Prevalence and Predictive Factors of Harboring Fluoroquinolone-resistant and Extended-spectrum β-Lactamase–producing Rectal Flora in Hong Kong Chinese Men Undergoing Transrectal Ultrasound-guided Prostate Biopsy

Prevalence of fluoroquinolone‐resistant rectal flora in patients undergoing transrectal ultrasound‐guided prostate needle biopsy: A prospective multicenter study

“…According to a study carried out in Thailand, 92.3% patients undergoing TRUSBx reportedly showed FQ resistance in fecal flora . Among Hong Kong Chinese men, a total of 199 of 371 patients (53.6%) carried antibiotic‐resistant rectal flora, with 40.4 and 41.0% of patients having FQ‐R and ESBL‐producing bacteria, respectively . Similar to the present study, the high prevalence of FQ‐R bacteria and the current choice of FQ as a prophylactic antibiotic did not lead to high postbiopsy infection; however, the reason is currently inconclusive.…”

“…11 Among Hong Kong Chinese men, a total of 199 of 371 patients (53.6%) carried antibioticresistant rectal flora, with 40.4 and 41.0% of patients having FQ-R and ESBL-producing bacteria, respectively. 9 Similar to the present study, the high prevalence of FQ-R bacteria and the current choice of FQ as a prophylactic antibiotic did not lead to high postbiopsy infection; however, the reason is currently inconclusive. The pharmacokinetics of FQ might influence this result with the route, dosage and timing of antibiotic administration, but the reason is currently inconclusive.…”

“…Similar to the present study, the high prevalence of FQ‐R bacteria and the current choice of FQ as a prophylactic antibiotic did not lead to high postbiopsy infection; however, the reason is currently inconclusive. The pharmacokinetics of FQ might influence this result with the route, dosage and timing of antibiotic administration, but the reason is currently inconclusive . In our case, the results between rectal flora and lower infectious complication rate might be explained by povidone‐iodine rectal cleansing and the duration of antibiotic prophylaxis.…”

Antibiotic susceptibility of intestinal Escherichia coli in men undergoing transrectal prostate biopsies: a prospective, registered, multicentre study

“…Previously, it has been reported that FQ‐R coliforms can be found in 10.6–40.4% and ESBL‐producing organisms in 1.3–41.0% of pre‐TRUS‐Bx rectal swab cultures . In these studies, E. coli was the most common FQ‐R and ESBL‐producing gram‐negative organism.…”

“…In pre‐TRUS‐Bx rectal swab samples, Taylor et al were unable to detect differences in FQ‐R rates with age or diabetes. Tsu et al detected a statistically significant increase in E. coli antimicrobial resistance with diabetes but no correlation with age. Duplessis et al detected an increase in the FQ‐R rate with age.…”