Prevalence and predictors of hand involvement in Thai patients with systemic sclerosis

Wangkaew, Suparaporn; Sivasomboon, Chate; Leungwatthananon, Wit; Kasitanon, Nuntana; Louthrenoo, Worawit

doi:10.1111/1756-185x.12919

Cited by 10 publications

(16 citation statements)

References 26 publications

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“…16 On the contrary, limited studies from Asian countries reported variable results ranging from 9% in Thailand, 29% in Turkey, and 71% in China. 15,30,31 The statistically different prevalence of arthritis between the two nations of this study may come from the routine prescription of lowdose steroid for the SSc patients in Iran. This can probably justify the lower prevalence of pericardial effusion among Iranian patients than in French cases (3% vs 10.4%, p-value adj = 0.041).…”

Section: Discussionmentioning

confidence: 90%

Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers

Allanore

Gharibdoost

Jamshidi

et al. 2018

Journal of Scleroderma and Related Disorders

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Objectives: Systemic sclerosis is a severe and rare chronic auto-immune multisystem disorder characterized by vasculopathy and skin stiffness. Ethnic and geographical origin can influence the outcomes. In this study, we compared the phenotypic characteristics of Iranian and French patients. Methods: This cross-sectional study was performed on 200 Iranian and 268 French systemic sclerosis patients. Iranian patients collected from the Iranian systemic sclerosis cohort of the Rheumatology Research Center, Shariati hospital, Tehran University of Medical Sciences. The French population was monocentric, and it was constituted by the patients included locally in the EUSTAR database in December 2016. Results: The mean age at onset was significantly lower in Iranian patients (35.58 ± 11.68 vs 47.06 ± 13.54, p-value < 0.001). The female-to-male ratio was approximately 5.2:1 and was not different in the two populations. The prevalence of diffuse cutaneous systemic sclerosis was significantly higher in Iranian patients (60.2% vs 42.85%, p-value < 0.001). Calcinosis cutis and joint synovitis were more prevalent in French patients (p-value = 0.013, <0.001). The positivity of anti-topoisomerase antibody was higher in Iranian patients, whereas the anti-centromere antibody predominated in French cases (p-value < 0.001). Restrictive pattern of pulmonary function test was more common in Iranian patients (p-value < 0.001), while estimated pulmonary arterial pressure by echocardiography was higher in French patients (p-value < 0.001). Conclusion: It seems that systemic sclerosis occurred in younger ages among Iranian female with the predominance of diffuse cutaneous subtype. In addition, lung interstitial disease appeared to be more prevalent and severe in Iranians than French patients.

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Section: Discussionmentioning

confidence: 90%

Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers

Allanore

Gharibdoost

Jamshidi

et al. 2018

Journal of Scleroderma and Related Disorders

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“…Similarly, the EUSTAR registry has shown the significant association of TFR with joint contracture and digital ulcers (17). Moreover, the multivariate analysis reinforced the correlation of hand and finger mRSS with digital ulcer development in the Thai SSc registry (18). The association of the digital ulcers and delta FTP can be justified by the probable association of hand movement and blood circulation in the fingers.…”

Section: N Discussionmentioning

confidence: 76%

The clinical value of the delta finger to palm distance in systemic sclerosis

et al. 2020

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Systemic sclerosis (SSc) is a collagen-vascular disorder characterized by fibrosis and vasculopathy. Delta finger to palm distance (delta FTP) is an index measuring the distance between the tip of the third finger to the distal palmar crease in the flexed and extended position. The present study aimed to evaluate the clinical value of delta FTP and to assess the correlation of delta FTP with modified Rodnan skin score (mRSS) and forced vital capacity (FVC) over the 12-month follow-up. This prospective longitudinal study began with 50 participants who were followed for twelve months. Lowess smoothing and linear regression were applied to detect and assess the relationship between delta FTP and mRSS. p-values were adjusted by the Benjamini-Hochberg method (BHM) as a control for false discovery rate. Delta FTP was lower among patients with higher disease duration (p-valueadj: 0.008), diffuse cutaneous SSc (p-valueadj: 0.006), digital ulcers (p-valueadj: 0.003), telangiectasia (p-valueadj: 0.006) and dysphagia (p-valueadj: 0.036). The mRSS has a significant negative linear effect on the delta FTP at the baseline and the end of the follow-up (r: -0.31 and -0.40, respectively). Moreover, changes of mRSS and delta FTP showed a negative linear association over time (r: -0.22). These linear effects remained significant after regrouping the patients based on their SSc subtype. Delta FTP and FVC were not correlated either at the baseline or at the end. It seems that the delta FTP can be a valuable clinical index, supported by its correlated changes with mRSS and other SSc clinical manifestations over the one-year follow-up.

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“…While the frequency of some ndings such as foot subluxation in past studies were close and ranging from 13.1% (3) to 16% (5) ; there were ndings like hand joint space narrowing with controversial reported frequencies, ranging from 17.9% (6) to 75.3% (7) . Most reports on the prevalence of radiological involvements in SSc were on hand and from Western countries (Europe (3)(4)(5)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) , Canada (18) , United States (19,20) and Africa (21) with only four previous reports from Asia (6,(22)(23)(24) . Few studies evaluated radiologic changes in the feet and they were from Europe (3,5,25) , Africa (21) and only one old from Asia (26) .…”

Section: Introductionmentioning

confidence: 99%

Hands and feet radiologic involvements in systemic sclerosis

Badiee

Fatemi

Zahedpasha

et al. 2022

Preprint

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Aim Systemic sclerosis (SSc) is a rare autoimmune disorder characterized by vascular and fibrosing involvement of the skin and internal organs. In this study we determined the prevalence and characteristics of radiological hands and feet involvements in Iranian SSc patients identified disease–phenotype associations. Methods 43 SSc patients (41 women and 2 men), with a median age of 44.79 years (ranges 26 to 70 years) and a mean disease duration of 11.78 years (ranges 2 to 28 years) were studied in this cross-sectional study. Results 42 patients had radiological changes both in hands and feet. Only one patient had changes just in hand. The most frequent changes that we found in hand was Juxta-articular Osteoporosis (93%), Acro-osteolysis (58.2%), Joint Space Narrowing (55.8%). The prevalence of joint space narrowing or acro-osteolysis were higher in subjects with active skin involvement (modified Rodnan skin score (mRSS) > 14) (16/21 v 4/16 for patients with inactive skin involvement (mRSS < 14); p = 0.002). The most frequent changes that we found in foot were Juxta-articular Osteoporosis (93%), Acro-osteolysis (46.5%), Joint Space Narrowing (58.1%), subluxation (44.2%). The presence of anti-ccp antibody was detected in 4 (9.3%), while positive rheumatoid factor was found in 13 (30.2%) of SSc patients. Conclusion This study corroborates that an arthropathy is common in SSc patients. The introduction of the specific radiological involvements of SSc needs to be confirmed by further studies. in order to define the appropriate prognosis and treatment of patients.

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Prevalence and predictors of hand involvement in Thai patients with systemic sclerosis

Cited by 10 publications

References 26 publications

Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers

Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers

The clinical value of the delta finger to palm distance in systemic sclerosis

Hands and feet radiologic involvements in systemic sclerosis

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