmentioning

confidence: 99%

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A Revision of the Relationship between Gambling Disorder, Attention Deficit Hyperactivity Disorder and Parkinson´s Disease

Quintero-Garzola¹

2017

Pensando Psicol.

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Purpose: For the present review, publications in the field of gambling disorder that deal with its relationships with others, mainly attention deficit hyperactivity disorder (adhd) and Parkinson's disease (pd) were consulted. Methods: The current revision includes a total of 63 references published between 1987 and 2017. It included human studies and revisions regarding the comorbidity of gambling disorder with adhd or pd. The search terms included: gambling disorder, gambling disorder comorbidity, gambling disorder and adhd, gambling disorder and pd, gambling disorder and impulsivity. The present review focused on the link among gambling disorder and adhd or pd, because there were a large number of publications related to these disorders. For organization purpose the current work was split into two main parts: 1) Revision of previous scientific reviews about gambling disorder, and 2) Overview and conclusions of experimental work about gambling disorder. Conclusions: The principal conclusions of the current review are: 1) subjects with a gambling disorder have a higher incidence of adhd (and also of attention deficit disorder [add]), 2) the presence of adhd in subjects that suffer of gambling disorder implies more challenges for the health care system, and 3) pd treatments that increase the agonism of dopamine type of receptor are related to an elevated probability for developing a gambling problem or an impulse control disorder.Keywords: adhd, comorbidity, disorder, dopamine receptor, gambling pd. ResumenObjetivo: para la presente revisión, se consultaron publicaciones en el campo de la ludopatía que tratan de sus relaciones con otros trastornos, principalmente el trastorno por déficit de atención con hiperactividad (tdah) y la enfermedad de Parkinson (ep). Método: la presente revisión tiene en cuenta 63 referencias publicadas entre 1987 y 2017 y tuvo en cuenta estudios en humanos y revisiones sobre la comorbilidad de la ludopatía con el tdah o la ep. Los términos de la búsqueda incluyeron: ludopatía, comorbilidad de la ludopatía, ludopatía y tdah, ludopatía y ep, ludopatía e impulsividad. Esta revisión se centró en el vínculo entre la ludopatía y el tdah o la ep, puesto que existía un gran número de publicaciones relacionadas con estos trastornos. Para su organización, el presente trabajo se dividió en dos partes principales: 1) el análisis de revisiones científicas anteriores sobre la ludopatía y 2) el resumen y las conclusiones del trabajo experimental sobre la ludopatía. Conclusiones: las conclusiones principales de esta revisión son: 1) los sujetos con ludopatía tienen una mayor incidencia del tdah (y también del trastorno de déficit de atención [tda]), 2) la presencia del tdah en sujetos que sufren de ludopatía implica más retos para el sistema de salud y 3) los tratamientos de la ep que aumentan el agonismo del receptor tipo dopamina están relacionados con una probabilidad elevada de desarrollar un problema de juego o un trastorno de control de impulsos.Palabras clave: tdah, comorbilidad, trasto...

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Prevalence and Pharmacological Factors Associated With Impulse-Control Disorder Symptoms in Patients With Parkinson Disease

Cited by 91 publications

References 20 publications

Impulse control disorders in Parkinson’s disease: Predominant role of psychological determinants

Impulse control disorders in Parkinson’s disease: Predominant role of psychological determinants

Unilateral subthalamic nucleus stimulation in the treatment of asymmetric parkinson's disease with early motor complications.

A Revision of the Relationship between Gambling Disorder, Attention Deficit Hyperactivity Disorder and Parkinson´s Disease

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