Prevalence and predictors of atlanto-axial subluxation in rheumatoid arthritis after 12-years’ follow-up (ESPOIR Cohort)

Abstract

Objectives Anterior atlanto-axial subluxation (AAS), defined as an anterior atlanto-dental interval (aADI) ≥3 mm, can occur in rheumatoid arthritis (RA) and carries a risk of severe neurological impairments. Our objective was to determine the prevalence and predictors of radiographic aAAS after 12 years’ follow-up of patients with early polyarthritis. Methods We studied patients enrolled in the early-polyarthritis cohort ESPOIR between 2002 and 2005 (at least two swollen joints for >6 weeks and <6 months, no other diagnosis than RA, and no previous exposure to glucocorticoids or disease-modifying anti-rheumatic drugs). All patients still in the cohort after 12 years had dynamic cervical-spine radiographs taken then read by two blinded observers. To evaluate how well combinations of tests performed at baseline and 10 years predicted aAAS after 12 years, univariate analysis and multiple logistic regression procedure were applied. Results Of 323 patients followed for 12 years, 15 (4.6%; 95% confidence interval: 2.8–6.4) had aAAS. Among baseline variables, only IgA rheumatoid factors were associated (p< 0.05) to aAAS (sensitivity 60%, specificity 75%). Among data collected after 10 years, oral corticosteroid therapy during the 10-year interval, treatment by DMARDs, CRP (mg/dl), and positive tests for RFs were associated with aAAS after 12 years, but only CRP and RFs remained in a model of logistic regression (combination predicted aAAS with a sensitivity of 60% for a specificity of 90%). Conclusion In conclusion, the prevalence of aAAS after 12 years was 4.6% in the ESPOIR cohort, with no patients having severe aAAS. Although some factors were found statistically associated to AAS, the event is too rare to allow a clinical relevance.

Prevalence of anterior atlantoaxial subluxation and association with established rheumatoid arthritis

“…In a study from the ESPOIR cohort, the prevalence of aAAS after 12 years was 4.6%, with no patients with severe aAAS. However, in these studies, CRP and RF were statistically associated with AAS (Le Quellec et al., 2023).…”

Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review

“…The duration of the disease varied, with some individuals having RA for 2 years, 5 years, or even more than 10 years. A disease duration of more than 10 years was identified as a significant predictor of cervical spine damage [ 13 ]. Nevertheless, it is important to note that atlantoaxial subluxation can occur at any age, and age alone is not a barrier to its development in rheumatoid arthritis.…”